Gene Review:
xthA - exonuclease III
Escherichia coli str. K-12 substr. MG1655
Synonyms:
ECK1747, JW1738, xth
- Genetic mapping of xthA, the structural gene for exonuclease III in Escherichia coli K-12. White, B.J., Hochhauser, S.J., Cintron, N.M., Weiss, B. J. Bacteriol. (1976)
- A mutant endonuclease IV of Escherichia coli loses the ability to repair lethal DNA damage induced by hydrogen peroxide but not that induced by methyl methanesulfonate. Izumi, T., Ishizaki, K., Ikenaga, M., Yonei, S. J. Bacteriol. (1992)
- W-reactivation and W-mutagenesis of gamma-irradiated phage lambda. Bresler, S.E., Kalinin, V.L., Shelegedin, V.N. Mutat. Res. (1978)
- Alpha-deoxyadenosine, a major anoxic radiolysis product of adenine in DNA, is a substrate for Escherichia coli endonuclease IV. Ide, H., Tedzuka, K., Shimzu, H., Kimura, Y., Purmal, A.A., Wallace, S.S., Kow, Y.W. Biochemistry (1994)
- Development of T7 phage and T7 phage containing apurinic sites in an exonuclease III, endonuclease IV double mutant of Escherichia coli. Sanchez, G., Mamet-Bratley, M.D. Biochem. Cell Biol. (1992)
- Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol, C.D., Kuo, C.F., Thayer, M.M., Cunningham, R.P., Tainer, J.A. Nature (1995)
- An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5' cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site. Hang, B., Chenna, A., Fraenkel-Conrat, H., Singer, B. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Exonuclease III recognizes urea residues in oxidized DNA. Kow, Y.W., Wallace, S.S. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Construction of a general vector for efficient expression of mammalian proteins in bacteria: use of a synthetic ribosome binding site. Jay, G., Khoury, G., Seth, A.K., Jay, E. Proc. Natl. Acad. Sci. U.S.A. (1981)
- The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis. Bennett, R.A. Mol. Cell. Biol. (1999)
- Role of exonuclease III and endonuclease IV in repair of pyrimidine dimers initiated by bacteriophage T4 pyrimidine dimer-DNA glycosylase. Saporito, S.M., Gedenk, M., Cunningham, R.P. J. Bacteriol. (1989)
- Repair of DNA lesions induced by hydrogen peroxide in the presence of iron chelators in Escherichia coli: participation of endonuclease IV and Fpg. Galhardo, R.S., Almeida, C.E., Leitão, A.C., Cabral-Neto, J.B. J. Bacteriol. (2000)
- Nitroxides block DNA scission and protect cells from oxidative damage. Samuni, A., Godinger, D., Aronovitch, J., Russo, A., Mitchell, J.B. Biochemistry (1991)
- Escherichia coli xthA mutant is not hypersensitive to ascorbic acid/copper treatment--an H2O2 generating reaction. Van Sluys, M.A., Alcantara-Gomes, R., Menck, C.F. Mutat. Res. (1986)
- In situ detection of AP sites and DNA strand breaks bearing 3'-phosphate termini in ischemic mouse brain. Huang, D., Shenoy, A., Cui, J., Huang, W., Liu, P.K. FASEB J. (2000)
- Isolation of catalase-deficient Escherichia coli mutants and genetic mapping of katE, a locus that affects catalase activity. Loewen, P.C. J. Bacteriol. (1984)
- Linear multimer formation of plasmid DNA in Escherichia coli hopE (recD) mutants. Niki, H., Ogura, T., Hiraga, S. Mol. Gen. Genet. (1990)
- Involvement of DNA lesions and SOS functions in 5-bromouracil-induced mutagenesis. Pietrzykowska, I., Krych, M., Shugar, D. Mutat. Res. (1985)
- Endonuclease IV and Exonuclease III are involved in the repair and mutagenesis of DNA lesions induced by UVB in Escherichia coli. Souza, L.L., Eduardo, I.R., Pádula, M., Leitão, A.C. Mutagenesis (2006)
- Opposing effects of nitroxide free radicals in Escherichia coli mutants deficient in DNA repair. Wang, G., Godinger, D., Aronovitch, J., Samuni, A. Biochim. Biophys. Acta (1996)
- Multiple pathways for repair of hydrogen peroxide-induced DNA damage in Escherichia coli. Hagensee, M.E., Moses, R.E. J. Bacteriol. (1989)
- Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases. Takeshita, M., Chang, C.N., Johnson, F., Will, S., Grollman, A.P. J. Biol. Chem. (1987)
- Adenovirus terminal protein protects single stranded DNA from digestion by a cellular exonuclease. Dunsworth-Browne, M., Schell, R.E., Berk, A.J. Nucleic Acids Res. (1980)
- Synthesis of dihydrothymidine and thymidine glycol 5'-triphosphates and their ability to serve as substrates for Escherichia coli DNA polymerase I. Ide, H., Melamede, R.J., Wallace, S.S. Biochemistry (1987)
- The expression of Exonuclease III from E. coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress. Shokolenko, I.N., Alexeyev, M.F., Robertson, F.M., LeDoux, S.P., Wilson, G.L. DNA Repair (Amst.) (2003)
- The cadmium-stress stimulon of Escherichia coli K-12. Ferianc, P., Farewell, A., Nyström, T. Microbiology (Reading, Engl.) (1998)
- Cleavage of single- and double-stranded DNAs containing an abasic residue by Escherichia coli exonuclease III (AP endonuclease VI). Shida, T., Noda, M., Sekiguchi, J. Nucleic Acids Res. (1996)
- Endonuclease IV (nfo) mutant of Escherichia coli. Cunningham, R.P., Saporito, S.M., Spitzer, S.G., Weiss, B. J. Bacteriol. (1986)
- Requirement of the Escherichia coli dnaK gene for thermotolerance and protection against H2O2. Delaney, J.M. J. Gen. Microbiol. (1990)
- Endonuclease III and endonuclease IV protect Escherichia coli from the lethal and mutagenic effects of near-UV irradiation. Serafini, D.M., Schellhorn, H.E. Can. J. Microbiol. (1999)
- Site-specific insertion of gene cassettes into integrons. Collis, C.M., Grammaticopoulos, G., Briton, J., Stokes, H.W., Hall, R.M. Mol. Microbiol. (1993)
- Characterization of a protein binding sequence in the promoter region of the 16S rRNA gene of the spinach chloroplast genome. Baeza, L., Bertrand, A., Mache, R., Lerbs-Mache, S. Nucleic Acids Res. (1991)
- Purification, crystallization and space group determination of DNA repair enzyme exonuclease III from E. coli. Kuo, C.F., McRee, D.E., Cunningham, R.P., Tainer, J.A. J. Mol. Biol. (1993)
- Infecting bacteriophage mu DNA forms a circular DNA-protein complex. Harshey, R.M., Bukhari, A.I. J. Mol. Biol. (1983)
- Synchronous digestion of SV40 DNA by exonuclease III. Wu, R., Ruben, G., Siegel, B., Jay, E., Spielman, P., Tu, C.P. Biochemistry (1976)