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Gene Review

HTR3B  -  5-hydroxytryptamine (serotonin) receptor...

Homo sapiens

Synonyms: 5-HT3-B, 5-HT3B, 5-hydroxytryptamine receptor 3B, Serotonin receptor 3B
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Disease relevance of HTR3B


Psychiatry related information on HTR3B


High impact information on HTR3B

  • Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B [4].
  • CONCLUSIONS: Our results suggest an important role for HTR3B in major depression in women and also raise the possibility that previously proposed disease-associated SNPs in the HTR3A/B region in Caucasians are in linkage disequilibrium with haplotype block 2 of HTR3B in the Japanese [3].
  • In HTR3B, haplotype block 2 that included a nonsynonymous single nucleotide polymorphism (SNP), yielded evidence of association with major depression in females (global p = .0023) [3].
  • Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine [5].
  • According to these experiments, two alternative promoters control the expression of different HTR3B transcripts in the peripheral and central nervous system [5].

Biological context of HTR3B

  • RESULTS: Two haplotype blocks each were revealed for HTR3A and HTR3B in Japanese samples [3].
  • BACKGROUND: Genetic variations in the serotonin receptor 3A (HTR3A) and 3B (HTR3B) genes, positioned in tandem on chromosome 11q23.2, have been shown to be associated with psychiatric disorders in samples of European ancestry [3].
  • The HTR3B transcription start site is not unequivocally identified [5].
  • In this study, we tested the influence of the serotonin type 2A, 3A and 3B receptor genes (HTR2A, HTR3A, HTR3B) in addition to a polymorphism in the promoter region of the serotonin transporter (SERTPR), and investigated the different characteristics of clinical responses to paroxetine and fluvoxamine [6].
  • Screening of 49 patients suffering from BPAD, 78 patients with SZ and 62 control individuals revealed eleven sequence variations including a 3 bp deletion within the 5'UTR (5' untranslated region), four exonic and five intronic SNPs as well as a point mutation in the 3'UTR of HTR3B [7].

Associations of HTR3B with chemical compounds

  • In our study both serotonin receptor subunit genes, HTR3A and HTR3B, were examined for sequence variations in GTS patients [2].

Other interactions of HTR3B

  • In HTR3A, we detected five mutations and in HTR3B the analysis revealed six sequence variants [2].

Analytical, diagnostic and therapeutic context of HTR3B


  1. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. Frank, B., Niesler, B., Bondy, B., Späth, M., Pongratz, D.E., Ackenheil, M., Fischer, C., Rappold, G. Clin. Rheumatol. (2004) [Pubmed]
  2. Serotonin receptor genes HTR3A and HTR3B are not involved in Gilles de la Tourette syndrome. Niesler, B., Frank, B., Hebebrand, J., Rappold, G. Psychiatr. Genet. (2005) [Pubmed]
  3. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. Yamada, K., Hattori, E., Iwayama, Y., Ohnishi, T., Ohba, H., Toyota, T., Takao, H., Minabe, Y., Nakatani, N., Higuchi, T., Detera-Wadleigh, S.D., Yoshikawa, T. Biol. Psychiatry (2006) [Pubmed]
  4. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. Melke, J., Westberg, L., Nilsson, S., Landen, M., Soderstrom, H., Baghaei, F., Rosmond, R., Holm, G., Björntorp, P., Nilsson, L.G., Adolfsson, R., Eriksson, E. Arch. Gen. Psychiatry (2003) [Pubmed]
  5. Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. Tzvetkov, M.V., Meineke, C., Oetjen, E., Hirsch-Ernst, K., Brockm??ller, J. Gene (2007) [Pubmed]
  6. Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Kato, M., Fukuda, T., Wakeno, M., Fukuda, K., Okugawa, G., Ikenaga, Y., Yamashita, M., Takekita, Y., Nobuhara, K., Azuma, J., Kinoshita, T. Neuropsychobiology (2006) [Pubmed]
  7. Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients. Frank, B., Niesler, B., Nöthen, M.M., Neidt, H., Propping, P., Bondy, B., Rietschel, M., Maier, W., Albus, M., Rappold, G. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
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