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Gene Review

fecR  -  anti-sigma transmembrane signal transducer...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4282, JW4252
 
 
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Disease relevance of fecR

 

High impact information on fecR

  • Two regulatory genes, fecI and fecR, located upstream of the fecABCDE transport genes, are required for induction [1].
  • Inactivation of fecR results in significant increases in both cell aggregation and biofilm formation, while the effects of cspA are not as strong in the conditions tested [3].
  • All FecR'-BlaM proteins with at least 61 FecR residues complemented a fecR mutant such that it could grow on ferric citrate as the sole iron source and induced fecA-lacZ transcription independent of ferric citrate [4].
  • Growth was restored by transformation with plasmids encoding fecI or fecI and fecR [5].
 

Associations of fecR with chemical compounds

  • Under iron-limiting conditions, Fur is not loaded with Fe2+, the fecI and fecR genes are transcribed, and the FecI and FecR proteins are synthesized and respond to the presence of ferric citrate in the medium when ferric citrate binds to the FecA protein [6].
  • Under iron-limiting conditions, Fur is not loaded with Fe(2+), the fecI and fecR genes are transcribed, and the FecI and FecR proteins are synthesized and respond to the presence of ferric citrate in the medium when ferric citrate binds to the FecA protein [7].
 

Other interactions of fecR

  • The fecI gene encodes a protein of 173 amino acids (molecular weight, 19,478); the fecR gene encodes a protein of 317 amino acids (molecular weight, 35,529) [5].
  • FecR protein produced by fecR mutants impaired or constitutive in fecA transcription was protease resistant, indicating that conformational changes affect proper functioning of FecR [8].

References

  1. Regulation of citrate-dependent iron transport of Escherichia coli: fecR is required for transcription activation by FecI. Ochs, M., Veitinger, S., Kim, I., Welz, D., Angerer, A., Braun, V. Mol. Microbiol. (1995) [Pubmed]
  2. Detection of multiple extracytoplasmic function (ECF) sigma factors in the genome of Pseudomonas putida KT2440 and their counterparts in Pseudomonas aeruginosa PA01. Martínez-Bueno, M.A., Tobes, R., Rey, M., Ramos, J.L. Environ. Microbiol. (2002) [Pubmed]
  3. Gene expression regulation by the Curli activator CsgD protein: modulation of cellulose biosynthesis and control of negative determinants for microbial adhesion. Brombacher, E., Baratto, A., Dorel, C., Landini, P. J. Bacteriol. (2006) [Pubmed]
  4. Ferric citrate transport of Escherichia coli: functional regions of the FecR transmembrane regulatory protein. Welz, D., Braun, V. J. Bacteriol. (1998) [Pubmed]
  5. Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12. Van Hove, B., Staudenmaier, H., Braun, V. J. Bacteriol. (1990) [Pubmed]
  6. Gene regulation by transmembrane signaling. Braun, V., Mahren, S., Sauter, A. Biometals (2006) [Pubmed]
  7. Gene regulation by transmembrane signaling. Braun, V., Mahren, S., Sauter, A. Biometals (2005) [Pubmed]
  8. Transcriptional regulation from the cell surface: conformational changes in the transmembrane protein FecR lead to altered transcription of the ferric citrate transport genes in Escherichia coli. Wriedt, K., Angerer, A., Braun, V. J. Bacteriol. (1995) [Pubmed]
 
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