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Gene Review

GLC8  -  Glc8p

Saccharomyces cerevisiae S288c

Synonyms: Protein GLC8, YM9924.03C, YMR311C
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High impact information on GLC8

  • Mutations in the yeast Aurora, Ipl1, are suppressed by overexpression of Glc8, the yeast homolog of phosphatase inhibitor-2 (I-2) [1].
  • Interestingly, overexpression as well as deletion of the GLC8 gene results in a partial suppression of the temperature-sensitive growth phenotype of ipl1ts mutants and also moderately reduces the amount of protein phosphatase 1 activity which is assayable in crude yeast lysates [2].
  • In addition, the chromosome missegregation phenotype caused by an increase in the dosage of GLC7 is totally suppressed by the glc8-delta 101::LEU2 deletion mutation [2].
  • Furthermore, site-directed mutagenesis studies of GLC8 suggest that Thr-118 of the Glc8 protein, which is equivalent to Thr-72 of inhibitor 2, may play a central role in the ability of this protein to activate and/or inhibit PP1C in vivo [2].
  • Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1 [2].

Biological context of GLC8


Anatomical context of GLC8


Associations of GLC8 with chemical compounds

  • GLC8 encodes a homologue of type 1 protein phosphatase inhibitor-2 [4].
  • These results are consistent with glucose repression of Glc8 expression and favor the role of Glc8 as a major Glc7 activator [5].

Other interactions of GLC8

  • Deletion of the aforementioned regulatory subunits revealed that only Glc8 deletion had a significant effect in reducing Glc7 activity [5].
  • In vitro kinase assays and genetic results indicate that Pho85 cyclins Pcl6 and Pcl7 comprise the predominant Glc8 kinase [3].
  • Furthermore, glc7-R121K is also lethal when combined with deletions of pcl6, plc7, pcl8, and pcl10, indicating that these related cyclins redundantly activate Pho85 for Glc8 phosphorylation in vivo [3].


  1. Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Satinover, D.L., Leach, C.A., Stukenberg, P.T., Brautigan, D.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. Tung, H.Y., Wang, W., Chan, C.S. Mol. Cell. Biol. (1995) [Pubmed]
  3. Pho85 phosphorylates the Glc7 protein phosphatase regulator Glc8 in vivo. Tan, Y.S., Morcos, P.A., Cannon, J.F. J. Biol. Chem. (2003) [Pubmed]
  4. Characterization of glycogen-deficient glc mutants of Saccharomyces cerevisiae. Cannon, J.F., Pringle, J.R., Fiechter, A., Khalil, M. Genetics (1994) [Pubmed]
  5. Glc8 is a glucose-repressible activator of Glc7 protein phosphatase-1. Nigavekar, S.S., Tan, Y.S., Cannon, J.F. Arch. Biochem. Biophys. (2002) [Pubmed]
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