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MeSH Review


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Disease relevance of Nairovirus


High impact information on Nairovirus

  • Moreover, expression of a distantly related nucleoprotein gene from Crimean-Congo hemorrhagic fever nairovirus failed to induce HAZV silencing, indicating that the inhibition is sequence specific [2].
  • Interestingly, additional regions containing putative Ovarian Tumor (OTU)-like cysteine protease and helicase domains were identified in the L segments of CCHF and Dugbe viruses, suggesting an autoproteolytic cleavage process for nairovirus L proteins [3].
  • This can encode a 483 amino acid polypeptide, M(r) 53.9 kDa, corresponding to the viral nucleocapsid protein N. The DUG N protein is thus similar in length to the N proteins of Hazara (HAZ) and Crimean-Congo haemorrhagic fever (CCHF) nairoviruses, which are 485 and 482 amino acids in length, respectively [4].
  • Large RNA segment of Dugbe nairovirus encodes the putative RNA polymerase [5].
  • When tested with laboratory animal sera representing all seven serogroups of nairoviruses, the only reactive sera were those raised to CCHF virus (Greek, Nigerian and Chinese isolates) and, more weakly, Hazara virus [6].

Chemical compound and disease context of Nairovirus

  • Immunosuppression of i.n. inoculated adult mice with cyclophosphamide produced some mortality indicating that host defences are important in protecting the adult, especially as newborn and adult lung tissue were equally able to support the growth of Dugbe virus in culture [7].

Anatomical context of Nairovirus


  1. Avalon virus, Sakhalin group (Nairovirus, Bunyaviridae) from the seabird tick Ixodes (Ceratixodes) uriae White 1852 in France. Quillien, M.C., Monnat, J.Y., Le Lay, G., Le Goff, F., Hardy, E., Chastel, C. Acta Virol. (1986) [Pubmed]
  2. Nairovirus RNA sequences expressed by a Semliki Forest virus replicon induce RNA interference in tick cells. Garcia, S., Billecocq, A., Crance, J.M., Munderloh, U., Garin, D., Bouloy, M. J. Virol. (2005) [Pubmed]
  3. Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment. Kinsella, E., Martin, S.G., Grolla, A., Czub, M., Feldmann, H., Flick, R. Virology (2004) [Pubmed]
  4. Dugbe nairovirus S segment: correction of published sequence and comparison of five isolates. Bridgen, A., Dalrymple, D.A., Elliott, R.M. Virology (2002) [Pubmed]
  5. Large RNA segment of Dugbe nairovirus encodes the putative RNA polymerase. Marriott, A.C., Nuttall, P.A. J. Gen. Virol. (1996) [Pubmed]
  6. Detection of human antibodies to Crimean-Congo haemorrhagic fever virus using expressed viral nucleocapsid protein. Marriott, A.C., Polyzoni, T., Antoniadis, A., Nuttall, P.A. J. Gen. Virol. (1994) [Pubmed]
  7. Studies on the pathogenicity of a nairovirus, Dugbe virus, in normal and immunosuppressed mice. Coates, D.M., Sweet, C. J. Gen. Virol. (1990) [Pubmed]
  8. Expression of the nucleocapsid protein of Dugbe virus and antigenic cross-reactions with other nairoviruses. Ward, V.K., Marriott, A.C., Polyzoni, T., el-Ghorr, A.A., Antoniadis, A., Nuttall, P.A. Virus Res. (1992) [Pubmed]
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