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Gene Review

SERTAD1  -  SERTA domain containing 1

Homo sapiens

Synonyms: CDK4-binding protein p34SEI1, SEI-1, SEI1, SERTA domain-containing protein 1, TRIP-Br1, ...
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Disease relevance of SERTAD1

  • (v) The expression levels of SEI-1 and p16 were compared in 32 tumor specimens of human squamous cell carcinomas of the head and neck [1].
  • Here we report yeast two-hybrid screens with HPV-6 and -11 E6 proteins that identified TRIP-Br1 as a novel cellular target [2].
  • These data strongly suggest that SEI-1 plays an important role in the development and progression of ovarian cancer [3].

High impact information on SERTAD1


Biological context of SERTAD1


Other interactions of SERTAD1


Analytical, diagnostic and therapeutic context of SERTAD1


  1. Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). Li, J., Muscarella, P., Joo, S.H., Knobloch, T.J., Melvin, W.S., Weghorst, C.M., Tsai, M.D. Biochemistry (2005) [Pubmed]
  2. The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1. Gupta, S., Takhar, P.P., Degenkolbe, R., Koh, C.H., Zimmermann, H., Yang, C.M., Guan Sim, K., Hsu, S.I., Bernard, H.U. Virology (2003) [Pubmed]
  3. Oncogenic transformation by SEI-1 is associated with chromosomal instability. Tang, D.J., Hu, L., Xie, D., Wu, Q.L., Fang, Y., Zeng, Y., Sham, J.S., Guan, X.Y. Cancer Res. (2005) [Pubmed]
  4. The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner. Li, J., Melvin, W.S., Tsai, M.D., Muscarella, P. Biochemistry (2004) [Pubmed]
  5. Identification of a candidate oncogene SEI-1 within a minimal amplified region at 19q13.1 in ovarian cancer cell lines. Tang, T.C., Sham, J.S., Xie, D., Fang, Y., Huo, K.K., Wu, Q.L., Guan, X.Y. Cancer Res. (2002) [Pubmed]
  6. CDCA4 Is an E2F Transcription Factor Family-induced Nuclear Factor That Regulates E2F-dependent Transcriptional Activation and Cell Proliferation. Hayashi, R., Goto, Y., Ikeda, R., Yokoyama, K.K., Yoshida, K. J. Biol. Chem. (2006) [Pubmed]
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