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Gene Review

tyrS  -  tyrosyl-tRNA synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1633, JW1629
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Disease relevance of tyrS


High impact information on tyrS


Chemical compound and disease context of tyrS


Biological context of tyrS


Associations of tyrS with chemical compounds

  • Expression of a transcriptional tyrS-lacZ fusion was found to be induced by starvation for tyrosine in a tyrosine auxotroph (tyrA1) [9].

Other interactions of tyrS


  1. The tyrosyl-tRNA synthetase from Escherichia coli. Complete nucleotide sequence of the structural gene. Barker, D.G., Bruton, C.J., Winter, G. FEBS Lett. (1982) [Pubmed]
  2. tRNA determinants for transcription antitermination of the Bacillus subtilis tyrS gene. Grundy, F.J., Collins, J.A., Rollins, S.M., Henkin, T.M. RNA (2000) [Pubmed]
  3. Overproduction of tyrosyl-tRNA synthetase is toxic to Escherichia coli: a genetic analysis. Bedouelle, H., Guez, V., Vidal-Cros, A., Hermann, M. J. Bacteriol. (1990) [Pubmed]
  4. A mutant Escherichia coli tyrosyl-tRNA synthetase utilizes the unnatural amino acid azatyrosine more efficiently than tyrosine. Hamano-Takaku, F., Iwama, T., Saito-Yano, S., Takaku, K., Monden, Y., Kitabatake, M., Soll, D., Nishimura, S. J. Biol. Chem. (2000) [Pubmed]
  5. Glutamyl-tRNA synthetase of Escherichia coli. Isolation and primary structure of the gltX gene and homology with other aminoacyl-tRNA synthetases. Breton, R., Sanfaçon, H., Papayannopoulos, I., Biemann, K., Lapointe, J. J. Biol. Chem. (1986) [Pubmed]
  6. Structural snapshots of the KMSKS loop rearrangement for amino acid activation by bacterial tyrosyl-tRNA synthetase. Kobayashi, T., Takimura, T., Sekine, R., Kelly, V.P., Vincent, K., Kamata, K., Sakamoto, K., Nishimura, S., Yokoyama, S. J. Mol. Biol. (2005) [Pubmed]
  7. Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations. Lam, H.M., Winkler, M.E. J. Bacteriol. (1992) [Pubmed]
  8. Cloning and analysis of the Bacillus subtilis rpsD gene, encoding ribosomal protein S4. Grundy, F.J., Henkin, T.M. J. Bacteriol. (1990) [Pubmed]
  9. Analysis of the Bacillus subtilis tyrS gene: conservation of a regulatory sequence in multiple tRNA synthetase genes. Henkin, T.M., Glass, B.L., Grundy, F.J. J. Bacteriol. (1992) [Pubmed]
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