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MeSH Review


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Disease relevance of Onchocerciasis


High impact information on Onchocerciasis


Chemical compound and disease context of Onchocerciasis


Biological context of Onchocerciasis


Anatomical context of Onchocerciasis


Gene context of Onchocerciasis

  • In contrast, PBMC from onchocerciasis patients clearly produced more IL-10 than did cells from endemic normals [23].
  • The cutaneous T cell-attracting chemokine (CTACK/CCL27) was found highly elevated in onchocerciasis patients compared to infection-free European controls (P = 0.0004) and it did not change following ivermectin or placebo to 1 year post-therapy [24].
  • The roles of eotaxin, RANTES, and MCP-3 expression in eosinophil recruitment to the site of parasite killing that occurs following ivermectin treatment of onchocerciasis were assessed in the skin of 13 Onchocerca volvulus-infected subjects and two noninfected controls before and after ivermectin treatment [20].
  • Regulation of IL-5 in onchocerciasis. A critical role for IL-2 [25].
  • These findings suggest that IL-2 production is required to induce IL-5 and further implicates IL-5 as a possible mediator of protection in onchocerciasis [25].

Analytical, diagnostic and therapeutic context of Onchocerciasis


  1. Immunological crossreactivity between a cloned antigen of Onchocerca volvulus and a component of the retinal pigment epithelium. Braun, G., McKechnie, N.M., Connor, V., Gilbert, C.E., Engelbrecht, F., Whitworth, J.A., Taylor, D.W. J. Exp. Med. (1991) [Pubmed]
  2. Serological cross-reactivity between a human Ro/SS-A autoantigen (calreticulin) and the lambda Ral-1 antigen of Onchocerca volvulus. Lux, F.A., McCauliffe, D.P., Büttner, D.W., Lucius, R., Capra, J.D., Sontheimer, R.D., Lieu, T.S. J. Clin. Invest. (1992) [Pubmed]
  3. Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. Limaye, A.P., Abrams, J.S., Silver, J.E., Awadzi, K., Francis, H.F., Ottesen, E.A., Nutman, T.B. J. Clin. Invest. (1991) [Pubmed]
  4. Proteinuria associated with diethylcarbamazine treatment of onchocerciasis. Greene, B.M., Taylor, H.R., Humphrey, R.L. Lancet (1980) [Pubmed]
  5. Suramin affects DNA synthesis in HeLa cells by inhibition of DNA polymerases. Jindal, H.K., Anderson, C.W., Davis, R.G., Vishwanatha, J.K. Cancer Res. (1990) [Pubmed]
  6. Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. Greene, B.M., Taylor, H.R., Cupp, E.W., Murphy, R.P., White, A.T., Aziz, M.A., Schulz-Key, H., D'Anna, S.A., Newland, H.S., Goldschmidt, L.P. N. Engl. J. Med. (1985) [Pubmed]
  7. Molecular cloning and characterization of recombinant parasite antigens for immunodiagnosis of onchocerciasis. Chandrashekar, R., Masood, K., Alvarez, R.M., Ogunrinade, A.F., Lujan, R., Richards, F.O., Weil, G.J. J. Clin. Invest. (1991) [Pubmed]
  8. Depletion of wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment. Hoerauf, A., Mand, S., Adjei, O., Fleischer, B., Büttner, D.W. Lancet (2001) [Pubmed]
  9. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection. Gardon, J., Gardon-Wendel, N., Demanga-Ngangue, n.u.l.l., Kamgno, J., Chippaux, J.P., Boussinesq, M. Lancet (1997) [Pubmed]
  10. Suramin and eosinophil degranulation and vacuolation in onchocerciasis. Newsome, F. Lancet (1987) [Pubmed]
  11. 12 month follow-up of mebendazole therapy for onchocerciasis. Rivas-Alcala, A.R., Greene, B.M., Taylor, H.R., Domiguez-Vaques, A., Ruvalcaba-Macias, A.M., Lugo-Pfeiffer, C., Beltran-Hernandez, F. Lancet (1981) [Pubmed]
  12. Chloroquine and onchocerciasis. Guderian, R.H., Williams, J.F., Mackenzie, C.D. Lancet (1986) [Pubmed]
  13. Chemotherapy of onchocerciasis: a controlled comparison of mebendazole, levamisole, and diethylcarbamazine. Rivas-Alcalá, A.R., Greene, B.M., Taylor, H.R., Domíguez-Vázquez, A., Ruvalcaba-Macías, A.M., Lugo-Pfeiffer, C., Mackenzie, C.D., Beltrán, F. Lancet (1981) [Pubmed]
  14. Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. Dominguez-Vazquez, A., Taylor, H.R., Greene, B.M., Ruvalcaba-Macias, A.M., Rivas-Alcala, A.R., Murphy, R.P., Beltran-Hernandez, F. Lancet (1983) [Pubmed]
  15. Immunoblot evaluation of the 100 and 130 kDa antigens in camel hydatid cyst fluid for the serodiagnosis of human cystic echinococcosis in Libya. Shambesh, M.K., Craig, P.S., Gusbi, A.M., Echtuish, E.F., Wen, H. Trans. R. Soc. Trop. Med. Hyg. (1995) [Pubmed]
  16. Relationships between mortality, visual acuity and microfilarial load in the area of the Onchocerciasis Control Programme. Kirkwood, B., Smith, P., Marshall, T., Prost, A. Trans. R. Soc. Trop. Med. Hyg. (1983) [Pubmed]
  17. Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms. Hoerauf, A., Mand, S., Volkmann, L., Büttner, M., Marfo-Debrekyei, Y., Taylor, M., Adjei, O., Büttner, D.W. Microbes Infect. (2003) [Pubmed]
  18. Interleukin-12 modulates T-cell responses to microfilariae but fails to abrogate interleukin-5-dependent immunity in a mouse model of onchocerciasis. Hogarth, P.J., Bianco, A.E. Immunology (1999) [Pubmed]
  19. Immunopathology of ocular onchocerciasis. I. Inflammatory cells infiltrating the anterior segment. Chan, C.C., Ottesen, E.A., Awadzi, K., Badu, R., Nussenblatt, R.B. Clin. Exp. Immunol. (1989) [Pubmed]
  20. Eotaxin and RANTES expression by the dermal endothelium is associated with eosinophil infiltration after ivermectin treatment of onchocerciasis. Cooper, P.J., Beck, L.A., Espinel, I., Deyampert, N.M., Hartnell, A., Jose, P.J., Paredes, W., Guderian, R.H., Nutman, T.B. Clin. Immunol. (2000) [Pubmed]
  21. Pathophysiological roles of calreticulin in autoimmune disease. Eggleton, P., Llewellyn, D.H. Scand. J. Immunol. (1999) [Pubmed]
  22. Microfilariae in the cerebrospinal fluid, and neurological complications, during treatment of onchocerciasis with diethylcarbamazine. Duke, B.O., Vincelette, J., Moore, P.J. Tropenmedizin und Parasitologie. (1976) [Pubmed]
  23. Immunoregulation in onchocerciasis: predominance of Th1-type responsiveness to low molecular weight antigens of Onchocerca volvulus in exposed individuals without microfilaridermia and clinical disease. Lüder, C.G., Schulz-Key, H., Banla, M., Pritze, S., Soboslay, P.T. Clin. Exp. Immunol. (1996) [Pubmed]
  24. Chemokines in onchocerciasis patients after a single dose of ivermectin. Fendt, J., Hamm, D.M., Banla, M., Schulz-Key, H., Wolf, H., Helling-Giese, G., Heuschkel, C., Soboslay, P.T. Clin. Exp. Immunol. (2005) [Pubmed]
  25. Regulation of IL-5 in onchocerciasis. A critical role for IL-2. Steel, C., Nutman, T.B. J. Immunol. (1993) [Pubmed]
  26. Double-blind study of ivermectin and diethylcarbamazine in African onchocerciasis patients with ocular involvement. Lariviere, M., Vingtain, P., Aziz, M., Beauvais, B., Weimann, D., Derouin, F., Ginoux, J., Schulz-Key, H., Gaxotte, P., Basset, D. Lancet (1985) [Pubmed]
  27. Homologous and distinctive antigens of Onchocerca volvulus and Dirofilaria immitis: detection by an enzyme-linked immuno-inhibition assay. Boto, W.M., D'Antonio, R., Levy, D.A. J. Immunol. (1984) [Pubmed]
  28. Interleukin-6 and tumor necrosis factor in the pathogenesis of adverse reactions after treatment of lymphatic filariasis and onchocerciasis. Turner, P.F., Rockett, K.A., Ottesen, E.A., Francis, H., Awadzi, K., Clark, I.A. J. Infect. Dis. (1994) [Pubmed]
  29. Major retinal cell components recognized by onchocerciasis sera are associated with the cell surface and nucleoli. Zhou, Y., Dziak, E., Unnasch, T.R., Opas, M. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  30. Humoral autoimmune response against S-antigen and IRBP in ocular onchocerciasis. Van der Lelij, A., Doekes, G., Hwan, B.S., Vetter, J.C., Rietveld, E., Stilma, J.S., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
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