High impact information on pha-1

• The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development [1].
• A mosaic analysis of the requirement of pha-1 activity during pharynx formation is consistent with the notion that pha-1 acts cell-autonomously in all cells of the pharynx primordium [2].
• The data suggest that pha-1 initiates and coordinates programs required for cytodifferentiation and morphogenesis in all cell types of the entire organ on the transcriptional level [2].
• Mutations in the zygotic lethal gene pha-1 affect a late step during organ development in the nematode C. elegans [2].
• The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18 [3].

Biological context of pha-1

• During embryogenesis a transgenic pha-1 reporter construct is expressed transiently in all pharynx precursor cells at the time when these cells become restricted to form the pharynx organ [2].
• We have not noted a phenotype distinguishing any of the suppressors from wild type except for suppression of pha-1 [4].

Other interactions of pha-1

• We also examine the relationship between ceh-22 and the pharyngeal organ-specific differentiation gene pha-1 [1].

References