Disease relevance of UBE2L6

• Similarly, IFNs enhanced UbcH8 mRNA expression in A549 lung epithelial cells, HepG2 hepatoma cells, and NK-92 cells [1].

High impact information on UBE2L6

• Here, we show that Parkin binds to the E2 ubiquitin-conjugating human enzyme 8 (UbcH8) through its C-terminal ring-finger [2].
• We demonstrated that both UbcH7 and UbcH8 bind to full-length NKLAM [3].
• Staring binds and recruits the brain-enriched E2 ubiquitin-conjugating enzyme UbcH8 to syntaxin 1 and facilitates the ubiquitination and proteasome-dependent degradation of syntaxin 1 [4].
• Here we report the cloning of a new human E2, designated UbcH8, that was identified in a two-hybrid screen through specific interaction with E6AP [5].
• Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells [6].

Biological context of UBE2L6

• Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12 [7].
• From a cDNA library of human lymph nodes, a cDNA encoding the ubiquitin-conjugating enzyme UbcH8 was identified [8].

Associations of UBE2L6 with chemical compounds

• The Spen Homolog Msx2-Interacting Nuclear Target Protein Interacts with the E2 Ubiquitin-Conjugating Enzyme UbcH8 [8].

Other interactions of UBE2L6

• Dorfin bound specifically with human ubiquitin-conjugating enzymes UbcH7 and UbcH8 through the RING-finger/IBR domain [9].

Analytical, diagnostic and therapeutic context of UBE2L6

• The interaction between MINT and UbcH8 in mammalian cells was further proved by a series of biochemical assays including the mammalian two-hybrid assay, GST pull-down assay, and co-immunoprecipitation assay [8].

References