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Gene Review

VNN1  -  vanin 1

Homo sapiens

Synonyms: HDLCQ8, Pantetheinase, Pantetheine hydrolase, Tiff66, Vanin-1, ...
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Disease relevance of VNN1


High impact information on VNN1


Biological context of VNN1

  • The results indicate that the active site of pantetheine hydrolase is labile and unfolds under conditions in which no global tertiary structure modifications can be observed [3].

Anatomical context of VNN1

  • We report here the identification of two distinct human cDNAs, called VNN1 and VNN2, related to the recently described mouse Vanin-1 molecule involved in lymphocyte migration (M. Aurrand-Lions et al., 1996, Immunity 5: 391-405) [4].

Associations of VNN1 with chemical compounds

  • The effect of many thiol reagents and disulfides on pantetheinase (E.C. 3.5.1.-; pantetheine hydrolase) was studied in the presence or absence of S-pantetheine-3-pyruvate as substrate [5].


  1. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor {gamma} activity. Berruyer, C., Pouyet, L., Millet, V., Martin, F.M., Legoffic, A., Canonici, A., Garcia, S., Bagnis, C., Naquet, P., Galland, F. J. Exp. Med. (2006) [Pubmed]
  2. A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. Suzuki, K., Watanabe, T., Sakurai, S., Ohtake, K., Kinoshita, T., Araki, A., Fujita, T., Takei, H., Takeda, Y., Sato, Y., Yamashita, T., Araki, Y., Sendo, F. J. Immunol. (1999) [Pubmed]
  3. Conformational changes at the active site of pantetheine hydrolase during denaturation by guanidine hydrochloride. Pitari, G., D'Archivio, A.A., Di Leandro, L., Antonini, G., Panatta, A., Tettamanti, E., Duprè, S., Malatesta, F. J. Protein Chem. (1999) [Pubmed]
  4. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. Galland, F., Malergue, F., Bazin, H., Mattei, M.G., Aurrand-Lions, M., Theillet, C., Naquet, P. Genomics (1998) [Pubmed]
  5. Interaction of pantetheinase with sulfhydryl reagents and disulfides. Ricci, G., Nardini, M., Chiaraluce, R., Duprè, S., Cavallini, D. Biochim. Biophys. Acta (1986) [Pubmed]
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