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Gene Review

SOK2  -  Sok2p

Saccharomyces cerevisiae S288c

Synonyms: Protein SOK2, YM9711.03C, YMR016C
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High impact information on SOK2

  • We show that Sok2 associates with Msn2 [1].
  • Relief of repression of Sok2 depends on both the N-terminal domain of Sok2 and Ime1 [1].
  • Previously it was reported that overexpression of Sok2 suppresses the growth defect resulting from a temperature-sensitive PKA; thus Sok2 has a positive role in mitosis [1].
  • We show that in the presence of glucose IREu functions as a negative element and that Sok2 mediates this repression activity [1].
  • Our results demonstrate that Sok2, a positive regulator of mitosis, and Efg1, a positive regulator of filamentation, function as negative regulators of meiosis [1].

Biological context of SOK2


Associations of SOK2 with chemical compounds

  • SOK2 may regulate cyclic AMP-dependent protein kinase-stimulated growth and pseudohyphal development by repressing transcription [2].

Other interactions of SOK2

  • Dependence on PKA function can be partially relieved by overexpression of a gene, SOK2, whose product has significant homology with several fungal transcription factors (StuA from Aspergillus nidulans and Phd1 from Saccharomyces cerevisiae) that are associated with cellular differentiation and development [2].
  • The SOK2 branch was found to be effective only under conditions of high PKA activity, as in a ira1ira2 mutant, and this effect was independent of Msn2/4p [3].
  • Alterations in Sok2 protein production also affect the expression of genes involved in several other PKA-regulated processes, including glycogen accumulation (GAC1) and heat shock resistance (SSA3) [2].
  • The refined networks support previously unknown regulatory mechanisms downstream of SOK2 and SWI4 [4].


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