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Gene Review

ZMYM3  -  zinc finger, MYM-type 3

Homo sapiens

Synonyms: DXS6673E, KIAA0385, MYM, XFIM, ZNF198L2, ...
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Disease relevance of ZMYM3

  • ZNF261 at Xq13.1 is disrupted by a t(X;13)(q13.1;q32) rearrangement in a mentally retarded patient and is a candidate gene for nonspecific X-linked mental retardation [1].
  • The mean daily protein and caloric consumption (per kg body weight) by the children in both groups (at 3.4 gm of proteins and 83 calories for the MYMP group and 3.9 gm of protein and 101 calories for the TYMP group) were not significantly different [2].

Psychiatry related information on ZMYM3


High impact information on ZMYM3

  • Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1 [4].
  • Almost complete sequence identity was found between the 3' end of the DXS6673E gene and two expressed sequence tags (ESTs) and between the 5' end of the DXS6673E gene and a third EST [4].
  • Here, we report on the cloning and characterization of a novel gene, DXS6673E, that maps to Xq13.1, is subject to X-inactivation and is disrupted in the 5' untranslated region by a balanced X;13 translocation in a mentally retarded female [4].
  • AFX1 is flanked by loci DXS7116 and Il2R gamma, and p54nrb by loci DXS6673E and DXS7120 [5].
  • It is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing, including a large 382 amino acid form containing a single MYM domain, and 2 shorter forms of 208 and 213 amino acids respectively that do not [6].

Biological context of ZMYM3


Analytical, diagnostic and therapeutic context of ZMYM3

  • The rehabilitation period for the TYMP group (15 days) was significantly (p > 0.05) lower than that for the MYMP group which was 20 days [2].


  1. Cloning and mapping of members of the MYM family. Smedley, D., Hamoudi, R., Lu, Y.J., Cooper, C., Shipley, J. Genomics (1999) [Pubmed]
  2. Effect of tempe-yellow maize porridge and milk-yellow maize porridge on growth rate, diarrhoea and duration of rehabilitation of malnourished children. Kalavi, F.N., Muroki, N.M., Omwega, A.M., Mwadime, R.K. East African medical journal. (1996) [Pubmed]
  3. The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Raffa, G.D., Cenci, G., Siriaco, G., Goldberg, M.L., Gatti, M. Mol. Cell (2005) [Pubmed]
  4. Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1. van der Maarel, S.M., Scholten, I.H., Huber, I., Philippe, C., Suijkerbuijk, R.F., Gilgenkrantz, S., Kere, J., Cremers, F.P., Ropers, H.H. Hum. Mol. Genet. (1996) [Pubmed]
  5. AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism. Peters, U., Haberhausen, G., Kostrzewa, M., Nolte, D., Müller, U. Hum. Genet. (1997) [Pubmed]
  6. Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM. Pastorcic, M., Das, H.K. Brain Res. (2007) [Pubmed]
  7. Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13). Popovici, C., Adélaïde, J., Ollendorff, V., Chaffanet, M., Guasch, G., Jacrot, M., Leroux, D., Birnbaum, D., Pébusque, M.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Methylation of ZNF261 as an assay for determining X chromosome inactivation patterns. Beever, C., Lai, B.P., Baldry, S.E., Peñaherrera, M.S., Jiang, R., Robinson, W.P., Brown, C.J. Am. J. Med. Genet. A (2003) [Pubmed]
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