The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

BAIAP3  -  BAI1-associated protein 3

Homo sapiens

Synonyms: BAP3, KIAA0734
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on BAIAP3

  • Using a two-hybrid system, we isolated a cDNA encoding a product that interacts with the cytoplasmic region of BAI1 and designated it BAP3 (BAI1-associated protein 3) [1].
  • Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1 [1].
  • The BAP3 product is a novel C2 domain-containing molecule with homology to Munc13 and synaptotagmin [1].
  • One mAb, BAP-3, was found to react with all six individually expressed PSGs representing five alternatively spliced forms, but not with any of the seven expressed members of the carcinoembryonic antigen (CEA) subfamily [2].
  • The BAP-3 epitope is located in the PSG B2 domain [2].

Biological context of BAIAP3


Associations of BAIAP3 with chemical compounds

  • Deletion-mutant analysis revealed that the interaction between BAI1 and BAP3 was not mediated by the C2 domains [1].

Physical interactions of BAIAP3

  • The BAIAP3 promoter is specifically bound in vivo by the (-KTS) isoform of EWS-WT1, consistent with its activation in reporter assays [3].

Other interactions of BAIAP3


  1. Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. Shiratsuchi, T., Oda, K., Nishimori, H., Suzuki, M., Takahashi, E., Tokino, T., Nakamura, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  2. Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta. Zhou, G.Q., Baranov, V., Zimmermann, W., Grunert, F., Erhard, B., Mincheva-Nilsson, L., Hammarström, S., Thompson, J. Placenta (1997) [Pubmed]
  3. Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis. Palmer, R.E., Lee, S.B., Wong, J.C., Reynolds, P.A., Zhang, H., Truong, V., Oliner, J.D., Gerald, W.L., Haber, D.A. Cancer Cell (2002) [Pubmed]
WikiGenes - Universities