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Gene Review:

opgG - OPG biosynthetic periplasmic beta-1,6...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1034, JW1035, mdoA, mdoG

Lacroix, J.M. et al., Lacroix, J.M. et al., Loubens, I. et al., Höltje, J.V. et al., Lequette, Y. et al., et al.

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Disease relevance of mdoG

Orthologs of the mdoG and mdoD genes are found in various proteobacteria [1].
Mutants of Escherichia coli defective in the mdoA locus are blocked at an early stage in the biosynthesis of membrane-derived oligosaccharides [2].

High impact information on mdoG

Their phenotype was compared with a mdoA mutant previously identified, and they are mapped in the mdoA region [3].
The lysis gene product normally found in the membrane fraction was not stably inserted into the membranes of a mdoA mutant; rather degradation and release from the membrane occurred [4].
Homology between a genetic locus (mdoA) involved in the osmoregulated biosynthesis of periplasmic glucans in Escherichia coli and a genetic locus (hrpM) controlling pathogenicity of Pseudomonas syringae [5].
In Escherichia coli, the 5 kb mdoA locus is involved in the osmotically controlled biosynthesis of periplasmic membrane-derived oligosaccharides (MDOs) [6].
A 'neo' cassette, derived from the neomycin phosphotransferase II region of transposon Tn5, was inserted into mdoA, borne by a multicopy plasmid [6].

Biological context of mdoG

This plasmid was shown to complement two previously described mdoA mutations, depending on the orientation of the exogenous gene [6].
The mdoA locus of Escherichia coli consists of an operon under osmotic control [6].

Other interactions of mdoG

The new gene mdoD, which appears to be a paralog of mdoG, was characterized in this study [1].

Analytical, diagnostic and therapeutic context of mdoG

Molecular cloning and expression of a locus (mdoA) implicated in the biosynthesis of membrane-derived oligosaccharides in Escherichia coli [2].

References

Identification of mdoD, an mdoG paralog which encodes a twin-arginine-dependent periplasmic protein that controls osmoregulated periplasmic glucan backbone structures. Lequette, Y., Odberg-Ferragut, C., Bohin, J.P., Lacroix, J.M. J. Bacteriol. (2004) [Pubmed]
Molecular cloning and expression of a locus (mdoA) implicated in the biosynthesis of membrane-derived oligosaccharides in Escherichia coli. Lacroix, J.M., Tempête, M., Menichi, B., Bohin, J.P. Mol. Microbiol. (1989) [Pubmed]
Properties of Escherichia coli mutants lacking membrane-derived oligosaccharides. Fiedler, W., Rotering, H. J. Biol. Chem. (1988) [Pubmed]
Lysis induction of Escherichia coli by the cloned lysis protein of the phage MS2 depends on the presence of osmoregulatory membrane-derived oligosaccharides. Höltje, J.V., Fiedler, W., Rotering, H., Walderich, B., van Duin, J. J. Biol. Chem. (1988) [Pubmed]
Homology between a genetic locus (mdoA) involved in the osmoregulated biosynthesis of periplasmic glucans in Escherichia coli and a genetic locus (hrpM) controlling pathogenicity of Pseudomonas syringae. Loubens, I., Debarbieux, L., Bohin, A., Lacroix, J.M., Bohin, J.P. Mol. Microbiol. (1993) [Pubmed]
The mdoA locus of Escherichia coli consists of an operon under osmotic control. Lacroix, J.M., Loubens, I., Tempête, M., Menichi, B., Bohin, J.P. Mol. Microbiol. (1991) [Pubmed]

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