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Gene Review

ECs4886  -  acetylornithine deacetylase

Escherichia coli O157:H7 str. Sakai

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  • Three of the enzymes of arginine biosynthesis, acetylornithinase, ornithine transcarbamylase, and argininosuccinase, show a greater rate of derepression and a 2--12-fold higher level of enzyme activity in the rifampin-resistant mutant than in the parent arginine-inducible strain [8].


  1. Accumulation of arginine precursors in Escherichia coli: effects on growth, enzyme repression, and application to the forward selection of arginine auxotrophs. Crabeel, M., Charlier, D., Cunin, R., Boyen, A., Glansdorff, N., Piérard, A. J. Bacteriol. (1975) [Pubmed]
  2. Acetylornithine deacetylase, succinyldiaminopimelate desuccinylase and carboxypeptidase G2 are evolutionarily related. Boyen, A., Charlier, D., Charlier, J., Sakanyan, V., Mett, I., Glansdorff, N. Gene (1992) [Pubmed]
  3. Evolution of arginine biosynthesis in the bacterial domain: novel gene-enzyme relationships from psychrophilic Moritella strains (Vibrionaceae) and evolutionary significance of N-alpha-acetyl ornithinase. Xu, Y., Liang, Z., Legrain, C., Rüger, H.J., Glansdorff, N. J. Bacteriol. (2000) [Pubmed]
  4. Effects of apocynin and natural antioxidant from spinach on inducible nitric oxide synthase and cyclooxygenase-2 induction in lipopolysaccharide-induced hepatic injury in rat. Lomnitski, L., Foley, J.E., Grossman, S., Shaul, V.B., Maronpot, R.R., Moomaw, C.R., Carbonatto, M., Nyska, A. Pharmacol. Toxicol. (2000) [Pubmed]
  5. argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli contains a dinuclear metalloactive site. McGregor, W.C., Swierczek, S.I., Bennett, B., Holz, R.C. J. Am. Chem. Soc. (2005) [Pubmed]
  6. A new locus (leuK) affecting the regulation of branched-chain amino acid, histidine, and tryptophan biosynthetic enzymes. Brown, C.S., West, R., Hilderman, R.H., Bayliss, F.T., Klines, E.L. J. Bacteriol. (1978) [Pubmed]
  7. Genes and enzymes of the acetyl cycle of arginine biosynthesis in the extreme thermophilic bacterium Thermus thermophilus HB27. Baetens, M., Legrain, C., Boyen, A., Glansdorff, N. Microbiology (Reading, Engl.) (1998) [Pubmed]
  8. Alteration of regulation of arginine biosynthesis in Escherichia coli W by mutation to rifampin resistance. Wozny, M.E., Carnevale, H.N., Jones, E.E. Biochim. Biophys. Acta (1975) [Pubmed]
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