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ADAMTSL1  -  ADAMTS-like 1

Homo sapiens

Synonyms: ADAMTS-like protein 1, ADAMTSL-1, ADAMTSR1, C9orf94, FLJ35283, ...
 
 
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High impact information on ADAMTSL1

 

Associations of ADAMTSL1 with chemical compounds

  • Expression of punctin-1 in Lec-13 cells that are deficient in conversion of GDP-mannose to GDP-fucose substantially decreased the levels of secreted protein, which were restored upon culture in the presence of exogenous l-fucose [3].
 

Analytical, diagnostic and therapeutic context of ADAMTSL1

  • Recombinant epitope-tagged punctin has a calculated mass of 59,991 Da but exhibits major molecular species of 61970 +/- 6 Da and 62131 +/- 5 Da as measured by liquid chromatography electrospray mass spectrometry [1].

References

  1. Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. Hirohata, S., Wang, L.W., Miyagi, M., Yan, L., Seldin, M.F., Keene, D.R., Crabb, J.W., Apte, S.S. J. Biol. Chem. (2002) [Pubmed]
  2. The ADAMTS metalloproteinases. Porter, S., Clark, I.M., Kevorkian, L., Edwards, D.R. Biochem. J. (2005) [Pubmed]
  3. O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. Wang, L.W., Dlugosz, M., Somerville, R.P., Raed, M., Haltiwanger, R.S., Apte, S.S. J. Biol. Chem. (2007) [Pubmed]
 
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