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Gene Review

INP51  -  phosphoinositide 5-phosphatase INP51

Saccharomyces cerevisiae S288c

Synonyms: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51, SJL1, Synaptojanin-like protein 1, YIA2C, YIL002C
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High impact information on INP51


Biological context of INP51


Anatomical context of INP51

  • A fluorescent dye that detects endocytic and vacuolar membranes suggests that the vacuole is highly fragmented in inp51 inp52 double mutants [3].
  • Our observations indicate that Inp51p, Inp52p, and Inp53p have distinct functions and that substrates and/or products of inositol polyphosphate 5-phosphatases may have roles in vesicle trafficking, membrane structure, and/or cell wall formation [3].

Associations of INP51 with chemical compounds


Other interactions of INP51

  • Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae [3].
  • The interaction between TAX4/IRS4 and INP51 is analogous to the association of EPS15 with the 5-phosphatase synaptojanin 1 in mammalian cells, suggesting that EPS15 is an activator of synaptojanin 1 [1].


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