Disease relevance of FOXD3

• Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Regulate Interleukin-8 Expression in Third Trimester Decidual Cells: Implications for the Genesis of Chorioamnionitis [1].
• The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism [2].
• Evaluation of an automated liquid-handling system (Tecan Genesis RSP 100) in the Abbott LCx assay for Chlamydia trachomatis [3].
• CASE REPORT: A 58-year-old man was undergoing treatment for a significant right CIA stenosis when a 7x24-mm Palmaz Genesis medium stent was mistakenly deployed in the infrarenal aorta [4].
• DNA from small-scale plasmid preparations of pCR2 containing cloned p53 exons from human pituitary adenomas was sequenced using an automated fluorescence-based system (DuPont Genesis 2000) and compared with wild-type sequence [5].

Psychiatry related information on FOXD3

• Project Genesis: assessing the efficacy of problem-solving therapy for distressed adult cancer patients [6].

High impact information on FOXD3

• Letter: Genesis of Dandy-Walker syndrome [7].
• The POU homeodomain protein Oct-4 and the Forkhead Box protein FoxD3 (previously Genesis) are transcriptional regulators expressed in embryonic stem cells [8].
• Visual cortex development in the ferret. I. Genesis and migration of visual cortical neurons [9].
• We undertook a co-expression search using the Genesis Enterprise System Database from Gene Logic to identify prostasin inhibitors, on the assumption that prostasin and its natural inhibitors may have a similar gene expression pattern [10].
• The 96-well format assay (512 hairpins) can be conducted at a minimal cost (presently ca. $100 for hairpin deoxyoligonucleotides/assay with ethiduim bromide or less with thiazole orange), with a rapid readout using a fluorescent plate reader (15 min), and is adaptable to automation (Tecan Genesis Workstation 100 robotic system) [11].

Biological context of FOXD3

• Candidate functional promoter variant in the FOXD3 melanoblast developmental regulator gene in autosomal dominant vitiligo [12].
• In this report we present studies on the DNA binding properties of winged-helix HNF-3/fkh homologues 1 (HFH-1) and 2 (HFH-2) which recognize a shared DNA binding site with different affinities [13].
• Different patterns of response from HFH-1 and HFH-2 to both prebent and base-pair reverted binding sites was observed [13].
• HFH-1 and HFH-2 were shown to recognize DNA sites prebent at many nucleotide positions on both strands of the DNA sequence [13].
• Different patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy: the Genesis France-Belgium Study [14].

Anatomical context of FOXD3

• The 5'-flanking region of the gene contains consensus CAAT and TATA boxes and several potential binding sites for transcription factors for CAAT enhancer binding protein (C/EBP) and hepatocyte nuclear factors (HNF-3beta, HFH-1, and HFH-2), transcription factors important for liver-specific gene expression [15].
• Microemboli during coronary artery bypass grafting. Genesis and effect on outcome [16].
• CONCLUSIONS: The Palmaz Genesis stent (Cordis) provides good results for renal artery stent placement, with an in-stent binary restenosis rate (percent diameter stenosis > 50%) at 6 months of 14.3% as determined with angiography [17].
• We report the results of a prospective randomised trial which assessed the role of the posterior cruciate ligament (PCL) following total knee replacement (Genesis I; Smith and Nephew, Memphis, Tennessee) [18].
• We reviewed 20 knees in 20 patients in whom the residual patellar bone was less than 10 mm at the time of revision and used the Genesis Biconvex Patella implant to reconstruct the patella [19].

Associations of FOXD3 with chemical compounds

• C1 complex of human complement. Genesis of a model [20].
• Furthermore, each DNA contact sequence of Genesis showed distinct dynamic perturbation after Genesis binds to DNA [21].
• Self-Assembly of Polystyrene-block-Poly(Ethylene Oxide) Copolymers at the Air-Water Interface: Is Dewetting the Genesis of Surface Aggregate Formation [22]?
• The results presented in this technical note show that the TECAN Genesis robotic workstation can be utilized to automate cellular transport studies for evaluating excipient effects on P-glycoprotein activity in vitro and for estimating the permeation of drug-like molecules across cell monolayers [23].
• A PC-operated SCADA (Supervisory Control And Data Acquisition) software (Genesis 4.20) is applied for temperature control using three advanced control loops [24].

Other interactions of FOXD3

• In this study, amino acid substitutions were introduced into wing 1 of a conserved HNF-3 homologous protein, Genesis, and heteronuclear NMR, circular dichroism, DNA gel-shift assay, and fluorescent methods were employed to study and compare the properties of both wild-type and variant Genesis proteins [25].
• PURPOSE: A prospective, multicenter, clinical study to evaluate a standardized surgical (Genesis) protocol which includes combined-technique radial incisions in patients seeking reduction of their physiologic myopia [26].
• Jelenko O, Cameo, Jelstar and Genesis II alloys were compared unfired and fired to simulate porcelain application [27].

Analytical, diagnostic and therapeutic context of FOXD3

• Stainless steel stents (Corinthian, Genesis, and Herculink) were placed in 38 arteries (34 patients) [28].
• CONCLUSION: The combined-technique of radial keratotomy, coupled with the Genesis surgical protocol, affords centrifugal incision safety with centripetal incision efficacy [26].
• The combined (Genesis) technique of radial keratotomy. A prospective, multicenter study. Refractive Keratoplasty Study Group [26].
• The Genesis II prosthesis with a deep-dish tibial insert was used for all the patients [29].
• We report a case of acute failure of a Genesis total knee arthroplasty (Smith and Nephew Orthopaedics, Memphis, TN) resulting from fracture of the eminence of the polyethylene posterior-stabilized tibial insert implanted in a revision procedure [30].

References