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Gene Review:

SOK2 - Sok2p

Saccharomyces cerevisiae S288c

Synonyms: Protein SOK2, YM9711.03C, YMR016C

Ward, M.P. et al., Shenhar, G. et al., Enjalbert, B. et al., Yeang, C.H. et al.

Yeang, Mak, McCuine, Workman, Jaakkola, Ideker,

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High impact information on SOK2

We show that Sok2 associates with Msn2 [1].
Relief of repression of Sok2 depends on both the N-terminal domain of Sok2 and Ime1 [1].
Previously it was reported that overexpression of Sok2 suppresses the growth defect resulting from a temperature-sensitive PKA; thus Sok2 has a positive role in mitosis [1].
We show that in the presence of glucose IREu functions as a negative element and that Sok2 mediates this repression activity [1].
Our results demonstrate that Sok2, a positive regulator of mitosis, and Efg1, a positive regulator of filamentation, function as negative regulators of meiosis [1].

Biological context of SOK2

Expression of the PKA catalytic subunit genes is unaltered by deletion or overexpression of SOK2 [2].
These results suggest SOK2 plays a general regulatory role in the PKA signal transduction pathway [2].
Thus, the product of SOK2 may act downstream of PKA to regulate the expression of genes important in growth and development [2].
A positive regulator of mitosis, Sok2, functions as a negative regulator of meiosis in Saccharomyces cerevisiae [1].
The activity of Sok2 as a repressor depends on phosphorylation of T598 by protein kinase A (PKA) [1].

Associations of SOK2 with chemical compounds

SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription [2].

Other interactions of SOK2

Dependence on PKA function can be partially relieved by overexpression of a gene, SOK2, whose product has significant homology with several fungal transcription factors (StuA from Aspergillus nidulans and Phd1 from Saccharomyces cerevisiae) that are associated with cellular differentiation and development [2].
The SOK2 branch was found to be effective only under conditions of high PKA activity, as in a ira1ira2 mutant, and this effect was independent of Msn2/4p [3].
Alterations in Sok2 protein production also affect the expression of genes involved in several other PKA-regulated processes, including glycogen accumulation (GAC1) and heat shock resistance (SSA3) [2].
The refined networks support previously unknown regulatory mechanisms downstream of SOK2 and SWI4 [4].

References

A positive regulator of mitosis, Sok2, functions as a negative regulator of meiosis in Saccharomyces cerevisiae. Shenhar, G., Kassir, Y. Mol. Cell. Biol. (2001) [Pubmed]
SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription. Ward, M.P., Gimeno, C.J., Fink, G.R., Garrett, S. Mol. Cell. Biol. (1995) [Pubmed]
Combinatorial control by the protein kinases PKA, PHO85 and SNF1 of transcriptional induction of the Saccharomyces cerevisiae GSY2 gene at the diauxic shift. Enjalbert, B., Parrou, J.L., Teste, M.A., François, J. Mol. Genet. Genomics (2004) [Pubmed]
Validation and refinement of gene-regulatory pathways on a network of physical interactions. Yeang, C.H., Mak, H.C., McCuine, S., Workman, C., Jaakkola, T., Ideker, T. Genome Biol. (2005) [Pubmed]

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