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Gene Review:

CATR1 - CATR tumorigenicity conversion 1

Homo sapiens

Synonyms: CATR tumorigenic conversion 1 protein, CATR1.3

Li, D. et al., Li, D. et al., Milo, G.E. et al., Lórenz-Fonfría, V.A. et al., Sympson, G.M.

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Disease relevance of CATR1

Epstein-Barr virus growth-transformed cells are converted to malignancy following transfection of a 1.3-kb CATR1 antisense construct independent of a change in the level of c-myc expression followed by a 8;14 chromosomal translocation [1].
When the cells were transfected with a 1.3-kb CATR1 antisense cDNA construct, progressively growing lymphomas could be induced in nude mice [1].

High impact information on CATR1

These data suggest that the malignant transformation of the EBV growth-transformed cells was independent of c-myc expression and suggest that the CATR1 gene may act synergistically with the chromosomal translocation facilitating the conversion of AGLCL cells from a growth-transformed state to a malignant phenotype [1].
The DNA sequence of this 1.3-kb genetic element contains a coding region for 79 amino acids and a long 3'-untranslated region and appears to be identical to CATR1.3 isolated from tumors produced by methyl methanesulfonate-converted, nontransplantable human tumor cells [2].
Cell line CATR1 expressed a single message from the integrated library representing a 1.3-kb cDNA insert that was absent from untransfected SCC cells or MMS-converted CA cells [3].
All the CATR cells have the library vector sequence integrated in their genome [3].
When solubilized in the detergent dodecyl maltoside the protein is in equilibrium between the so-called CATR and BA conformations and in a few hours it becomes nonfunctional, unable to bind either its inhibitors or its substrates [4].

Biological context of CATR1

3. The nucleotide sequence of CATR1.3 encodes a peptide of 79 amino acids, has a long 3' untranslated region, and represents an unknown gene product that was associated with the tumorigenic conversion due to the transfected expression library [3].

Analytical, diagnostic and therapeutic context of CATR1

This 1.3-kb cDNA insert was cloned by PCR amplification of reverse-transcribed CATR1 total RNA and was designated CATR1 [3].
CATR: a new generation of autologous blood transfusion [5].

References

Epstein-Barr virus growth-transformed cells are converted to malignancy following transfection of a 1.3-kb CATR1 antisense construct independent of a change in the level of c-myc expression followed by a 8;14 chromosomal translocation. Li, D., Sun, X.L., Casto, B., Fang, J., Theil, K., Glaser, R., Milo, G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Malignant conversion of chemically transformed normal human cells. Milo, G.E., Li, D., Casto, B.C., Theil, K., Shuler, C., Noyes, I., Chen, J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Cloning and sequencing of CATR1.3, a human gene associated with tumorigenic conversion. Li, D., Noyes, I., Shuler, C., Milo, G.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
Structural and functional implications of the instability of the ADP/ATP transporter purified from mitochondria as revealed by FTIR spectroscopy. Lórenz-Fonfría, V.A., Villaverde, J., Trézéguet, V., Lauquin, G.J., Brandolin, G., Padrós, E. Biophys. J. (2003) [Pubmed]
CATR: a new generation of autologous blood transfusion. Sympson, G.M. Critical care nurse. (1991) [Pubmed]

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