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Chemical Compound Review

AG-L-66335     2-acetamido-5-amino-pentanoic acid

Synonyms: A3626_SIGMA, AC1L1AAN, AC1Q5KZY, CTK8G1598, AR-1K4904, ...
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Disease relevance of N-acetylornithine


High impact information on N-acetylornithine


Chemical compound and disease context of N-acetylornithine


Biological context of N-acetylornithine


Anatomical context of N-acetylornithine


Gene context of N-acetylornithine

  • The cDNA encoding for the protein was cloned based on its amino-terminal sequence and the amino acid sequence deduced from the determined nucleotide sequences of the cDNA exhibited homology to the enzymes belong to the ArgE/DapE/Acy1/Cpg2/YscS protein family (including acetylornithine deacetylase, carboxypeptidase and aminoacylase-1) [11].
  • Additionally, using the knot detection algorithm on structures in the Protein Data Bank, a previously unreported deep trefoil knot was found in acetylornithine transcarbamylase [12].


  1. Ornithine delta-transaminase activity in Escherichia coli: its identity with acetylornithine delta-transaminase. Billhemier, J.T., Carnevale, H.N., Leisinger, T., Eckhardt, T., Jones, E.E. J. Bacteriol. (1976) [Pubmed]
  2. Identification and characterization of the Myxococcus xanthus argE gene. Harris, B.Z., Singer, M. J. Bacteriol. (1998) [Pubmed]
  3. Immunochemical studies on acetylornithine 5-aminotransferase from Pseudomonas aeruginosa. Voellmy, R., Utzinger, R. Experientia (1977) [Pubmed]
  4. Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria. Shi, D., Morizono, H., Yu, X., Roth, L., Caldovic, L., Allewell, N.M., Malamy, M.H., Tuchman, M. J. Biol. Chem. (2005) [Pubmed]
  5. Nitrogen metabolism in actinorhizal nodules of Alnus glutinosa: expression of glutamine synthetase and acetylornithine transaminase. Guan, C., Ribeiro, A., Akkermans, A.D., Jing, Y., van Kammen, A., Bisseling, T., Pawlowski, K. Plant Mol. Biol. (1996) [Pubmed]
  6. Gene cloning, sequence analysis, purification, and characterization of a thermostable aminoacylase from Bacillus stearothermophilus. Sakanyan, V., Desmarez, L., Legrain, C., Charlier, D., Mett, I., Kochikyan, A., Savchenko, A., Boyen, A., Falmagne, P., Pierard, A. Appl. Environ. Microbiol. (1993) [Pubmed]
  7. Cloning the Escherichia coli K-12 argD gene specifying acetylornithine delta-transaminase. Riley, M., Glansdorff, N. Gene (1983) [Pubmed]
  8. Alteration of regulation of arginine biosynthesis in Escherichia coli W by mutation to rifampin resistance. Wozny, M.E., Carnevale, H.N., Jones, E.E. Biochim. Biophys. Acta (1975) [Pubmed]
  9. Characterization of the Saccharomyces cerevisiae ARG7 gene encoding ornithine acetyltransferase, an enzyme also endowed with acetylglutamate synthase activity. Crabeel, M., Abadjieva, A., Hilven, P., Desimpelaere, J., Soetens, O. Eur. J. Biochem. (1997) [Pubmed]
  10. N-delta-acetylornithine and S-methylcysteine in blood plasma. Armstrong, M.D. Biochim. Biophys. Acta (1979) [Pubmed]
  11. Responses of wild watermelon to drought stress: accumulation of an ArgE homologue and citrulline in leaves during water deficits. Kawasaki, S., Miyake, C., Kohchi, T., Fujii, S., Uchida, M., Yokota, A. Plant Cell Physiol. (2000) [Pubmed]
  12. Rapid knot detection and application to protein structure prediction. Khatib, F., Weirauch, M.T., Rohl, C.A. Bioinformatics (2006) [Pubmed]
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