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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Loa

  • Differential recognition of Loa loa antigens by sera of human subjects from a loiasis endemic zone [1].
  • While patients with patent Onchocerca volvulus infections were uniformly negative in the Wb-SXP-1 assay, 40% of sera from patent Loa loa infections were positive [2].
  • A trial was therefore conducted to evaluate whether a course of albendazole would bring about a slower decrease in the Loa microfilaraemia, and thus could be used as a mass 'clearing' treatment, before the distribution of ivermectin in areas where onchocerciasis and loiasis are co-endemic [3].
  • 7 cases of Mansonella perstans filariasis and 9 of Loa loa invasion were diagnosed and treated in the clinic of the Institute of Maritime and Tropical Medicine in Gdynia in the years 1993-1999 [4].

High impact information on Loa

  • To determine whether infection with Loa loa could be prevented in temporary residents of endemic areas, we conducted a randomized, double-blind, placebo-controlled trial of diethylcarbamazine as a chemoprophylactic agent [5].
  • Our data indicate that the dynein mutation in the heterozygous state does not affect prion disease incubation time or its neuropathology in Loa mice [6].
  • Most subjects continued to have elevations in microfilaremia, suggesting that more intensive regimens of albendazole will be necessary to reduce Loa microfilaremia to levels safe enough to allow for ivermectin use [7].
  • Interannual variability in global CO2 increment (averaged from the Mauna Loa and South Pole Stations) shows certain strong spatial relationships to both tropical and temperate temperatures [8].
  • Therefore, mebendazole has no direct effect on the microfilarial density of Loa loa [9].

Anatomical context of Loa

  • Although the patient was first seen by us after one month of treatment with Indomethacin, at this time the joints were still inflamed and microfilariae of Loa loa were found in the synovial fluid [10].

Associations of Loa with chemical compounds

  • A microbiological analysis at the Institute of Tropical Medicine confirmed the diagnosis of Loa Loa [11].

Gene context of Loa

  • Matching of ABO blood group and mf infection rates shows that the O blood group has a higher prevalence rate with regard to D. perstans than Loa loa [12].

Analytical, diagnostic and therapeutic context of Loa

  • Circulating antigens isolated from sera of three high-microfilaraemic ( Loa loa) Gabonese patients were fractionated by gel filtration [13].


  1. Differential recognition of Loa loa antigens by sera of human subjects from a loiasis endemic zone. Egwang, T.G., Dupont, A., Leclerc, A., Akué, J.P., Pinder, M. Am. J. Trop. Med. Hyg. (1989) [Pubmed]
  2. The Wuchereria bancrofti orthologue of Brugia malayi SXP1 and the diagnosis of bancroftian filariasis. Rao, K.V., Eswaran, M., Ravi, V., Gnanasekhar, B., Narayanan, R.B., Kaliraj, P., Jayaraman, K., Marson, A., Raghavan, N., Scott, A.L. Mol. Biochem. Parasitol. (2000) [Pubmed]
  3. Effects of a 3-day regimen of albendazole (800 mg daily) on Loa loa microfilaraemia. Tsague-Dongmo, L., Kamgno, J., Pion, S.D., Moyou-Somo, R., Boussinesq, M. Ann. Trop. Med. Parasitol. (2002) [Pubmed]
  4. Diagnosing and treatment of skin filariases based on own observations. Goljan, J., Nahorski, W., Tomaszewski, R., Felczak-Korzybska, I., Górski, J. International maritime health. (2000) [Pubmed]
  5. Diethylcarbamazine prophylaxis for human loiasis. Results of a double-blind study. Nutman, T.B., Miller, K.D., Mulligan, M., Reinhardt, G.N., Currie, B.J., Steel, C., Ottesen, E.A. N. Engl. J. Med. (1988) [Pubmed]
  6. Prion disease incubation time is not affected in mice heterozygous for a dynein mutation. Hafezparast, M., Brandner, S., Linehan, J., Martin, J.E., Collinge, J., Fisher, E.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. Human loiasis in a Cameroonian village: a double-blind, placebo-controlled, crossover clinical trial of a three-day albendazole regimen. Tabi, T.E., Befidi-Mengue, R., Nutman, T.B., Horton, J., Folefack, A., Pensia, E., Fualem, R., Fogako, J., Gwanmesia, P., Quakyi, I., Leke, R. Am. J. Trop. Med. Hyg. (2004) [Pubmed]
  8. Long series relationships between global interannual CO2 increment and climate: evidence for stability and change in role of the tropical and boreal-temperate zones. Adams, J.M., Piovesan, G. Chemosphere (2005) [Pubmed]
  9. Failure of high dose mebendazole as a microfilaricide in patients with loiasis. Burchard, G.D., Kern, P. Trans. R. Soc. Trop. Med. Hyg. (1987) [Pubmed]
  10. Microfilarial polyarthritis in a massive Loa loa infestation. A case report. Bouvet, J.P., Thérizol, M., Auquier, L. Acta Trop. (1977) [Pubmed]
  11. Subconjunctival Loa Loa worm: case report. Carbonez, G., Van De Sompel, W., Zeyen, T. Bulletin de la Société belge d'ophtalmologie. (2002) [Pubmed]
  12. Haemoparasites of blood donors in Calabar. Emeribe, A.O., Ejezie, G.C. Tropical and geographical medicine. (1989) [Pubmed]
  13. Identification and specificity of a 38 kDa Loa loa antigenic fraction in sera from high-microfilaraemic Gabonese patients. Walker-Deemin, A., Ferrer, A., Gauthier, F., Kombila, M., Richard-Lenoble, D. Parasitol. Res. (2004) [Pubmed]
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