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Gene Review:

ECs5106 - DcuR family transcriptional regulator

Escherichia coli O157:H7 str. Sakai

Golby, P. et al., Abo-Amer, A.E. et al., Janausch, I.G. et al., Janausch, I.G. et al., Zientz, E. et al.

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Disease relevance of ECs5106

Identification and characterization of a two-component sensor-kinase and response-regulator system (DcuS-DcuR) controlling gene expression in response to C4-dicarboxylates in Escherichia coli [1].
Database searches showed that DcuS and DcuR are closely related to a subgroup of two-component sensor-regulators that includes the citrate-responsive CitA-CitB system of Klebsiella pneumoniae [1].

High impact information on ECs5106

The phosphoryl group of DcuS was rapidly transferred to the response regulator DcuR [2].
Both of the phosphorylated DcuS constructs were able to rapidly pass their phosphoryl groups to DcuR, and after phosphorylation, DcuR dephosphorylated rapidly [3].
The DcuS-DcuR system of Escherichia coli is a two-component sensor-regulator that controls gene expression in response to external C(4)-dicarboxylates and citrate [3].
The binding sites were located by DNase I footprinting, allowing a putative DcuR-binding motif [tandemly repeated (T/A)(A/T)(T/C)(A/T)AA sequences] to be identified [3].
Fumarate stimulation was independent of the fumarate response regulator DcuR [4].

Chemical compound and disease context of ECs5106

Phosphorylation and DNA binding of the regulator DcuR of the fumarate-responsive two-component system DcuSR of Escherichia coli [5].

Biological context of ECs5106

The yjdHG genes (redesignated dcuSR) appear to constitute an operon encoding a two-component sensor-regulator system (DcuS-DcuR) [1].

Associations of ECs5106 with chemical compounds

Isolated DcuR protein was phosphorylated by the sensory histidine kinase, DcuS, and ATP, or by acetyl phosphate [5].

References

Identification and characterization of a two-component sensor-kinase and response-regulator system (DcuS-DcuR) controlling gene expression in response to C4-dicarboxylates in Escherichia coli. Golby, P., Davies, S., Kelly, D.J., Guest, J.R., Andrews, S.C. J. Bacteriol. (1999) [Pubmed]
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro. Janausch, I.G., Garcia-Moreno, I., Unden, G. J. Biol. Chem. (2002) [Pubmed]
DNA interaction and phosphotransfer of the C4-dicarboxylate-responsive DcuS-DcuR two-component regulatory system from Escherichia coli. Abo-Amer, A.E., Munn, J., Jackson, K., Aktas, M., Golby, P., Kelly, D.J., Andrews, S.C. J. Bacteriol. (2004) [Pubmed]
Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli. Zientz, E., Janausch, I.G., Six, S., Unden, G. J. Bacteriol. (1999) [Pubmed]
Phosphorylation and DNA binding of the regulator DcuR of the fumarate-responsive two-component system DcuSR of Escherichia coli. Janausch, I.G., Garcia-Moreno, I., Lehnen, D., Zeuner, Y., Unden, G. Microbiology (Reading, Engl.) (2004) [Pubmed]

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