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Gene Review

CDCA4  -  cell division cycle associated 4

Homo sapiens

Synonyms: Cell division cycle-associated protein 4, FLJ20764, HEPP, Hematopoietic progenitor protein, Hepp, ...
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Disease relevance of CDCA4


High impact information on CDCA4


Chemical compound and disease context of CDCA4


Biological context of CDCA4


Anatomical context of CDCA4

  • Peripheral blood HP cells were similar to bone marrow progenitors in phenotype and clonogenic colony formation capabilities [3].
  • Morphologically, they were typical large granular lymphocytes (LGL), and thus it was indicated that LGL could be differentiated directly from the hematopoietic progenitor cells utterly in vitro by rIL-2 and accessory macrophages [14].
  • NK cells from most of these patients could be activated with rIL-2 to lyse fresh uncultured tumor cells as well as autologous leukemia cells without effecting the peripheral blood HP cells [3].
  • We recently reported the biological activity and some of the biochemical characteristics of a factor produced by a human T cell hybrid clone able to block hematopoietic progenitor cell proliferation [15].
  • Establishment of an adherent cell feeder layer from human umbilical cord blood for support of long-term hematopoietic progenitor cell growth [16].

Associations of CDCA4 with chemical compounds


Regulatory relationships of CDCA4


Other interactions of CDCA4


Analytical, diagnostic and therapeutic context of CDCA4


  1. CDCA4 Is an E2F Transcription Factor Family-induced Nuclear Factor That Regulates E2F-dependent Transcriptional Activation and Cell Proliferation. Hayashi, R., Goto, Y., Ikeda, R., Yokoyama, K.K., Yoshida, K. J. Biol. Chem. (2006) [Pubmed]
  2. Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera. Moliterno, A.R., Hankins, W.D., Spivak, J.L. N. Engl. J. Med. (1998) [Pubmed]
  3. The effects of recombinant interleukin 2-activated natural killer cells on autologous peripheral blood hematopoietic progenitors. Nagler, A., Greenberg, P.L., Lanier, L.L., Phillips, J.H. J. Exp. Med. (1988) [Pubmed]
  4. Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo. Wu, K.D., Cho, Y.S., Katz, J., Ponomarev, V., Chen-Kiang, S., Danishefsky, S.J., Moore, M.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Armstrong, S.A., Staunton, J.E., Silverman, L.B., Pieters, R., den Boer, M.L., Minden, M.D., Sallan, S.E., Lander, E.S., Golub, T.R., Korsmeyer, S.J. Nat. Genet. (2002) [Pubmed]
  6. Suppression of hematopoietic-progenitor-cell proliferation by ethanol and acetaldehyde. Meagher, R.C., Sieber, F., Spivak, J.L. N. Engl. J. Med. (1982) [Pubmed]
  7. Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Gruber, H.E., Finley, K.D., Hershberg, R.M., Katzman, S.S., Laikind, P.K., Seegmiller, J.E., Friedmann, T., Yee, J.K., Jolly, D.J. Science (1985) [Pubmed]
  8. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Broxmeyer, H.E., Bruns, H.A., Zhang, S., Cooper, S., Hangoc, G., McKenzie, A.N., Dent, A.L., Schindler, U., Naeger, L.K., Hoey, T., Kaplan, M.H. Immunity (2002) [Pubmed]
  9. Interferon-alpha restores normal beta 1 integrin-mediated inhibition of hematopoietic progenitor proliferation by the marrow microenvironment in chronic myelogenous leukemia. Bhatia, R., McCarthy, J.B., Verfaillie, C.M. Blood (1996) [Pubmed]
  10. GST-pi gene-transduced hematopoietic progenitor cell transplantation overcomes the bone marrow toxicity of cyclophosphamide in mice. Matsunaga, T., Sakamaki, S., Kuga, T., Kuroda, H., Kusakabe, T., Akiyama, T., Konuma, Y., Hirayama, Y., Kobune, M., Kato, J., Sasaki, K., Kogawa, K., Koyama, R., Niitsu, Y. Hum. Gene Ther. (2000) [Pubmed]
  11. Epirubicin-containing high-dose chemotherapy followed by autologous hematopoietic progenitor cell transfusion for patients with chemotherapy-sensitive metastatic breast cancer: results of 5-year follow-up. Ito, Y., Mukaiyama, T., Ogawa, M., Mizunuma, N., Takahashi, S., Aiba, K., Horikoshi, N. Cancer Chemother. Pharmacol. (1999) [Pubmed]
  12. Inhibition of hematopoietic progenitor cell proliferation by ethanol in human immunodeficiency virus type 1 tat-expressing transgenic mice. Prakash, O., Rodriguez, V.E., Tang, Z.Y., Zhou, P., Coleman, R., Dhillon, G., Shellito, J.E., Nelson, S. Alcohol. Clin. Exp. Res. (2001) [Pubmed]
  13. A phase I study of high-dose BCNU, etoposide and escalating-dose thiotepa (BTE) with hematopoietic progenitor cell support in adults with recurrent and high-risk brain tumors. Papadopoulos, K.P., Balmaceda, C., Fetell, M., Kaufman, E., Vahdat, L.T., Bruce, J., Sisti, M., Isaacson, S., De LaPaz, R., Savage, D.G., Troxel, A., Antman, K.H., Hesdorffer, C.S. J. Neurooncol. (1999) [Pubmed]
  14. Differentiation in vitro of T3+ large granular lymphocytes with characteristic cytotoxic activity from an isolated hematopoietic progenitor colony. Minato, N., Hattori, M., Sudo, T., Kano, S., Miura, Y., Suda, J., Suda, T. J. Exp. Med. (1988) [Pubmed]
  15. Inhibitory effect of a human T cell hybrid factor on both cell growth and mixed lymphocyte reactivity. Correlation with class II molecule expression. Trucco, M., Shaw, S., Korngold, R. J. Clin. Invest. (1985) [Pubmed]
  16. Establishment of an adherent cell feeder layer from human umbilical cord blood for support of long-term hematopoietic progenitor cell growth. Ye, Z.Q., Burkholder, J.K., Qiu, P., Schultz, J.C., Shahidi, N.T., Yang, N.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells. Jacobsen, S.E., Ruscetti, F.W., Longo, D.L., Keller, J.R. J. Natl. Cancer Inst. (1991) [Pubmed]
  18. Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro. Brandt, J., Baird, N., Lu, L., Srour, E., Hoffman, R. J. Clin. Invest. (1988) [Pubmed]
  19. Human hematopoietic progenitor cell isolation based on galactose-specific cell surface binding. Pipia, G.G., Long, M.W. Nat. Biotechnol. (1997) [Pubmed]
  20. A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells. Cheng, J., Daimaru, L., Fennie, C., Lasky, L.A. Blood (1996) [Pubmed]
  21. Limiting-dilution analysis of the effects of colony-stimulating factors, phytohemagglutinin, and hydrocortisone on hematopoietic progenitor cell growth. Takaue, Y., Reading, C.L., Roome, A.J., Dicke, K.A., Tindle, S., Chandran, M., Devaraj, B. Blood (1987) [Pubmed]
  22. Cloning and characterization of exodus, a novel beta-chemokine. Hromas, R., Gray, P.W., Chantry, D., Godiska, R., Krathwohl, M., Fife, K., Bell, G.I., Takeda, J., Aronica, S., Gordon, M., Cooper, S., Broxmeyer, H.E., Klemsz, M.J. Blood (1997) [Pubmed]
  23. Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells. Netelenbos, T., Zuijderduijn, S., Van Den Born, J., Kessler, F.L., Zweegman, S., Huijgens, P.C., Dräger, A.M. J. Leukoc. Biol. (2002) [Pubmed]
  24. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. Hurley, R.W., McCarthy, J.B., Verfaillie, C.M. J. Clin. Invest. (1995) [Pubmed]
  25. The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia. Traweek, S.T., Kandalaft, P.L., Mehta, P., Battifora, H. Am. J. Clin. Pathol. (1991) [Pubmed]
  26. 9.1C3 is identical to LAIR-1, which is expressed on hematopoietic progenitors. Ouyang, W., Ma, D., Lin, D., Sun, Y., Liu, X., Li, Q., Jia, W., Cao, Y., Zhu, Y., Jin, B. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  27. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. Watt, S.M., Bühring, H.J., Rappold, I., Chan, J.Y., Lee-Prudhoe, J., Jones, T., Zannettino, A.C., Simmons, P.J., Doyonnas, R., Sheer, D., Butler, L.H. Blood (1998) [Pubmed]
  28. Hematopoietic progenitor cell expression of the H-CAM (CD44) homing-associated adhesion molecule. Lewinsohn, D.M., Nagler, A., Ginzton, N., Greenberg, P., Butcher, E.C. Blood (1990) [Pubmed]
  29. IL-8 and its CXCR1 and CXCR2 receptors participate in the control of megakaryocytic proliferation, differentiation, and ploidy in myeloid metaplasia with myelofibrosis. Emadi, S., Clay, D., Desterke, C., Guerton, B., Maquarre, E., Charpentier, A., Jasmin, C., Le Bousse-Kerdilès, M.C. Blood (2005) [Pubmed]
  30. Development of drug-resistant herpes simplex virus infection after haploidentical hematopoietic progenitor cell transplantation. Langston, A.A., Redei, I., Caliendo, A.M., Somani, J., Hutcherson, D., Lonial, S., Bucur, S., Cherry, J., Allen, A., Waller, E.K. Blood (2002) [Pubmed]
  31. A prospective randomized trial of buffy coat versus CD34-selected autologous bone marrow support in high-risk breast cancer patients receiving high-dose chemotherapy. Shpall, E.J., LeMaistre, C.F., Holland, K., Ball, E., Jones, R.B., Saral, R., Jacobs, C., Heimfeld, S., Berenson, R., Champlin, R. Blood (1997) [Pubmed]
  32. Purging of mammary carcinoma cells during ex vivo culture of CD34+ hematopoietic progenitor cells with recombinant immunotoxins. Spyridonidis, A., Schmidt, M., Bernhardt, W., Papadimitriou, A., Azemar, M., Wels, W., Groner, B., Henschler, R. Blood (1998) [Pubmed]
  33. Flow cytometry for clinical estimation of circulating hematopoietic progenitors for autologous transplantation in cancer patients. Siena, S., Bregni, M., Brando, B., Belli, N., Ravagnani, F., Gandola, L., Stern, A.C., Lansdorp, P.M., Bonadonna, G., Gianni, A.M. Blood (1991) [Pubmed]
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