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Gene Review

VNN2  -  vanin 2

Homo sapiens

Synonyms: FOAP-4, GPI-80, Glycosylphosphatidyl inositol-anchored protein GPI-80, Protein FOAP-4, Vanin-2, ...
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High impact information on VNN2


Biological context of VNN2


Anatomical context of VNN2

  • We report here the identification of two distinct human cDNAs, called VNN1 and VNN2, related to the recently described mouse Vanin-1 molecule involved in lymphocyte migration (M. Aurrand-Lions et al., 1996, Immunity 5: 391-405) [8].
  • To verify this, we examined whether GPI-80 is expressed on the human promyelocytic leukemia cell line HL-60 following treatment with differentiation inducers [2].
  • Thus, we identify secretory vesicles as the reservoir of GPI-80 from which it may translocate to the plasma membrane after weak stimulation of the cells [9].
  • Increasing amounts of GPI-80 were exposed on the cell surface after weak stimulation with the chemoattractant fMLF, suggesting that the protein can be translocated to the plasma membrane from intracellular stores [9].
  • In contrast, GPI-80 expression was low in HLA-DQ-positive monocytes [4].

Associations of VNN2 with chemical compounds


Other interactions of VNN2


Analytical, diagnostic and therapeutic context of VNN2


  1. A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: a possible role for regulation of neutrophil adherence and migration. Suzuki, K., Watanabe, T., Sakurai, S., Ohtake, K., Kinoshita, T., Araki, A., Fujita, T., Takei, H., Takeda, Y., Sato, Y., Yamashita, T., Araki, Y., Sendo, F. J. Immunol. (1999) [Pubmed]
  2. Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells. Takeda, Y., Fu, J., Suzuki, K., Sendo, D., Nitto, T., Sendo, F., Araki, Y. Exp. Cell Res. (2003) [Pubmed]
  3. GPI-80, a beta2 integrin associated glycosylphosphatidylinositol-anchored protein, concentrates on pseudopodia without association with beta2 integrin during neutrophil migration. Yoshitake, H., Takeda, Y., Nitto, T., Sendo, F., Araki, Y. Immunobiology (2003) [Pubmed]
  4. Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes. Sendo, D., Takeda, Y., Ishikawa, H., Sendo, F., Araki, Y. Immunobiology (2003) [Pubmed]
  5. Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage. Sasaki, H., Ide, N., Sendo, F., Takeda, Y., Adachi, M., Fukai, I., Fujii, Y. Cancer Sci. (2003) [Pubmed]
  6. Cross-linking of GPI-80, a possible regulatory molecule of cell adhesion, induces up-regulation of CD11b/CD18 expression on neutrophil surfaces and shedding of L-selectin. Yoshitake, H., Takeda, Y., Nitto, T., Sendo, F. J. Leukoc. Biol. (2002) [Pubmed]
  7. Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs). Batista, E.L., Warbington, M., Badwey, J.A., Van Dyke, T.E. J. Cell. Biochem. (2005) [Pubmed]
  8. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. Galland, F., Malergue, F., Bazin, H., Mattei, M.G., Aurrand-Lions, M., Theillet, C., Naquet, P. Genomics (1998) [Pubmed]
  9. Neutrophil secretory vesicles are the intracellular reservoir for GPI-80, a protein with adhesion-regulating potential. Dahlgren, C., Karlsson, A., Sendo, F. J. Leukoc. Biol. (2001) [Pubmed]
  10. Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils. Nitto, T., Araki, Y., Takeda, Y., Sendo, F. Br. J. Pharmacol. (2002) [Pubmed]
  11. Clustering on the forward surfaces of migrating neutrophils of a novel GPI-anchored protein that may regulate neutrophil adherence and migration. Nakamura-Sato, Y., Sasaki, K., Watanabe, H., Araki, Y., Sendo, F. J. Leukoc. Biol. (2000) [Pubmed]
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