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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Communication


High impact information on Communication

  • Genes related to Cdt1 have been found in Metazoa and plants (A. Whitaker, I. Roysman and T. Orr-Weaver, personal communication), suggesting that the cooperation of Cdc6/Cdc18 with Cdt1 to load MCM proteins onto chromatin may be a generally conserved feature of DNA licensing in eukaryotes [6].
  • The polypeptides are synthesized as an additional 52 or 76-80 amino acids on the C terminus of ubiquitin, an unusual arrangement conserved in man, yeast and plants (J. Callis and R. Vierstra, personal communication) [7].
  • But several recent experiments on aspartate aminotransferase, trypsin and aspartate transcarbamoylase (Schachman, H. K. personal communication) have indicated that polarity reversal is not so successful [8].
  • However, some eukaryotes, such as Drosophila and yeast (S. Hattman, personal communication) seem not to contain 5-methylcytosine in their DNA [9].
  • For example, the pkA inhibitor protein (pkI) is 80-90% inactivated when tyrosine-phosphorylated by the EGF receptor or pp50v-src (D. Walsh, personal communication) [10].

Biological context of Communication


Anatomical context of Communication

  • In conjunction with the recent hypothesis that p40 constitutes a translation initiation factor (D. Auth and G. Brawerman, personal communication), these observations point to a dorso-ventral asymmetry in some aspect of protein translation, which in turn may set up differences in recognition factors on retinal growth cones [16].
  • In contrast, antibody raised against carnitine palmitoyltransferase purified from liver mitochondrial membranes had no effect (P. Brady & L. Brady, personal communication) [17].
  • The BGN (Berufsgenossenschaft Nahrungsmithl und Gaststätten) reports 70% of job induced days off work to be connected with traumas of the ankle joint or overloading of the leg, knee and lower back, with an increased incidence in service areas outdoors (R. Grieshaber, personal communication) [18].

Associations of Communication with chemical compounds

  • Misinformation about deferiprone (L1) [19].
  • Amino acid composition and the results of limited sequential degradation showed that this peptide corresponds to residues 62 to 98 in the sequence of Konigsberg and co-workers, and contains 2 residues of lysine (Henderson, L., Roy, D., Martin, D., and Konigsberg, W., personal communication) [20].
  • The antigenic source in PPD for these cells has not yet been determined, but as for the mouse, a low molecular weight peptide appears to be sufficient for stimulation (P. Brennan and R. Modlin, personal communication) [21].
  • However, despite significant efforts to educate the public and the health care industry regarding latex allergies, considerable misinformation persists [22].
  • It could clearly be shown that the cross-link site was contained within a characteristic peptide 16--20 amino acids long and that the amino acid concerned was the tyrosine residue at position 35 in the recently completed L4 sequence (M. Kimura and B. Wittmann-Liebold, personal communication) [23].

Gene context of Communication


Analytical, diagnostic and therapeutic context of Communication

  • The authors cite various information and misinformation regarding proposed treatments (atropinization, contact lenses, orthokeratology, wearing glasses, not wearing glasses) for the progression of myopia [29].


  1. Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine. Gilmore, T., Martin, G.S. Nature (1983) [Pubmed]
  2. Cost-effectiveness of irbesartan in diabetic nephropathy: a systematic review of published studies. Palmer, A.J., Tucker, D.M., Valentine, W.J., Roze, S., Gabriel, S., Cordonnier, D.J. Nephrol. Dial. Transplant. (2005) [Pubmed]
  3. Detection of viruses by electron microscopy: an efficient approach. MacRae, J., Srivastava, M. J. Virol. Methods (1998) [Pubmed]
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  6. The Cdt1 protein is required to license DNA for replication in fission yeast. Nishitani, H., Lygerou, Z., Nishimoto, T., Nurse, P. Nature (2000) [Pubmed]
  7. Identification of the long ubiquitin extension as ribosomal protein S27a. Redman, K.L., Rechsteiner, M. Nature (1989) [Pubmed]
  8. Why ion pair reversal by protein engineering is unlikely to succeed. Hwang, J.K., Warshel, A. Nature (1988) [Pubmed]
  9. Expression of a bacterial modification methylase gene in yeast. Fehér, Z., Kiss, A., Venetianer, P. Nature (1983) [Pubmed]
  10. The hormone-induced regulation of contact-dependent cell-cell communication by phosphorylation. Stagg, R.B., Fletcher, W.H. Endocr. Rev. (1990) [Pubmed]
  11. Properties and functions of Escherichia coli: Pol IV and Pol V. Fuchs, R.P., Fujii, S., Wagner, J. Adv. Protein Chem. (2004) [Pubmed]
  12. Processing and amino acid sequence analysis of the mouse mammary tumor virus env gene product. Arthur, L.O., Copeland, T.D., Oroszlan, S., Schochetman, G. J. Virol. (1982) [Pubmed]
  13. Enzyme-catalyzed dehalogenation of pentachloroethane: why F87W-cytochrome P450cam is faster than wild type. Manchester, J.I., Ornstein, R.L. Protein Eng. (1995) [Pubmed]
  14. Primary structure of a ribonuclease from bullfrog (Rana catesbeiana) liver. Nitta, R., Katayama, N., Okabe, Y., Iwama, M., Watanabe, H., Abe, Y., Okazaki, T., Ohgi, K., Irie, M. J. Biochem. (1989) [Pubmed]
  15. Interferon-alpha and its effects on post-transplant lymphoproliferative disorders. Faro, A. Springer Semin. Immunopathol. (1998) [Pubmed]
  16. A dorso-ventral asymmetry in the embryonic retina defined by protein conformation. McCaffery, P., Neve, R.L., Dräger, U.C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  17. Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase? Healy, M.J., Kerner, J., Bieber, L.L. Biochem. J. (1988) [Pubmed]
  18. Modulation of mechanical and muscular load by footwear during catering. Kersting, U.G., Janshen, L., Böhm, H., Morey-Klapsing, G.M., Brüggemann, G.P. Ergonomics. (2005) [Pubmed]
  19. Misinformation about deferiprone (L1). Kontoghiorghes, G.J. Lancet (1993) [Pubmed]
  20. Pyridoxal 5'-phosphate, a fluorescent probe in the active site of aspartate transcarbamylase. Kempe, T.D., Stark, G.R. J. Biol. Chem. (1975) [Pubmed]
  21. Recognition of a single hsp-60 epitope by an entire subset of gamma delta T lymphocytes. O'Brien, R.L., Happ, M.P., Dallas, A., Cranfill, R., Hall, L., Lang, J., Fu, Y.X., Kubo, R., Born, W. Immunol. Rev. (1991) [Pubmed]
  22. Latex allergy: the perspective from the surgical suite. Elliott, B.A. J. Allergy Clin. Immunol. (2002) [Pubmed]
  23. Precise localization of the site of cross-linking between protein L4 and 23S ribonucleic acid induced by mild ultraviolet irradiation of Escherichia coli 50S ribosomal subunits. Maly, P., Rinke, J., Ulmer, E., Zwieb, C., Brimacombe, R. Biochemistry (1980) [Pubmed]
  24. Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. Singer-Krüger, B., Stenmark, H., Düsterhöft, A., Philippsen, P., Yoo, J.S., Gallwitz, D., Zerial, M. J. Cell Biol. (1994) [Pubmed]
  25. The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Eberharter, A., Sterner, D.E., Schieltz, D., Hassan, A., Yates, J.R., Berger, S.L., Workman, J.L. Mol. Cell. Biol. (1999) [Pubmed]
  26. Proliferating cell nuclear antigen (pol30) mutations suppress cdc44 mutations and identify potential regions of interaction between the two encoded proteins. McAlear, M.A., Howell, E.A., Espenshade, K.K., Holm, C. Mol. Cell. Biol. (1994) [Pubmed]
  27. The CDC8 gene of yeast encodes thymidylate kinase. Jong, A.Y., Kuo, C.L., Campbell, J.L. J. Biol. Chem. (1984) [Pubmed]
  28. The VPH2 gene encodes a 25 kDa protein required for activity of the yeast vacuolar H(+)-ATPase. Bachhawat, A.K., Manolson, M.F., Murdock, D.G., Garman, J.D., Jones, E.W. Yeast (1993) [Pubmed]
  29. Myopia--a treatable "disease"? Rubin, M.L., Milder, B. Survey of ophthalmology. (1976) [Pubmed]
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