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Gene Review

Abcg1  -  ATP-binding cassette, sub-family G (WHITE)...

Mus musculus

Synonyms: ATP-binding cassette sub-family G member 1, ATP-binding cassette transporter 8, AW413978, Abc8, White, ...
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Disease relevance of Abcg1


Psychiatry related information on Abcg1

  • LR White embedding allows a multi-method approach to the analysis of brain tissue from patients with Alzheimer's disease [6].

High impact information on Abcg1


Chemical compound and disease context of Abcg1


Biological context of Abcg1

  • The demonstration that Abcg1(-/-) macrophages undergo accelerated apoptosis provides a mechanism to explain the decrease in the atherosclerotic lesions [16].
  • The murine Abcg1 gene is reported to consist of 15 exons that encode a single mRNA (herein referred to as Abcg1-a) and protein [17].
  • In NZO mice, an Abcg1 variant was identified in a suggestive adiposity quantitative trait locus and was associated with higher expression of the gene in white adipose tissue [1].
  • Cyp26A1 expression is inducible by RA, and the locus has previously been shown to contain a RARE (RA response element), R1, within the minimal promoter [Loudig, Babichuk, White, Abu-Abed, Mueller and Petkovich (2000) Mol. Endocrinol. 14, 1483-1497] [18].
  • Eight of approximately 100 cell lines derived at the Scott and White Clinic from human solid tumors were found to have the same phenotypes when analyzed for 15 polymorphic enzymes at the Sloan-Kettering Institute for Cancer Research. These data were confirmed at the M [19].

Anatomical context of Abcg1

  • CONCLUSIONS: These studies reveal an inverse relationship between Abcg1 expression and apoE accumulation and secretion in macrophages [20].
  • Plasma apoE levels were markedly increased in recipients of Abcg1(-/-) bone marrow [20].
  • OBJECTIVE: The lungs of Abcg1(-/-) mice accumulate macrophage foam cells that contain high levels of unesterified and esterified cholesterol, consistent with a role for ABCG1 in facilitating the efflux of cholesterol from macrophages to high-density lipoprotein (HDL) and other exogenous sterol acceptors [16].
  • The reduction of adipose tissue mass in Abcg1-/- mice was associated with markedly decreased size of the adipocytes [1].
  • Targeted disruption of Abcg1 in mice has no effect on plasma lipids but results in massive accumulation of both neutral lipids and phospholipids in hepatocytes and in macrophages within multiple tissues following administration of a high-fat and -cholesterol diet [21].

Associations of Abcg1 with chemical compounds

  • Insertion of modified transposable elements of the P-family upstream of CG17646, the Drosophila ortholog of Abcg1, generated lines of flies with increased triglyceride stores [1].
  • To examine the in vivo effects of a kinase-deficient mutant human insulin receptor, we used the muscle creatine kinase promoter to express a putative dominant-negative receptor: Ala1134-->Thr (Moller, D. E., Yokota, A., White, M. F., Pazianos, A. G., and Flier, J. S. (1990) J. Biol. Chem. 265, 14979-14985) in transgenic mice [22].
  • Autoimmune female New Zealand Black/New Zealand White mice were treated with frentizole, an experimental immunosuppressive drug [23].
  • Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury [24].
  • New Zealand White rabbits (n = 33) were given TGF-beta(2) (1.7 or 5.0 microg), talc (400 mg/kg), doxycycline (10 mg/kg), or buffer intrapleurally [25].

Other interactions of Abcg1

  • Abca1 knockdown prevented the increase in apoE secretion but had minimal effects on apoE accumulation in cell lysates of Abcg1(-/-) macrophages [20].
  • METHODS AND RESULTS: Bone marrow from Abcg1(-/-) mice was transplanted into irradiated Ldlr(-/-) recipients, and atherosclerosis was evaluated by aortic root assay after 7 or 11 weeks of feeding on a Western diet [20].
  • METHODS AND RESULTS: Bone marrow from wild-type or Abcg1(-/-) mice was transplanted into Ldlr(-/-) or ApoE(-/-) mice [16].
  • Sle1 on chromosome 1 and Sle3/5 on chromosome 7 are two of the most critical lupus susceptibility loci of the New Zealand Black/White-derived NZM2410 mouse strain [26].
  • These SDKs were previously shown to phosphorylate endogenous 14-3-3 proteins (Megidish, T., White, T., Takio, K., Titani, K., Igarashi, Y., and Hakomori, S. (1995) Biochem. Biophys. Res. Commun. 216, 739-747) [27].

Analytical, diagnostic and therapeutic context of Abcg1


  1. Ablation of the cholesterol transporter adenosine triphosphate-binding cassette transporter G1 reduces adipose cell size and protects against diet-induced obesity. Buchmann, J., Meyer, C., Neschen, S., Augustin, R., Schmolz, K., Kluge, R., Al-Hasani, H., Jürgens, H., Eulenberg, K., Wehr, R., Dohrmann, C., Joost, H.G., Schürmann, A. Endocrinology (2007) [Pubmed]
  2. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Clynes, R., Dumitru, C., Ravetch, J.V. Science (1998) [Pubmed]
  3. Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA. Gilkeson, G.S., Ruiz, P., Pippen, A.M., Alexander, A.L., Lefkowith, J.B., Pisetsky, D.S. J. Exp. Med. (1996) [Pubmed]
  4. Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone. Lucas, J.A., Ahmed, S.A., Casey, M.L., MacDonald, P.C. J. Clin. Invest. (1985) [Pubmed]
  5. Prevention of glomerulonephritis and prolonged survival in New Zealand Black/New Zealand White F1 hybrid mice fed an essential fatty acid-deficient diet. Hurd, E.R., Johnston, J.M., Okita, J.R., MacDonald, P.C., Ziff, M., Gilliam, J.W. J. Clin. Invest. (1981) [Pubmed]
  6. LR White embedding allows a multi-method approach to the analysis of brain tissue from patients with Alzheimer's disease. Singhrao, S., Cole, G., Henderson, W.J., Newman, G.R. Histochem. J. (1990) [Pubmed]
  7. Alternative splicing of murine T-cell receptor beta-chain transcripts. Behlke, M.A., Loh, D.Y. Nature (1986) [Pubmed]
  8. The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor. Besmer, P. Curr. Opin. Cell Biol. (1991) [Pubmed]
  9. Rabbit model of Lyme borreliosis: erythema migrans, infection-derived immunity, and identification of Borrelia burgdorferi proteins associated with virulence and protective immunity. Foley, D.M., Gayek, R.J., Skare, J.T., Wagar, E.A., Champion, C.I., Blanco, D.R., Lovett, M.A., Miller, J.N. J. Clin. Invest. (1995) [Pubmed]
  10. Ability of the xid gene to prevent autoimmunity in (NZB X NZW)F1 mice during the course of their natural history, after polyclonal stimulation, or following immunization with DNA. Steinberg, B.J., Smathers, P.A., Frederiksen, K., Steinberg, A.D. J. Clin. Invest. (1982) [Pubmed]
  11. Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein. Gilbert, J.M., Hernandez, L.D., Balliet, J.W., Bates, P., White, J.M. J. Virol. (1995) [Pubmed]
  12. Impact of LY146032 on Streptococcus (Enterococcus) faecalis translocation in mice. Dougherty, S.H., Hentges, D.J., Casey, S.W., Thal, W.R. Antimicrob. Agents Chemother. (1988) [Pubmed]
  13. Glucocorticoid ameliorates altered gene expression of extracellular matrix components in kidneys of New Zealand black/white F1 mice. Nakamura, T., Ebihara, I., Tomino, Y., Koide, H. Clin. Sci. (1992) [Pubmed]
  14. Chemical exposure of embryos during the preimplantation stages of pregnancy: mortality rate and intrauterine development. Fabro, S., McLachlan, J.A., Dames, N.M. Am. J. Obstet. Gynecol. (1984) [Pubmed]
  15. Detection of Escherichia coli O157:H7 using chicken immunoglobulin Y. Sunwoo, H.H., Wang, W.W., Sim, J.S. Immunol. Lett. (2006) [Pubmed]
  16. Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr-/- and ApoE-/- Mice Transplanted With Abcg1-/- Bone Marrow. Baldán, A., Pei, L., Lee, R., Tarr, P., Tangirala, R.K., Weinstein, M.M., Frank, J., Li, A.C., Tontonoz, P., Edwards, P.A. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  17. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. Nakamura, K., Kennedy, M.A., Baldán, A., Bojanic, D.D., Lyons, K., Edwards, P.A. J. Biol. Chem. (2004) [Pubmed]
  18. Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility. Loudig, O., Maclean, G.A., Dore, N.L., Luu, L., Petkovich, M. Biochem. J. (2005) [Pubmed]
  19. Detection and analysis of a glucose 6-phosphate dehydrogenase phenotype B cell line contamination. Lelbovitz, A., Wright, W.C., Pathak, S., Siciliano, M.J., Daniels, W.P. J. Natl. Cancer Inst. (1979) [Pubmed]
  20. Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with abcg1-/- bone marrow. Ranalletta, M., Wang, N., Han, S., Yvan-Charvet, L., Welch, C., Tall, A.R. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  21. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Kennedy, M.A., Barrera, G.C., Nakamura, K., Baldán, A., Tarr, P., Fishbein, M.C., Frank, J., Francone, O.L., Edwards, P.A. Cell metabolism. (2005) [Pubmed]
  22. Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice. Chang, P.Y., Benecke, H., Le Marchand-Brustel, Y., Lawitts, J., Moller, D.E. J. Biol. Chem. (1994) [Pubmed]
  23. Prolonged lifespans in female NZB/NZW mice treated with the experimental immunoregulatory drug frentizole. Walker, S.E., Solsky, M., Schnitzer, B. Arthritis Rheum. (1982) [Pubmed]
  24. Tumor necrosis factor and IL-1 in New Zealand Black/White mice. Enhanced gene expression and acceleration of renal injury. Brennan, D.C., Yui, M.A., Wuthrich, R.P., Kelley, V.E. J. Immunol. (1989) [Pubmed]
  25. Transforming growth factor beta induces vascular endothelial growth factor elaboration from pleural mesothelial cells in vivo and in vitro. Gary Lee, Y.C., Melkerneker, D., Thompson, P.J., Light, R.W., Lane, K.B. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  26. Genetic dissection of systemic lupus erythematosus pathogenesis: partial functional complementation between Sle1 and Sle3/5 demonstrates requirement for intracellular coexpression for full phenotypic expression of lupus. Wakui, M., Morel, L., Butfiloski, E.J., Kim, C., Sobel, E.S. J. Immunol. (2005) [Pubmed]
  27. A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. Megidish, T., Cooper, J., Zhang, L., Fu, H., Hakomori, S. J. Biol. Chem. (1998) [Pubmed]
  28. Unilateral nephrectomy: effect on survival in NZB/NZW mice. Beyer, M.M., Steinberg, A.D., Nicastri, A.D., Friedman, E.A. Science (1977) [Pubmed]
  29. Upregulation of estrogen receptor-alpha expression in rabbit cardiac allograft. Lou, H., Martin, M.B., Stoica, A., Ramwell, P.W., Foegh, M.L. Circ. Res. (1998) [Pubmed]
  30. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. Scalapino, K.J., Tang, Q., Bluestone, J.A., Bonyhadi, M.L., Daikh, D.I. J. Immunol. (2006) [Pubmed]
  31. Orderly pattern of development of the autoantibody response in (New Zealand White x BXSB)F1 lupus mice: characterization of target antigens and antigen spreading by two-dimensional gel electrophoresis and mass spectrometry. Thébault, S., Gilbert, D., Hubert, M., Drouot, L., Machour, N., Lange, C., Charlionet, R., Tron, F. J. Immunol. (2002) [Pubmed]
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