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Gene Review

rpsD  -  30S ribosomal subunit protein S4

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3283, JW3258, ramA, sud
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Disease relevance of rpsD

  • The leader region of rpsD mRNA is predicted to have extensive secondary structure, resembling a region of B. subtilis 16S rRNA where S4 is likely to bind; similar mRNA features have been found to be important in ribosomal gene regulation in E. coli [1].
  • The rpsD gene, encoding ribosomal protein S4, was isolated from Bacillus subtilis by hybridization with oligonucleotide probes derived from the S4 amino-terminal protein sequence [1].
  • Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium [2].
  • The amount of R-amidase in the supernatant of the sonicated cell-free extract of an Escherichia coli transformant overexpressing the ramA gene was about 30 000 times higher than that of Pseudomonas sp. MCI3434 [3].

High impact information on rpsD


Biological context of rpsD

  • These results provide the first steps toward analysis of the regulation of rpsD gene expression in B. subtilis [1].

Analytical, diagnostic and therapeutic context of rpsD


  1. Cloning and analysis of the Bacillus subtilis rpsD gene, encoding ribosomal protein S4. Grundy, F.J., Henkin, T.M. J. Bacteriol. (1990) [Pubmed]
  2. Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium. van der Straaten, T., Janssen, R., Mevius, D.J., van Dissel, J.T. Antimicrob. Agents Chemother. (2004) [Pubmed]
  3. A novel R-stereoselective amidase from Pseudomonas sp. MCI3434 acting on piperazine-2-tert-butylcarboxamide. Komeda, H., Harada, H., Washika, S., Sakamoto, T., Ueda, M., Asano, Y. Eur. J. Biochem. (2004) [Pubmed]
  4. Characterization of the Bacillus subtilis rpsD regulatory target site. Grundy, F.J., Henkin, T.M. J. Bacteriol. (1992) [Pubmed]
  5. The rpsD gene, encoding ribosomal protein S4, is autogenously regulated in Bacillus subtilis. Grundy, F.J., Henkin, T.M. J. Bacteriol. (1991) [Pubmed]
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