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Gene Review

STS1  -  Sts1p

Saccharomyces cerevisiae S288c

Synonyms: DBF8, Dumbbell former protein 8, SEC23 suppressor 1, SSM5, Tethering factor for nuclear proteasome STS1, ...
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High impact information on STS1

  • STS1 also interacted with the second suppressor, RPN11, a subunit of the 26S proteasome, in the two-hybrid system [1].
  • We found that Sts1p interacts directly with Srp1p in vitro and also in vivo, as judged by coimmunoprecipitation and two-hybrid analyses [1].
  • DBF8 maps to chromosome IX near the centromere, and it encodes a 36-kDa protein that is essential for viability at all temperatures [2].
  • Although they show no evidence of DNA damage, dbf8 mutants exhibit increased rates of chromosome loss and nondisjunction even at a permissive temperature [2].
  • A chromosomal deletion of STS1 leads to viable delta sts1 cells of both mating types, suggesting that STS1 is not essential for cell growth [3].

Biological context of STS1


Physical interactions of STS1

  • The present data suggest that Sts1p may play a role in the transport of Rna15p from the cytoplasm to the nucleus [5].

Other interactions of STS1

  • Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation [1].
  • These features suggest that Sts1p may play a catalytic or regulatory role in conjunction with the more abundant Sec23p [4].
  • Use of the two-hybrid system suggests that Sts1p does not interact directly with Rna15p, but may be active as a homodimer [5].

Analytical, diagnostic and therapeutic context of STS1


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