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Gene Review

nth  -  DNA glycosylase and apyrimidinic (AP)...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1629, JW1625
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Disease relevance of nth


High impact information on nth

  • Mutants of Escherichia coli and mice (ref. 4 and M. Takao et al., personal communication) that are deficient in DNA glycosylases that remove oxidized bases are not sensitive to reactive oxygen species, and the E. coli triple mutant nei, nth, fpg is more radioresistant than the wild-type strain [2].
  • The fpg gene is different from the xth, nth, and nfo genes of E. coli, whose gene products also cleave DNA at AP sites [3].
  • Inspection of the nucleotide sequence reveals that there is an open reading frame immediately upstream of the nth gene, suggesting that it might be part of an operon [4].
  • A strong chronic induction of the SOS response system occurs in E. coli BW535, a strain defective in nth, nfo and xth genes, and hence severely deficient in the repair of abasic sites in DNA [5].
  • A triple mutant strain (nth nfo xthA) exhibited the greatest sensitivity to near-UV-mediated lethality [6].

Biological context of nth


Other interactions of nth


  1. Genetic mapping of nth, a gene affecting endonuclease III (thymine glycol-DNA glycosylase) in Escherichia coli K-12. Weiss, B., Cunningham, R.P. J. Bacteriol. (1985) [Pubmed]
  2. Alternative nucleotide incision repair pathway for oxidative DNA damage. Ischenko, A.A., Saparbaev, M.K. Nature (2002) [Pubmed]
  3. Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. O'Connor, T.R., Laval, J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene. Asahara, H., Wistort, P.M., Bank, J.F., Bakerian, R.H., Cunningham, R.P. Biochemistry (1989) [Pubmed]
  5. E. coli BW535, a triple mutant for the DNA repair genes xth, nth, and nfo, chronically induces the SOS response. Janion, C., Sikora, A., Nowosielska, A., Grzesiuk, E. Environ. Mol. Mutagen. (2003) [Pubmed]
  6. Endonuclease III and endonuclease IV protect Escherichia coli from the lethal and mutagenic effects of near-UV irradiation. Serafini, D.M., Schellhorn, H.E. Can. J. Microbiol. (1999) [Pubmed]
  7. The genes encoding endonuclease VIII and endonuclease III in Escherichia coli are transcribed as the terminal genes in operons. Gifford, C.M., Wallace, S.S. Nucleic Acids Res. (2000) [Pubmed]
  8. Identification of repair enzymes for 5-formyluracil in DNA. Nth, Nei, and MutM proteins of Escherichia coli. Zhang, Q.M., Miyabe, I., Matsumoto, Y., Kino, K., Sugiyama, H., Yonei, S. J. Biol. Chem. (2000) [Pubmed]
  9. Thi1, a thiamine biosynthetic gene in Arabidopsis thaliana, complements bacterial defects in DNA repair. Machado, C.R., de Oliveira, R.L., Boiteux, S., Praekelt, U.M., Meacock, P.A., Menck, C.F. Plant Mol. Biol. (1996) [Pubmed]
  10. Escherichia coli endonuclease VIII: cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutants. Jiang, D., Hatahet, Z., Blaisdell, J.O., Melamede, R.J., Wallace, S.S. J. Bacteriol. (1997) [Pubmed]
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