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Gene Review

gumB  -  GumB protein

Xanthomonas campestris pv. campestris str. ATCC 33913

 
 
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Disease relevance of gumB

  • The Xanthomonas campestris gum gene cluster is composed of 12 genes designated gumB, -C, -D, -E, -F, -G, -H, -I, -J, -K, -L, and -M [1].
  • Xylella fastidiosa gumB and gumF mutants exhibited normal cell characteristics; typical colony morphology and EPS biosynthesis were not altered [2].
 

High impact information on gumB

  • These genes are expressed primarily as an operon from a promoter upstream of the first gene, gumB [3].
  • In contrast, subclones carrying gumB or gumC alone were not effective [4].
  • The biosynthesis of the extracellular polysaccharide xanthan in Xanthomonas campestris pv. campestris is directed by a cluster of 12 genes, gumB-gumM [4].
  • Unlike X. campestris pv. campestris, the expression of the X. fastidiosa gumB or gumF genes was not regulated by glucose [2].
 

Chemical compound and disease context of gumB

  • Evidence for a role for the gumB and gumC gene products in the formation of xanthan from its pentasaccharide repeating unit by Xanthomonas campestris [4].
 

Anatomical context of gumB

  • These results are discussed with reference to previous speculations, based on computer analysis, that gumB and gumC are both involved in the translocation of xanthan across the bacterial membranes [4].
 

Associations of gumB with chemical compounds

  • A subclone of the gum gene cluster carrying gumB and gumC restored xanthan production to strain 8397 to levels approximately 28% of the wild-type [4].

References

  1. Promoter analysis of the Xanthomonas campestris pv. campestris gum operon directing biosynthesis of the xanthan polysaccharide. Katzen, F., Becker, A., Zorreguieta, A., Pühler, A., Ielpi, L. J. Bacteriol. (1996) [Pubmed]
  2. Disruption of Xylella fastidiosa CVC gumB and gumF genes affects biofilm formation without a detectable influence on exopolysaccharide production. Souza, L.C., Wulff, N.A., Gaurivaud, P., Mariano, A.G., Virgílio, A.C., Azevedo, J.L., Monteiro, P.B. FEMS Microbiol. Lett. (2006) [Pubmed]
  3. Expression of the gum operon directing xanthan biosynthesis in Xanthomonas campestris and its regulation in planta. Vojnov, A.A., Slater, H., Daniels, M.J., Dow, J.M. Mol. Plant Microbe Interact. (2001) [Pubmed]
  4. Evidence for a role for the gumB and gumC gene products in the formation of xanthan from its pentasaccharide repeating unit by Xanthomonas campestris. Vojnov, A.A., Zorreguieta, A., Dow, J.M., Daniels, M.J., Dankert, M.A. Microbiology (Reading, Engl.) (1998) [Pubmed]
 
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