The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Gdp mannose     [(2R,3S,4R,5R)-5-(2-amino-6- oxo-3H-purin-9...

Synonyms: GDP-glucose, GDP-mannose, GDP-D-mannose, AG-J-78856, CHEBI:15820, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of guanosine diphosphomannose

  • GDPmannose dehydrogenase and biosynthesis of alginate-like polysaccharide in a mucoid strain of Pseudomonas aeruginosa [1].
  • The genes rfbK and rfbM from the rfb cluster (O-antigen biosynthesis) of Salmonella enterica, group B, encoding for the enzymes phosphomannomutase (EC and GDP-alpha-D-mannose pyrophosphorylase (EC were overexpressed in E.coli BL21 (DE3) with specific activities of 0.1 U/mg and 0.3-0.6 U/mg, respectively [2].
  • By using the same expression system, GDPmannose dehydrogenase activity was detected in both P. aeruginosa and E. coli [3].
  • Two of the gene products showed 60-70% identity to the RfbM and RfbK proteins that are biosynthetic enzymes for the GDPmannose pathway of enterobacteria [4].
  • The algD gene encodes NAD-linked GDPmannose dehydrogenase, which is essential for the mucoid phenotype, an important virulence factor expressed by Pseudomonas aeruginosa in cystic fibrosis patients [5].

High impact information on guanosine diphosphomannose


Biological context of guanosine diphosphomannose


Anatomical context of guanosine diphosphomannose


Associations of guanosine diphosphomannose with other chemical compounds


Gene context of guanosine diphosphomannose


Analytical, diagnostic and therapeutic context of guanosine diphosphomannose


  1. GDPmannose dehydrogenase and biosynthesis of alginate-like polysaccharide in a mucoid strain of Pseudomonas aeruginosa. Pugashetti, B.K., Vadas, L., Prihar, H.S., Feingold, D.S. J. Bacteriol. (1983) [Pubmed]
  2. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Elling, L., Ritter, J.E., Verseck, S. Glycobiology (1996) [Pubmed]
  3. Gene algD coding for GDPmannose dehydrogenase is transcriptionally activated in mucoid Pseudomonas aeruginosa. Deretic, V., Gill, J.F., Chakrabarty, A.M. J. Bacteriol. (1987) [Pubmed]
  4. The gene cluster directing O-antigen biosynthesis in Yersinia enterocolitica serotype 0:8: identification of the genes for mannose and galactose biosynthesis and the gene for the O-antigen polymerase. Zhang, L., Toivanen, P., Skurnik, M. Microbiology (Reading, Engl.) (1996) [Pubmed]
  5. The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR. Mohr, C.D., Sonsteby, S.K., Deretic, V. Mol. Gen. Genet. (1994) [Pubmed]
  6. Topography of glycosylation in yeast: characterization of GDPmannose transport and lumenal guanosine diphosphatase activities in Golgi-like vesicles. Abeijon, C., Orlean, P., Robbins, P.W., Hirschberg, C.B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Pseudomonas aeruginosa infection in cystic fibrosis: nucleotide sequence and transcriptional regulation of the algD gene. Deretic, V., Gill, J.F., Chakrabarty, A.M. Nucleic Acids Res. (1987) [Pubmed]
  8. High osmolarity is a signal for enhanced algD transcription in mucoid and nonmucoid Pseudomonas aeruginosa strains. Berry, A., DeVault, J.D., Chakrabarty, A.M. J. Bacteriol. (1989) [Pubmed]
  9. A set of cassettes and improved vectors for genetic and biochemical characterization of Pseudomonas genes. Deretic, V., Chandrasekharappa, S., Gill, J.F., Chatterjee, D.K., Chakrabarty, A.M. Gene (1987) [Pubmed]
  10. Regulation of the synthesis of nucleoside diphosphate sugars in reticulo-endothelial tissues. Mendicino, J., Rao, A.K. Eur. J. Biochem. (1975) [Pubmed]
  11. Biosynthesis and characterization of large dolichyl diphosphate-linked oligosaccharides in Saccharomyces cerevisiae. Lehle, L., Tanner, W. Biochim. Biophys. Acta (1978) [Pubmed]
  12. GDPmannose dolicholphosphate mannosyltransferase of chicken liver mitochondria. Tomita, Y., Motokawa, Y. Biochim. Biophys. Acta (1985) [Pubmed]
  13. Properties of the dolichol phosphate: GDPmannose mannosyltransferase of liver microsomes. Vessey, D.A., Zatta, P., Zakim, D. Med. Biol. (1979) [Pubmed]
  14. Glycosyltransferases with endogenous acceptor activity in plasma membranes isolated from rat liver. Merritt, W.D., Morre, D.J., Franke, W.W., Keenan, T.W. Biochim. Biophys. Acta (1977) [Pubmed]
  15. GDP-mannose mannosyl hydrolase catalyzes nucleophilic substitution at carbon, unlike all other Nudix hydrolases. Legler, P.M., Massiah, M.A., Bessman, M.J., Mildvan, A.S. Biochemistry (2000) [Pubmed]
  16. Glycosyl transferase activity in homogenates of adult Dirofilaria immitis. Comley, J.C., Jaffe, J.J., Chrin, L.R. Mol. Biochem. Parasitol. (1982) [Pubmed]
  17. Topological orientation of mitochondrial GDPmannose: dolichyl-monophosphate mannosyltransferase in the outer membrane. Gasnier, F., Louisot, P., Gateau-Roesch, O. Biochim. Biophys. Acta (1989) [Pubmed]
  18. Formation of alpha-1,2- and alpha-1,3-linked mannose disaccharides from dolichyl mannosyl phosphate by rat liver membrane enzymes. Quill, H., Wolf, G. Biochim. Biophys. Acta (1981) [Pubmed]
WikiGenes - Universities