Disease relevance of Bartonella Infections

• The gene encoding this antigen (7B2) was isolated from an expression library made directly from randomly generated fragments of B. bacilliformis genomic DNA using Bartonella antibodies raised in rabbits and sera of bartonellosis patients [1].
• Cat scratch disease (bartonellosis) mimicking an SLE flare [2].
• Sera investigated for cross-reaction with these diagnostic antigens were drawn from patients with brucellosis, chlamydiosis, Q fever, and cat scratch disease, all of whom were from regions where bartonellosis is not endemic [3].

High impact information on Bartonella Infections

• Surprisingly, the major source of VEGF production in verruga peruana is the overlying epidermis [4].
• High-level expression of angiopoietin-2 and VEGF receptors was observed in the endothelium of verruga peruana [4].
• In modern Peru, symptomatic patients who have acute-phase bartonellosis typically present with a febrile illness and systemic symptoms caused by profound anemia; most patients respond successfully to treatment with chloramphenicol [5].
• We examined the cases of 145 symptomatic patients in Lima, Peru, in whom bartonellosis was diagnosed from 1969 through 1992, including 68 patients in the acute (hematic) phase and 77 patients in the eruptive (verruga) phase [5].
• When used to examine convalescent-phase sera, the IFA is positive in 93% of bartonellosis cases [6].

Chemical compound and disease context of Bartonella Infections

• For identification of Oroya fever patients in the field, an eosin/thiazine stain of blood smears was found to be appropriate [7].

Analytical, diagnostic and therapeutic context of Bartonella Infections

• Twelve antigens were detected by antibodies in sera of bartonellosis patients using immunoblot, of which six antigens were detected by immunoprecipitation [8].
• When applied to enzyme immunoassays, Bb65 sensitively and specifically bound to IgG antibody of sera of bartonellosis patients, convalescents, and immunes from various Peruvian regions [1].

References