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Gene Review:

CHST10 - carbohydrate sulfotransferase 10

Homo sapiens

Synonyms: Carbohydrate sulfotransferase 10, HNK-1 sulfotransferase, HNK-1ST, HNK1ST, HuHNK-1ST

Hiraoka, N. et al., Ong, E. et al., Ong, E. et al., Hiraoka, N. et al.

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High impact information on CHST10

During this cloning we found that HNK-1ST and other Golgi-associated sulfotransferases cloned before share homologous sequences including the RDP motif (Ong, E., Yeh, J.-C., Ding, Y., Hindsgaul, O., and Fukuda, M. (1998) J. Biol. Chem. 223, 5190-5195) [1].
Using this conserved sequence in HNK-1ST as a probe, we identified two expressed sequence tags in EST data base which have 31.6 and 30.7% identity with HNK-1ST at the amino acid levels [1].
HNK-1ST belongs to the sulfotransferase gene family, which shares two homologous sequences in their catalytic domains [2].
Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis [2].
The results combined together indicate that the cloned HNK-1ST directs the synthesis of the HNK-1 carbohydrate epitope on both glycoproteins and glycolipids in the nervous tissues [3].

Other interactions of CHST10

These newly cloned enzymes, termed GalNAc4ST-1 and GalNAc4ST-2, belong to the HNK-1ST gene family having 40--42% identity with C4ST-1 [4].

Analytical, diagnostic and therapeutic context of CHST10

Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family [1].

References

Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family. Hiraoka, N., Nakagawa, H., Ong, E., Akama, T.O., Fukuda, M.N., Fukuda, M. J. Biol. Chem. (2000) [Pubmed]
Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis. Ong, E., Yeh, J.C., Ding, Y., Hindsgaul, O., Pedersen, L.C., Negishi, M., Fukuda, M. J. Biol. Chem. (1999) [Pubmed]
Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids. Ong, E., Yeh, J.C., Ding, Y., Hindsgaul, O., Fukuda, M. J. Biol. Chem. (1998) [Pubmed]
Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1-->4GlcNAc beta 1-->R in both N- and O-glycans. Hiraoka, N., Misra, A., Belot, F., Hindsgaul, O., Fukuda, M. Glycobiology (2001) [Pubmed]

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