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Gene Review

proC  -  pyrroline-5-carboxylate reductase, NAD(P)...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0381, JW0377, Pro2, pro
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Disease relevance of proC


High impact information on proC


Biological context of proC


Associations of proC with chemical compounds

  • Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+) [6].

Other interactions of proC


Analytical, diagnostic and therapeutic context of proC

  • Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase [6].


  1. Escherichia coli delta 1-pyrroline-5-carboxylate reductase: gene sequence, protein overproduction and purification. Deutch, A.H., Smith, C.J., Rushlow, K.E., Kretschmer, P.J. Nucleic Acids Res. (1982) [Pubmed]
  2. Complementation of an Escherichia coli proC mutation by a gene cloned from Treponema pallidum. Gherardini, F.C., Hobbs, M.M., Stamm, L.V., Bassford, P.J. J. Bacteriol. (1990) [Pubmed]
  3. Pseudomonas aeruginosa promoters which contain a conserved GG-N10-GC motif but appear to be RpoN-independent. Savioz, A., Zimmermann, A., Haas, D. Mol. Gen. Genet. (1993) [Pubmed]
  4. Development of a markerless genetic exchange method for Methanosarcina acetivorans C2A and its use in construction of new genetic tools for methanogenic archaea. Pritchett, M.A., Zhang, J.K., Metcalf, W.W. Appl. Environ. Microbiol. (2004) [Pubmed]
  5. Nucleotide sequence of the alkaline phosphatase gene of Escherichia coli. Chang, C.N., Kuang, W.J., Chen, E.Y. Gene (1986) [Pubmed]
  6. Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase. Meng, Z., Lou, Z., Liu, Z., Hui, D., Bartlam, M., Rao, Z. Protein Expr. Purif. (2006) [Pubmed]
  7. Genetic and physical characterization of proBA genes of the marine bacterium Vibrio parahaemolyticus. Datta, A.R., Ostroff, R., MacQuillan, A.M. Appl. Environ. Microbiol. (1987) [Pubmed]
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