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ZDS2  -  Zds2p

Saccharomyces cerevisiae S288c

Synonyms: MCS1, Protein ZDS2, YM8339.10, YML109W
 
 
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High impact information on ZDS2

  • Deletion of ZDS2 produced no obvious phenotype, and deletion of ZDS1 produced no obvious phenotype other than a mild effect on cell shape [1].
  • ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae [1].
  • The ZDS2 gene was isolated as a multicopy suppressor of the temperature-sensitive growth defect caused by the sin4 null mutation [2].
  • However, a strain with both ZDS1 and ZDS2 disrupted is extremely slowly growing, has marked defects in bud morphology, and shows defects in completing S phase or entering mitosis [2].
  • In contrast, deletion of its paralog ZDS2 caused a decrease in rDNA silencing, a decrease in life span and an increase in Sir3p phosphorylation [3].
 

Biological context of ZDS2

  • Sequence from the yeast genome project identified a homolog, ZDS2, whose predicted product of 942 amino acids is 38% identical in sequence to Zds1p [1].
  • This gene shares sequence homology with the ZDS1 and ZDS2 genes from Saccharomyces cerevisiae, which appear to be involved in multiple cellular events [4].
  • These data indicate that short YACs can be stabilized by trans-acting factors and suggest that the proteins encoded by ZDS1 and ZDS2 alter short YAC stability by interacting with proteins that function at the telomere [5].
  • The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids [5].
  • Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression [2].
 

Anatomical context of ZDS2

 

Associations of ZDS2 with chemical compounds

  • Among these genes, PDE2 and ZDS2 were repeatedly identified as genes whose overexpression confers cellular resistance to cisplatin [6].

References

  1. ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Bi, E., Pringle, J.R. Mol. Cell. Biol. (1996) [Pubmed]
  2. Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression. Yu, Y., Jiang, Y.W., Wellinger, R.J., Carlson, K., Roberts, J.M., Stillman, D.J. Mol. Cell. Biol. (1996) [Pubmed]
  3. Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Roy, N., Runge, K.W. Curr. Biol. (2000) [Pubmed]
  4. zds1, a novel gene encoding an ortholog of Zds1 and Zds2, controls sexual differentiation, cell wall integrity and cell morphology in fission yeast. Yakura, M., Ozoe, F., Ishida, H., Nakagawa, T., Tanaka, K., Matsuda, H., Kawamukai, M. Genetics (2006) [Pubmed]
  5. The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids. Roy, N., Runge, K.W. Chromosoma (1999) [Pubmed]
  6. A genome-wide screening in Saccharomyces cerevisiae for genes that confer resistance to the anticancer agent cisplatin. Burger, H., Capello, A., Schenk, P.W., Stoter, G., Brouwer, J., Nooter, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
 
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