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Gene Review

pha-1  -  Protein PHA-1

Caenorhabditis elegans

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High impact information on pha-1


Biological context of pha-1

  • During embryogenesis a transgenic pha-1 reporter construct is expressed transiently in all pharynx precursor cells at the time when these cells become restricted to form the pharynx organ [2].
  • We have not noted a phenotype distinguishing any of the suppressors from wild type except for suppression of pha-1 [4].

Other interactions of pha-1

  • We also examine the relationship between ceh-22 and the pharyngeal organ-specific differentiation gene pha-1 [1].


  1. The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development. Okkema, P.G., Ha, E., Haun, C., Chen, W., Fire, A. Development (1997) [Pubmed]
  2. Genesis of an organ: molecular analysis of the pha-1 gene. Granato, M., Schnabel, H., Schnabel, R. Development (1994) [Pubmed]
  3. The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18. Fay, D.S., Qiu, X., Large, E., Smith, C.P., Mango, S., Johanson, B.L. Dev. Biol. (2004) [Pubmed]
  4. Suppressors of the organ-specific differentiation gene pha-1 of Caenorhabditis elegans. Schnabel, H., Bauer, G., Schnabel, R. Genetics (1991) [Pubmed]
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