High impact information on Mental Fatigue

• Increases in brain 5-HT concentration and overall activity have been associated with increased physical and perhaps mental fatigue during endurance exercise [1].
• Self-rated mental fatigue was reduced and ratings of alertness were significantly improved by caffeine independent of group [2].
• Somatic fatigue was worst in RA, while mental fatigue was worst in PSS and SLE [3].
• It was concluded that ACTH 4-10 counteracts the usual decay in performance as a function of time-on-task due to increasing boredom and mental fatigue [4].
• The 10 min battery comprised a Serial Threes subtraction task (2 min); a Serial Sevens task (2 min); a Rapid Visual Information Processing task (5 min); then a 'mental fatigue' visual analogue scale [5].

Chemical compound and disease context of Mental Fatigue

• Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation [6].
• Wessely and Powell scores decreased significantly by 40% (physical fatigue) and 45% (mental fatigue) in subjects taking levocarnitine, compared with 11% and 8%, respectively, in the placebo group (p < 0.001 vs placebo for both parameters) [7].
• However, more experiments are needed to further clarify the effect of BCAA and also of tryptophan ingestion on physical performance and mental fatigue [8].
• When cellular energy decreases the glutamate transmission decreases, and according to our hypothesis, this is one cause of mental fatigue [9].
• Acetylcarnitine significantly improved mental fatigue (p =.015) and propionylcarnitine improved general fatigue (p =.004) [10].

Gene context of Mental Fatigue

• Effects of mental fatigue on attention: an ERP study [11].
• The results indicate that ingestion of BCAA reduces the perceived exertion and mental fatigue during exercise and improves cognitive performance after the exercise [8].
• Every 10 min during exercise the subjects rated their perceived exertion and mental fatigue on two different Borg scales [12].
• Through above examinations, FDP values of serum and urine seem to be useful as an index of transient fatigue; especially they can well reflect mental fatigue which cannot be indicated well by other biochemical indices [13].

Analytical, diagnostic and therapeutic context of Mental Fatigue

• Hence, oral administration of branched chain amino acids could, theoretically, prevent the increase in 5-HT level during exercise and therefore delay physical and mental fatigue [14].

References