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Chemical Compound Review

SureCN411624     (2R,3R,4S,5S,6R)-2- [(2R,3S,4R,5R,6R)-6...

Synonyms: D4641_SIGMA, D5172_SIGMA, AR-1I6932, AKOS016011222, FT-0625578, ...
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Disease relevance of Dodecyl-beta-D-maltoside


High impact information on Dodecyl-beta-D-maltoside


Chemical compound and disease context of Dodecyl-beta-D-maltoside


Biological context of Dodecyl-beta-D-maltoside

  • The stability of DsbB is around 4.4 kcal/mol in DM, and this is halved upon reduction of the two periplasmic disulfide bonds, and is sensitive to mutagenesis [11].
  • However, the metarhodopsin state is not stable as purified in dodecyl maltoside but decays with kinetics that require a double-exponential fit having lifetimes of 280 and 2700 s [12].
  • The tightly bound pool of the enzymes could be differentially solubilized under conditions leaving the electron transport system intact and with the nondenaturing zwitterionic detergent 3-(3-cholamidopropyl) dimethylammonio 1-propane-sulfonic acid (CHAPS) and the nonionic detergent dodecyl beta-D-maltoside [13].
  • The IC50 values are 7.4-14.8 microM for 6,6'-diester-trehaloses (C8 to C12), 14.6-21.6 microM 4,4'-diester-trehaloses (C8 to C12), 2.9-15.0 microM for 6,6'-diamide-trehaloses (C8 to C14) and 23 microM for dodecyl-beta-D-maltoside [14].
  • The phosphorylation reaction under different bleaching conditions was also studied in a completely soluble system (using 2% dodecyl maltoside) and the pattern of phosphate incorporation into rhodopsin versus opsin was identical to that in the membrane system [15].

Anatomical context of Dodecyl-beta-D-maltoside


Associations of Dodecyl-beta-D-maltoside with other chemical compounds


Gene context of Dodecyl-beta-D-maltoside

  • CD of highly purified Pgp from human, rat and murine Pgp-overexpressing drug resistant cells revealed slight variations in the spectral shape when recorded in the presence of dodecyl maltoside (DM) [25].
  • The role of glutamic acid 181 in the bovine rhodopsin retinylidene chromophore pocket was studied by expressing E181 mutants in COS cells and measuring, as a function of time, the absorbance changes produced after excitation of lauryl maltoside pigment suspensions with 7 ns laser pulses [26].
  • Beef heart oxidase is purified in one step from mitochondrial membranes solubilized with lauryl maltoside, yielding an enzyme of purity comparable to that obtained on a yeast cytochrome c matrix [Azzi, A., Bill, K., & Broger, C. (1982) Proc. Natl. Acad. Sci. U.S.A. 79, 2447-2450] [27].
  • Spectrophotometric assay of COX activity showed a 70-90% decrease in lauryl maltoside (LM)-solubilised fibroblasts [28].
  • For example, in the presence of lauryl maltoside, reactivation of adenosine deaminase increased to 98%, while phosphoglucomutase could not be reactivated significantly [29].

Analytical, diagnostic and therapeutic context of Dodecyl-beta-D-maltoside


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  6. Differential regulation of rasGAP and neurofibromatosis gene product activities. Bollag, G., McCormick, F. Nature (1991) [Pubmed]
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  8. Isolation and purification of gap junction channels. Stauffer, K.A., Kumar, N.M., Gilula, N.B., Unwin, N. J. Cell Biol. (1991) [Pubmed]
  9. Restrictive use of detergents in the functional reconstitution of the secondary multidrug transporter LmrP. Putman, M., van Veen, H.W., Poolman, B., Konings, W.N. Biochemistry (1999) [Pubmed]
  10. Pigment-protein complexes from the photosynthetic membrane of the cyanobacterium Synechocystis sp. PCC 6803. Barbato, R., Polverino De Laureto, P., Rigoni, F., De Martini, E., Giacometti, G.M. Eur. J. Biochem. (1995) [Pubmed]
  11. Folding of DsbB in mixed micelles: a kinetic analysis of the stability of a bacterial membrane protein. Otzen, D.E. J. Mol. Biol. (2003) [Pubmed]
  12. Characterization of the primary photointermediates of Drosophila rhodopsin. Vought, B.W., Salcedo, E., Chadwell, L.V., Britt, S.G., Birge, R.R., Knox, B.E. Biochemistry (2000) [Pubmed]
  13. Removal of CO dehydrogenase from Pseudomonas carboxydovorans cytoplasmic membranes, rebinding of CO dehydrogenase to depleted membranes, and restoration of respiratory activities. Jacobitz, S., Meyer, O. J. Bacteriol. (1989) [Pubmed]
  14. Disaccharide esters screened for inhibition of tumor necrosis factor-alpha release are new anti-cancer agents. Okabe, S., Suganuma, M., Tada, Y., Ochiai, Y., Sueoka, E., Kohya, H., Shibata, A., Takahashi, M., Mizutani, M., Matsuzaki, T., Fujiki, H. Jpn. J. Cancer Res. (1999) [Pubmed]
  15. Phosphorylation of solubilised dark-adapted rhodopsin. Insights into the activation of rhodopsin kinase. Dean, K.R., Akhtar, M. Eur. J. Biochem. (1993) [Pubmed]
  16. Detergent extraction identifies different VirB protein subassemblies of the type IV secretion machinery in the membranes of Agrobacterium tumefaciens. Krall, L., Wiedemann, U., Unsin, G., Weiss, S., Domke, N., Baron, C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. The plastid ndh genes code for an NADH-specific dehydrogenase: isolation of a complex I analogue from pea thylakoid membranes. Sazanov, L.A., Burrows, P.A., Nixon, P.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  18. Purification of 2,3-oxidosqualene cyclase from rat liver. Moore, W.R., Schatzman, G.L. J. Biol. Chem. (1992) [Pubmed]
  19. F1F0-ATP synthase from bovine heart mitochondria: development of the purification of a monodisperse oligomycin-sensitive ATPase. Lutter, R., Saraste, M., van Walraven, H.S., Runswick, M.J., Finel, M., Deatherage, J.F., Walker, J.E. Biochem. J. (1993) [Pubmed]
  20. Solution NMR spectroscopy of [alpha -15N]lysine-labeled rhodopsin: The single peak observed in both conventional and TROSY-type HSQC spectra is ascribed to Lys-339 in the carboxyl-terminal peptide sequence. Klein-Seetharaman, J., Reeves, P.J., Loewen, M.C., Getmanova, E.V., Chung, J., Schwalbe, H., Wright, P.E., Khorana, H.G. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  21. Structure and function in rhodopsin: the fate of opsin formed upon the decay of light-activated metarhodopsin II in vitro. Sakamoto, T., Khorana, H.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  22. Efficient purification and reconstitution of P-glycoprotein for functional and structural studies. Dong, M., Penin, F., Baggetto, L.G. J. Biol. Chem. (1996) [Pubmed]
  23. Photosystem II particles from Chlamydomonas reinhardtii. Purification, molecular weight, small subunit composition, and protein phosphorylation. de Vitry, C., Diner, B.A., Popo, J.L. J. Biol. Chem. (1991) [Pubmed]
  24. Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps. James, S.R., Paterson, A., Harden, T.K., Downes, C.P. J. Biol. Chem. (1995) [Pubmed]
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  26. Time-resolved photointermediate changes in rhodopsin glutamic acid 181 mutants. Lewis, J.W., Szundi, I., Kazmi, M.A., Sakmar, T.P., Kliger, D.S. Biochemistry (2004) [Pubmed]
  27. Lipid and subunit III depleted cytochrome c oxidase purified by horse cytochrome c affinity chromatography in lauryl maltoside. Thompson, D.A., Ferguson-Miller, S. Biochemistry (1983) [Pubmed]
  28. Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome. Pecina, P., Capková, M., Chowdhury, S.K., Drahota, Z., Dubot, A., Vojtísková, A., Hansíková, H., Houst'ková, H., Zeman, J., Godinot, C., Houstek, J. Biochim. Biophys. Acta (2003) [Pubmed]
  29. The effects of lauryl maltoside on the reactivation of several enzymes after treatment with guanidinium chloride. Tandon, S., Horowitz, P. Biochim. Biophys. Acta (1988) [Pubmed]
  30. Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 A resolution. Williams, K.A., Geldmacher-Kaufer, U., Padan, E., Schuldiner, S., Kühlbrandt, W. EMBO J. (1999) [Pubmed]
  31. Selective removal of subunit VIb increases the activity of cytochrome c oxidase. Weishaupt, A., Kadenbach, B. Biochemistry (1992) [Pubmed]
  32. Purification and characterization of oxygen-evolving photosystem II core complexes from the green alga Chlamydomonas reinhardtii. Bumann, D., Oesterhelt, D. Biochemistry (1994) [Pubmed]
  33. Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1. Altenbach, C., Klein-Seetharaman, J., Cai, K., Khorana, H.G., Hubbell, W.L. Biochemistry (2001) [Pubmed]
  34. Light-harvesting complex II pigments and proteins in association with Cbr, a homolog of higher-plant early light-inducible proteins in the unicellular green alga Dunaliella. Banet, G., Pick, U., Zamir, A. Planta (2000) [Pubmed]
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