Disease relevance of fecR

• Regulation of citrate-dependent iron transport of Escherichia coli: fecR is required for transcription activation by FecI [1].
• Five fecI/fecR/iron receptor gene clusters from P. putida were also identified in the human pathogen Pseudomonas aeruginosa [2].

High impact information on fecR

• Two regulatory genes, fecI and fecR, located upstream of the fecABCDE transport genes, are required for induction [1].
• Inactivation of fecR results in significant increases in both cell aggregation and biofilm formation, while the effects of cspA are not as strong in the conditions tested [3].
• All FecR'-BlaM proteins with at least 61 FecR residues complemented a fecR mutant such that it could grow on ferric citrate as the sole iron source and induced fecA-lacZ transcription independent of ferric citrate [4].
• Growth was restored by transformation with plasmids encoding fecI or fecI and fecR [5].

Associations of fecR with chemical compounds

• Under iron-limiting conditions, Fur is not loaded with Fe2+, the fecI and fecR genes are transcribed, and the FecI and FecR proteins are synthesized and respond to the presence of ferric citrate in the medium when ferric citrate binds to the FecA protein [6].
• Under iron-limiting conditions, Fur is not loaded with Fe(2+), the fecI and fecR genes are transcribed, and the FecI and FecR proteins are synthesized and respond to the presence of ferric citrate in the medium when ferric citrate binds to the FecA protein [7].

Other interactions of fecR

• The fecI gene encodes a protein of 173 amino acids (molecular weight, 19,478); the fecR gene encodes a protein of 317 amino acids (molecular weight, 35,529) [5].
• FecR protein produced by fecR mutants impaired or constitutive in fecA transcription was protease resistant, indicating that conformational changes affect proper functioning of FecR [8].

References