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DUGVsSgp1  -  nucleocapsid protein

Dugbe virus

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Disease relevance of DUGVsSgp1

  • This can encode a 483 amino acid polypeptide, M(r) 53.9 kDa, corresponding to the viral nucleocapsid protein N. The DUG N protein is thus similar in length to the N proteins of Hazara (HAZ) and Crimean-Congo haemorrhagic fever (CCHF) nairoviruses, which are 485 and 482 amino acids in length, respectively [1].
  • N protein trimers from the Andes, Puumala, Prospect Hill, Seoul, and Sin Nombre viruses recognize their individual homologous panhandles as well as other hantavirus panhandles with high affinity [2].
  • The 49.4-kDa product was expressed as a fusion protein with beta-galactosidase in Escherichia coli cells and confirmed as DUG N protein by Western blotting with DUG N-specific monoclonal antibody [3].
  • The nucleocapsid protein N accumulated in scattered foci throughout the cytoplasm, and this appears to be related to the limited maturation of DUG virus particles that occurred [4].
  • Monoclonal and polyclonal antibodies to the N protein of Crimean-Congo haemorrhagic fever (CCHF) virus were found to cross-react weakly with the baculovirus expressed DUG N protein by Western blotting [5].

High impact information on DUGVsSgp1


Analytical, diagnostic and therapeutic context of DUGVsSgp1

  • Western and Northern blot analyses showed significantly lower DUGV nucleocapsid (N) protein expression and DUGV genomic RNA, respectively, in the presence of MxA [8].


  1. Dugbe nairovirus S segment: correction of published sequence and comparison of five isolates. Bridgen, A., Dalrymple, D.A., Elliott, R.M. Virology (2002) [Pubmed]
  2. Hantavirus N protein exhibits genus-specific recognition of the viral RNA panhandle. Mir, M.A., Brown, B., Hjelle, B., Duran, W.A., Panganiban, A.T. J. Virol. (2006) [Pubmed]
  3. Coding strategy of the S RNA segment of Dugbe virus (Nairovirus; Bunyaviridae). Ward, V.K., Marriott, A.C., el-Ghorr, A.A., Nuttall, P.A. Virology (1990) [Pubmed]
  4. Structure and morphogenesis of Dugbe virus (Bunyaviridae, Nairovirus) studied by immunogold electron microscopy of ultrathin cryosections. Booth, T.F., Gould, E.A., Nuttall, P.A. Virus Res. (1991) [Pubmed]
  5. Expression of the nucleocapsid protein of Dugbe virus and antigenic cross-reactions with other nairoviruses. Ward, V.K., Marriott, A.C., Polyzoni, T., el-Ghorr, A.A., Antoniadis, A., Nuttall, P.A. Virus Res. (1992) [Pubmed]
  6. Nairobi sheep disease virus, an important tick-borne pathogen of sheep and goats in Africa, is also present in Asia. Marczinke, B.I., Nichol, S.T. Virology (2002) [Pubmed]
  7. Persistent infection of Aedes albopictus C6/36 cells by Bunyamwera virus. Elliott, R.M., Wilkie, M.L. Virology (1986) [Pubmed]
  8. Inhibition of Dugbe nairovirus replication by human MxA protein. Bridgen, A., Dalrymple, D.A., Weber, F., Elliott, R.M. Virus Res. (2004) [Pubmed]
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