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Disease relevance of Vitiligo


High impact information on Vitiligo

  • One of the mildest of these is the Mitf vitiligo (Mitfvit) mutant allele, which exhibits uneven pigmentation of the retinal pigment epithelium (RPE) and slow, progressive photoreceptor cell loss, eventually leading to blindness [3].
  • OBJECTIVE: To develop and apply a simple clinical tool, the Vitiligo Area Scoring Index (VASI), to model the response of vitiligo to narrowband UV-B (NB-UV-B) phototherapy using parametric tests [4].
  • Facial and truncal poliosis and vitiligo were also evident; skin biopsy specimens were obtained from the nasal planum [5].
  • The abnormal urinary indole profile induced by hydroquinone has been found to be reversed by psoralene, a pigmentogenic drug in vitiligo [6].
  • CONCLUSION: ET-1 may influence the adhesion and migration of melanocyte, which can partly explain the capacity of ET-1 to regulate the melanocyte function in vitiligo lesions [7].

Chemical compound and disease context of Vitiligo

  • The effect of 5-Azacytidine (5-AzaC) on melanization was examined in two sublines of the Smyth line (SL) chicken model for autoimmune vitiligo, in two MHC-matched vitiligo-susceptible but normally pigmented controls (BL), and in nonsusceptible controls (LBL) [8].

Anatomical context of Vitiligo

  • Smyth line (SL) chickens, which develop a depigmenting disorder similar to human vitiligo, produce circulating anti-melanocyte antibodies (Austin, L.M. et al., (1992) The detection of melanocyte autoantibodies in the Smyth chicken model for vitiligo. Clin. Immunol. Immunopathol., 64:112-120) [9].


  1. Apparent exacerbation of vitiligo syndrome in a patient with pulmonary Mycobacterium avium complex disease who received clofazimine therapy. Brown-Harrell, V., Nitta, A.T., Goble, M. Clin. Infect. Dis. (1996) [Pubmed]
  2. Intrinsic and extrinsic pathomechanisms in vitiligo. Taïeb, A. Pigment Cell Res. (2000) [Pubmed]
  3. Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice. Bora, N., Conway, S.J., Liang, H., Smith, S.B. Dev. Dyn. (1998) [Pubmed]
  4. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Hamzavi, I., Jain, H., McLean, D., Shapiro, J., Zeng, H., Lui, H. Archives of dermatology. (2004) [Pubmed]
  5. Unilateral uveitis in a dog with uveodermatologic syndrome. Sigle, K.J., McLellan, G.J., Haynes, J.S., Myers, R.K., Betts, D.M. J. Am. Vet. Med. Assoc. (2006) [Pubmed]
  6. Urinary indole profile of Bufo melanostictus during hydroquinone-induced leucoderma and its regeneration. Chakraborty, D.P., Chatterjee, A. Clin. Chim. Acta (1977) [Pubmed]
  7. Effects of endothelin-1 on melanocyte adhesion and migration. Mou, K.H., Zhang, X.Q., Yu, B., Zhang, Z.L., Feng, J. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. (2004) [Pubmed]
  8. 5-azacytidine treatment induces autoimmune vitiligo in parental control strains of the Smyth line chicken model for autoimmune vitiligo. Sreekumar, G.P., Erf, G.F., Smyth, J.R. Clin. Immunol. Immunopathol. (1996) [Pubmed]
  9. Smyth chicken melanocyte autoantibodies: cross-species recognition, in vivo binding, and plasma membrane reactivity of the antiserum. Searle, E.A., Austin, L.M., Boissy, Y.L., Zhao, H., Nordlund, J.J., Boissy, R.E. Pigment Cell Res. (1993) [Pubmed]
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