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Chemical Compound Review

Bantenol     methyl N-[6-(phenylcarbonyl)-1H...

Synonyms: Madicure, Mebendan, Mebenvet, Vermicol, Vermidil, ...
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Disease relevance of Bantenol


Psychiatry related information on Bantenol


High impact information on Bantenol


Chemical compound and disease context of Bantenol


Biological context of Bantenol

  • Examination of adult worms in nodules excised at 2 months showed changes suggestive of an interruption of embryogenesis in those persons receiving the mebendazole-containing regimens only [8].
  • After the observation of decreasing insulin resistance in a diabetic patient during treatment with mebendazole for nematosis, we investigated the effect of mebendazole on metabolic control in six Type 1 (insulin-dependent) and six Type 2 (non-insulin-dependent) diabetic patients, eight of whom were chronically resistant to conventional treatment [13].
  • This lack of normalization was associated with lower bioavailability of mebendazole [14].
  • Since lack of intestinal absorption makes mebendazole an attractive new antigiardial agent, its in vitro activity was further characterized [15].
  • Four derivatives, including mebendazole and albendazole, had moderately high activities (IC50 = 0.1 to 0.3 microgram/ml) [16].

Anatomical context of Bantenol


Associations of Bantenol with other chemical compounds


Gene context of Bantenol

  • Because the synthesis of interferon gamma (IFN-gamma) and IFN-alpha is markedly decreased in patients with echinococcosis, we treated our patient with IFN-gamma while continuing mebendazole therapy [24].
  • The lower cumulative food intake and weight gain of all infected rats after 8 days of infection were accompanied by elevated plasma insulin and, in some individuals, by elevated plasma leptin, compared with uninfected controls and previously-infected MBZ-treated rats [25].
  • Messenger RNA levels for neuropeptide Y were higher in the hypothalamic arcuate nucleus of 8-day infected rats than in recovering MBZ-treated animals [25].
  • Intestinal tubulin as possible target for the chemotherapeutic action of mebendazole in parasitic nematodes [26].
  • These observations suggest that the benzimidazoles, albendazole and mebendazole, may interact with protease inhibitors, which are known for their strong inhibition of the CYP3A4 [27].

Analytical, diagnostic and therapeutic context of Bantenol


  1. Mebendazole therapy of parenteral trichinellosis. McCracken, R.O., Taylor, D.D. Science (1980) [Pubmed]
  2. Severe, reversible neutropenia during high-dose mebendazole therapy for echinococcosis. Levin, M.H., Weinstein, R.A., Axelrod, J.L., Schantz, P.M. JAMA (1983) [Pubmed]
  3. Effect of mebendazole therapy during pregnancy on birth outcome. de Silva, N.R., Sirisena, J.L., Gunasekera, D.P., Ismail, M.M., de Silva, H.J. Lancet (1999) [Pubmed]
  4. 12 month follow-up of mebendazole therapy for onchocerciasis. Rivas-Alcala, A.R., Greene, B.M., Taylor, H.R., Domiguez-Vaques, A., Ruvalcaba-Macias, A.M., Lugo-Pfeiffer, C., Beltran-Hernandez, F. Lancet (1981) [Pubmed]
  5. Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. Stoltzfus, R.J., Kvalsvig, J.D., Chwaya, H.M., Montresor, A., Albonico, M., Tielsch, J.M., Savioli, L., Pollitt, E. BMJ (2001) [Pubmed]
  6. Cerebral cysticercosis presenting as progressive dementia. Sandyk, R., Bamford, C., Iacono, R.P., Gillman, M.A. Int. J. Neurosci. (1987) [Pubmed]
  7. Mebendazole treatment of loaiasis. Van Hoegaerden, M., Flocard, F. Lancet (1985) [Pubmed]
  8. Chemotherapy of onchocerciasis: a controlled comparison of mebendazole, levamisole, and diethylcarbamazine. Rivas-Alcalá, A.R., Greene, B.M., Taylor, H.R., Domíguez-Vázquez, A., Ruvalcaba-Macías, A.M., Lugo-Pfeiffer, C., Mackenzie, C.D., Beltrán, F. Lancet (1981) [Pubmed]
  9. Reducing intestinal nematode infection: efficacy of albendazole and mebendazole. Bennett, A., Guyatt, H. Parasitol. Today (Regul. Ed.) (2000) [Pubmed]
  10. Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo. Mukhopadhyay, T., Sasaki, J., Ramesh, R., Roth, J.A. Clin. Cancer Res. (2002) [Pubmed]
  11. Anthelmintics. Current concepts in the treatment of helminthic infections. Katz, M. Drugs (1986) [Pubmed]
  12. Comparative efficacy of ketoconazole and mebendazole in experimental trichinosis. Hess, J.A., Chandrasekar, P.H., Mortiere, M., Molinari, J.A. Antimicrob. Agents Chemother. (1986) [Pubmed]
  13. Improvement of metabolic control in diabetic patients during mebendazole administration: preliminary studies. Caprio, S., Ray, T.K., Boden, G., Reichard, G.A., Shuman, C.R., Smith, R.H., Mozzoli, M.A., Dayal, V.K., Hoeldtke, R.D., Owen, O.E. Diabetologia (1984) [Pubmed]
  14. Immunosurveillance of alveolar echinococcosis by specific humoral and cellular immune tests: long-term analysis of the Swiss chemotherapy trial (1976-2001). Ammann, R.W., Renner, E.C., Gottstein, B., Grimm, F., Eckert, J., Renner, E.L. J. Hepatol. (2004) [Pubmed]
  15. Activity of the anthelmintic benzimidazoles against Giardia lamblia in vitro. Edlind, T.D., Hang, T.L., Chakraborty, P.R. J. Infect. Dis. (1990) [Pubmed]
  16. In vitro susceptibility of the opportunistic fungus Cryptococcus neoformans to anthelmintic benzimidazoles. Cruz, M.C., Bartlett, M.S., Edlind, T.D. Antimicrob. Agents Chemother. (1994) [Pubmed]
  17. Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice. Du, W.Y., Liao, J.W., Fan, C.K., Su, K.E. Infect. Immun. (2003) [Pubmed]
  18. Clinical pharmacokinetics of anthelmintic drugs. Edwards, G., Breckenridge, A.M. Clinical pharmacokinetics. (1988) [Pubmed]
  19. Trichinella spiralis-infected muscle cells: abundant RNA polymerase II in nuclear speckle domains colocalizes with nuclear antigens. Yao, C., Jasmer, D.P. Infect. Immun. (2001) [Pubmed]
  20. Mebendazole. Keystone, J.S., Murdoch, J.K. Ann. Intern. Med. (1979) [Pubmed]
  21. A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum. Cappello, M., Bungiro, R.D., Harrison, L.M., Bischof, L.J., Griffitts, J.S., Barrows, B.D., Aroian, R.V. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  22. Inhibition of acetylcholinesterase secretion from Nippostrongylus brasiliensis by benzimidazole anthelmintics. Watts, S.D., Rapson, E.B., Atkins, A.M., Lee, D.L. Biochem. Pharmacol. (1982) [Pubmed]
  23. Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan. Chen, K.T., Twu, S.J., Chang, H.J., Lin, R.S. American journal of public health. (2003) [Pubmed]
  24. Use of interferon gamma and mebendazole to stop the progression of alveolar hydatid disease: case report. Schmid, M., Samonigg, H., Stöger, H., Auer, H., Sternthal, M.H., Wilders-Truschnig, M., Reisinger, E.C. Clin. Infect. Dis. (1995) [Pubmed]
  25. Anorexia in rats infected with the nematode, Nippostrongylus brasiliensis: experimental manipulations. Mercer, J.G., Mitchell, P.I., Moar, K.M., Bissett, A., Geissler, S., Bruce, K., Chappell, L.H. Parasitology (2000) [Pubmed]
  26. Intestinal tubulin as possible target for the chemotherapeutic action of mebendazole in parasitic nematodes. Köhler, P., Bachmann, R. Mol. Biochem. Parasitol. (1981) [Pubmed]
  27. Alveolar echinococcosis of the liver in an adult with human immunodeficiency virus type-1 infection. Zingg, W., Renner-Schneiter, E.C., Pauli-Magnus, C., Renner, E.L., van Overbeck, J., Schläpfer, E., Weber, M., Weber, R., Opravil, M., Gottstein, B., Speck, R.F. Infection (2004) [Pubmed]
  28. In vitro activities of benzimidazoles against Echinococcus multilocularis metacestodes. Jura, H., Bader, A., Frosch, M. Antimicrob. Agents Chemother. (1998) [Pubmed]
  29. In Vitro Metacestodicidal Activities of Genistein and Other Isoflavones against Echinococcus multilocularis and Echinococcus granulosus. Naguleswaran, A., Spicher, M., Vonlaufen, N., Ortega-Mora, L.M., Torgerson, P., Gottstein, B., Hemphill, A. Antimicrob. Agents Chemother. (2006) [Pubmed]
  30. Treatment failures following mebendazole therapy for chronic strongyloidiasis. Pelletier, L.L., Baker, C.B. J. Infect. Dis. (1987) [Pubmed]
  31. Hepatic echinococcosis ruptured into the biliary tract. Clinical, radiological and therapeutic features during five episodes of spontaneous biliary rupture in three patients with hepatic hydatidosis. Van Steenbergen, W., Fevery, J., Broeckaert, L., Ponette, E., Marchal, G., Baert, A., Penninckx, F., Kerremans, R., De Groote, J. J. Hepatol. (1987) [Pubmed]
  32. Assay of mebendazole in tablets by high-performance liquid chromatography. Wang, D.P., Lo, H.S. The Analyst. (1984) [Pubmed]
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