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Gene Review

FOXD3  -  forkhead box D3

Homo sapiens

Synonyms: AIS1, Forkhead box protein D3, Genesis, HFH2, HNF3/FH transcription factor genesis, ...
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Disease relevance of FOXD3


Psychiatry related information on FOXD3


High impact information on FOXD3

  • Letter: Genesis of Dandy-Walker syndrome [7].
  • The POU homeodomain protein Oct-4 and the Forkhead Box protein FoxD3 (previously Genesis) are transcriptional regulators expressed in embryonic stem cells [8].
  • Visual cortex development in the ferret. I. Genesis and migration of visual cortical neurons [9].
  • We undertook a co-expression search using the Genesis Enterprise System Database from Gene Logic to identify prostasin inhibitors, on the assumption that prostasin and its natural inhibitors may have a similar gene expression pattern [10].
  • The 96-well format assay (512 hairpins) can be conducted at a minimal cost (presently ca. $100 for hairpin deoxyoligonucleotides/assay with ethiduim bromide or less with thiazole orange), with a rapid readout using a fluorescent plate reader (15 min), and is adaptable to automation (Tecan Genesis Workstation 100 robotic system) [11].

Biological context of FOXD3


Anatomical context of FOXD3


Associations of FOXD3 with chemical compounds

  • C1 complex of human complement. Genesis of a model [20].
  • Furthermore, each DNA contact sequence of Genesis showed distinct dynamic perturbation after Genesis binds to DNA [21].
  • Self-Assembly of Polystyrene-block-Poly(Ethylene Oxide) Copolymers at the Air-Water Interface: Is Dewetting the Genesis of Surface Aggregate Formation [22]?
  • The results presented in this technical note show that the TECAN Genesis robotic workstation can be utilized to automate cellular transport studies for evaluating excipient effects on P-glycoprotein activity in vitro and for estimating the permeation of drug-like molecules across cell monolayers [23].
  • A PC-operated SCADA (Supervisory Control And Data Acquisition) software (Genesis 4.20) is applied for temperature control using three advanced control loops [24].

Other interactions of FOXD3

  • In this study, amino acid substitutions were introduced into wing 1 of a conserved HNF-3 homologous protein, Genesis, and heteronuclear NMR, circular dichroism, DNA gel-shift assay, and fluorescent methods were employed to study and compare the properties of both wild-type and variant Genesis proteins [25].
  • PURPOSE: A prospective, multicenter, clinical study to evaluate a standardized surgical (Genesis) protocol which includes combined-technique radial incisions in patients seeking reduction of their physiologic myopia [26].
  • Jelenko O, Cameo, Jelstar and Genesis II alloys were compared unfired and fired to simulate porcelain application [27].

Analytical, diagnostic and therapeutic context of FOXD3

  • Stainless steel stents (Corinthian, Genesis, and Herculink) were placed in 38 arteries (34 patients) [28].
  • CONCLUSION: The combined-technique of radial keratotomy, coupled with the Genesis surgical protocol, affords centrifugal incision safety with centripetal incision efficacy [26].
  • The combined (Genesis) technique of radial keratotomy. A prospective, multicenter study. Refractive Keratoplasty Study Group [26].
  • The Genesis II prosthesis with a deep-dish tibial insert was used for all the patients [29].
  • We report a case of acute failure of a Genesis total knee arthroplasty (Smith and Nephew Orthopaedics, Memphis, TN) resulting from fracture of the eminence of the polyethylene posterior-stabilized tibial insert implanted in a revision procedure [30].


  1. Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Regulate Interleukin-8 Expression in Third Trimester Decidual Cells: Implications for the Genesis of Chorioamnionitis. Lockwood, C.J., Arcuri, F., Toti, P., Felice, C.D., Krikun, G., Guller, S., Buchwalder, L.F., Schatz, F. Am. J. Pathol. (2006) [Pubmed]
  2. The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism. McCartney, C.R., Prendergast, K.A., Chhabra, S., Eagleson, C.A., Yoo, R., Chang, R.J., Foster, C.M., Marshall, J.C. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  3. Evaluation of an automated liquid-handling system (Tecan Genesis RSP 100) in the Abbott LCx assay for Chlamydia trachomatis. Hanson, K.L., Cartwright, C.P. J. Clin. Microbiol. (2001) [Pubmed]
  4. Crimping and repositioning of a maldeployed balloon-expandable arterial stent using a gooseneck snare. Portugaller, H.R., Pabst, E., Doerfler, O.C., Tauss, J., Zangrando, M., Pilger, E., Klein, G.E. J. Endovasc. Ther. (2005) [Pubmed]
  5. p53 gene mutations in pituitary adenomas: rare events. Levy, A., Hall, L., Yeudall, W.A., Lightman, S.L. Clin. Endocrinol. (Oxf) (1994) [Pubmed]
  6. Project Genesis: assessing the efficacy of problem-solving therapy for distressed adult cancer patients. Nezu, A.M., Nezu, C.M., Felgoise, S.H., McClure, K.S., Houts, P.S. Journal of consulting and clinical psychology. (2003) [Pubmed]
  7. Letter: Genesis of Dandy-Walker syndrome. Smith, M.T., Huntington, H.W. N. Engl. J. Med. (1976) [Pubmed]
  8. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Guo, Y., Costa, R., Ramsey, H., Starnes, T., Vance, G., Robertson, K., Kelley, M., Reinbold, R., Scholer, H., Hromas, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Visual cortex development in the ferret. I. Genesis and migration of visual cortical neurons. Jackson, C.A., Peduzzi, J.D., Hickey, T.L. J. Neurosci. (1989) [Pubmed]
  10. Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. Fan, B., Wu, T.D., Li, W., Kirchhofer, D. J. Biol. Chem. (2005) [Pubmed]
  11. A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity. Boger, D.L., Fink, B.E., Brunette, S.R., Tse, W.C., Hedrick, M.P. J. Am. Chem. Soc. (2001) [Pubmed]
  12. Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo. Alkhateeb, A., Fain, P.R., Spritz, R.A. J. Invest. Dermatol. (2005) [Pubmed]
  13. Different DNA contact schemes are used by two winged helix proteins to recognize a DNA binding sequence. Bravieri, R., Shiyanova, T., Chen, T.H., Overdier, D., Liao, X. Nucleic Acids Res. (1997) [Pubmed]
  14. Different patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy: the Genesis France-Belgium Study. Hadjadj, S., Péan, F., Gallois, Y., Passa, P., Aubert, R., Weekers, L., Rigalleau, V., Bauduceau, B., Bekherraz, A., Roussel, R., Dussol, B., Rodier, M., Marechaud, R., Lefebvre, P.J., Marre, M. Diabetes Care (2004) [Pubmed]
  15. Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Ogura, K., Choudhuri, S., Klaassen, C.D. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  16. Microemboli during coronary artery bypass grafting. Genesis and effect on outcome. Clark, R.E., Brillman, J., Davis, D.A., Lovell, M.R., Price, T.R., Magovern, G.J. J. Thorac. Cardiovasc. Surg. (1995) [Pubmed]
  17. Low-profile stent system for treatment of atherosclerotic renal artery stenosis: the GREAT trial. Sapoval, M., Zähringer, M., Pattynama, P., Rabbia, C., Vignali, C., Maleux, G., Boyer, L., Szczerbo-Trojanowska, M., Jaschke, W., Hafsahl, G., Downes, M., Beregi, J.P., Veeger, N., Talen, A. Journal of vascular and interventional radiology : JVIR. (2005) [Pubmed]
  18. Posterior cruciate ligament at total knee replacement. Essential, beneficial or a hindrance? Straw, R., Kulkarni, S., Attfield, S., Wilton, T.J. The Journal of bone and joint surgery. British volume. (2003) [Pubmed]
  19. Revision of the patella with deficient bone using a biconvex component. Maheshwer, C.B., Mitchell, E., Kraay, M., Goldberg, V.M. Clin. Orthop. Relat. Res. (2005) [Pubmed]
  20. C1 complex of human complement. Genesis of a model. Colomb, M., Arlaud, G. J. Mol. Biol. (1987) [Pubmed]
  21. Backbone dynamics of a winged helix protein and its DNA complex at different temperatures: changes of internal motions in genesis upon binding to DNA. Jin, C., Liao, X. J. Mol. Biol. (1999) [Pubmed]
  22. Self-Assembly of Polystyrene-block-Poly(Ethylene Oxide) Copolymers at the Air-Water Interface: Is Dewetting the Genesis of Surface Aggregate Formation? Cheyne, R.B., Moffitt, M.G. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  23. Automated analysis of polyethylene glycol-induced inhibition of P-glycoprotein activity in vitro. Hugger, E.D., Cole, C.J., Raub, T.J., Burton, P.S., Borchardt, R.T. Journal of pharmaceutical sciences. (2003) [Pubmed]
  24. A sandwich-designed temperature-gradient incubator for studies of microbial temperature responses. Elsgaard, L., Jørgensen, L.W. J. Microbiol. Methods (2002) [Pubmed]
  25. Amino acid substitutions in a long flexible sequence influence thermodynamics and internal dynamic properties of winged helix protein genesis and its DNA complex. Yan, H., Liao, X. Biophys. J. (2003) [Pubmed]
  26. The combined (Genesis) technique of radial keratotomy. A prospective, multicenter study. Refractive Keratoplasty Study Group. Verity, S.M., Talamo, J.H., Chayet, A., Wolf, T.C., Rapoza, P., Schanzlin, D.J., Lane, S., Kenyon, K., Assil, K.K. Ophthalmology (1995) [Pubmed]
  27. Effects of the porcelain firing sequence on the bond strengths of cements. Kanoy, B.E., Felton, D.A., White, J.T., Bayne, C. Journal of oral rehabilitation. (1989) [Pubmed]
  28. Restenosis in gold-coated renal artery stents. Nolan, B.W., Schermerhorn, M.L., Powell, R.J., Rowell, E., Fillinger, M.F., Rzucidlo, E.M., Wyers, M.C., Whittaker, D., Zwolak, R.M., Walsh, D.B., Cronenwett, J.L. J. Vasc. Surg. (2005) [Pubmed]
  29. Lateral release rates after total knee arthroplasty. Laskin, R.S. Clin. Orthop. Relat. Res. (2001) [Pubmed]
  30. Fracture of posterior-stablized tibial insert in a Genesis knee prosthesis. Mariconda, M., Lotti, G., Milano, C. The Journal of arthroplasty. (2000) [Pubmed]
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