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Gene Review

FOXF1  -  forkhead box F1

Homo sapiens

Synonyms: ACDMPV, FKHL5, FREAC-1, FREAC1, Forkhead box protein F1, ...
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Disease relevance of FOXF1


High impact information on FOXF1

  • In contrast, a group of distinct proteins, including FOXF1, POD1, GLI, and HOX family members, play important roles in the developing lung mesenchyme, from which pulmonary vessels and bronchial smooth muscle develop [3].
  • The binding sites for all four FREAC proteins share a core sequence, RTAAAYA, but differ in the positions flanking the core [4].
  • We have used PCR and low stringency hybridization to isolate clones from human cDNA and genomic libraries that represent seven novel forkhead genes, freac-1 to freac-7 [4].
  • With regard to genes related to cell growth regulation, we found up-regulation of forkhead transcription factor FREAC-1, poly (A) binding protein PABP2, and Ras suppressor Rsu-1 [5].
  • The concentration of expression to subepithelial mesenchyme suggested that Foxf1 is activated by paracrine signals from endodermal epithelia [6].

Biological context of FOXF1


Anatomical context of FOXF1


Associations of FOXF1 with chemical compounds


Other interactions of FOXF1

  • Activation domain 1 consists of the most C-terminal 23 amino acids of FREAC-2 and contains a sequence motif conserved in an activation domain of another forkhead protein, FREAC-1 [12].
  • Affected genes such as FOXF1, sucrase-isomaltase, collagen, interferon, complement and thrombospondin 1 have previously been linked to CFTR function or are known to contribute to the related processes of epithelial differentiation and repair [13].


  1. Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia. Coon, D.R., Roberts, D.J., Loscertales, M., Kradin, R. Exp. Mol. Pathol. (2006) [Pubmed]
  2. Mutations in the transcription factor gene SOX18 underlie recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia. Irrthum, A., Devriendt, K., Chitayat, D., Matthijs, G., Glade, C., Steijlen, P.M., Fryns, J.P., Van Steensel, M.A., Vikkula, M. Am. J. Hum. Genet. (2003) [Pubmed]
  3. Transcriptional control of lung morphogenesis. Maeda, Y., Davé, V., Whitsett, J.A. Physiol. Rev. (2007) [Pubmed]
  4. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. Pierrou, S., Hellqvist, M., Samuelsson, L., Enerbäck, S., Carlsson, P. EMBO J. (1994) [Pubmed]
  5. Expression profiling of liver cell lines expressing entire or parts of hepatitis C virus open reading frame. Aizaki, H., Harada, T., Otsuka, M., Seki, N., Matsuda, M., Li, Y.W., Kawakami, H., Matsuura, Y., Miyamura, T., Suzuki, T. Hepatology (2002) [Pubmed]
  6. Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Mahlapuu, M., Enerbäck, S., Carlsson, P. Development (2001) [Pubmed]
  7. Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2. Hellqvist, M., Mahlapuu, M., Samuelsson, L., Enerbäck, S., Carlsson, P. J. Biol. Chem. (1996) [Pubmed]
  8. Transcription factor FOXF1 regulates growth hormone variant gene expression. Lomenick, J.P., Hubert, M.A., Handwerger, S. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  9. FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces. Mahlapuu, M., Pelto-Huikko, M., Aitola, M., Enerbäck, S., Carlsson, P. Dev. Biol. (1998) [Pubmed]
  10. Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12). Larsson, C., Hellqvist, M., Pierrou, S., White, I., Enerbäck, S., Carlsson, P. Genomics (1995) [Pubmed]
  11. The grape-derived polyphenol resveratrol differentially affects epidermal and platelet-derived growth factor signaling in human liver myofibroblasts. Godichaud, S., Si-Tayeb, K., Augé, N., Desmoulière, A., Balabaud, C., Payrastre, B., Nègre-Salvayre, A., Rosenbaum, J. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  12. The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. Hellqvist, M., Mahlapuu, M., Blixt, A., Enerbäck, S., Carlsson, P. J. Biol. Chem. (1998) [Pubmed]
  13. Micro-RNA-like effects of complete intronic sequences. Hill, A.E., Hong, J.S., Wen, H., Teng, L., McPherson, D.T., McPherson, S.A., Levasseur, D.N., Sorscher, E.J. Front. Biosci. (2006) [Pubmed]
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