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Chemical Compound Review

Oraconal     [(8R,9S,10R,13S,14S,17R)-17- ethanoyl-6,10...

Synonyms: Menoquens, Nuvacon, Kombiquens, Megethinyl, Serial, ...
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Disease relevance of Nuvacon


Psychiatry related information on Nuvacon

  • Reevaluation of the ultrastructural pathology of experimental Creutzfeldt-Jakob disease. Serial studies of the Fujisaki strain of Creutzfeldt-Jakob disease virus in mice [6].
  • OBJECTIVE: Serial registered MRI provides a reproducible technique for detecting progressive cerebral atrophy in vivo and was used to determine if there were differences between the rates of cerebral atrophy in AD and frontotemporal dementia (FTD) [7].
  • METHODS: Serial salivary cortisol samples were examined in 98 subjects (ages 9-17 years), including 62 subjects with an anxiety and/or mood disorder and 36 nonpsychiatrically ill comparisons [8].
  • The IPV subjects, regardless of PTSD status, had poorer performance on tasks of speeded, sustained auditory attention and working memory (Paced Auditory Serial Addition Test) and response inhibition (Stroop) [9].
  • The Serial Reaction Time test requires the development of sequential learning and little (if any) procedural learning, whereas the Mirror Drawing test involves fast and repetitive processing of visuospatial stimuli but no acquisition of sequences [10].

High impact information on Nuvacon


Chemical compound and disease context of Nuvacon


Biological context of Nuvacon


Anatomical context of Nuvacon

  • Reduced activation in patients was not confined to the inferior frontal gyrus, but also extended to a medial area during the Tone Serial Position Task and to premotor and anterior temporal lobe areas during both tasks [26].
  • Role of compensatory enlargement and shrinkage in transplant coronary artery disease. Serial intravascular ultrasound study [27].
  • Within individual mitochondria, the cristae become locally rearranged in a pattern that we have termed a "swirl." Serial sections through individual mitochondria reveal the reorganization of the cristae in three dimensions [28].
  • How does angioplasty work? Serial analysis of human iliac arteries using intravascular ultrasound [29].
  • We used the Serial Analysis of Gene Expression (SAGE) database to identify differences between solid tumors and cell lines, hoping to detect genes that could potentially explain differences in drug sensitivity [30].

Associations of Nuvacon with other chemical compounds


Gene context of Nuvacon

  • Using the National Center for Biotechnology Information Serial Analysis of Gene Expression database, we found that S100A4, a calcium-binding protein previously implicated in metastasis, was expressed in five of seven pancreatic carcinoma libraries but not in the two normal pancreatic duct libraries [36].
  • METHODS: Serial immunohistochemical staining for CXCL13, CXCR5, and CD20 was carried out in protocol biopsies of 23 patients obtained between day 4 and day 9 after renal transplantation [37].
  • MEASUREMENTS AND MAIN RESULTS: Serial serum samples were collected for analysis of concentrations of PCT, SAA, and CRP [38].
  • RESULTS: Serial weekly intraperitoneal administrations of escalating doses of rmIFN-gamma did not affect peripheral blood counts in FANCC(-/-) mice, even after subsequent antibody-mediated fas ligation [39].
  • (a) Serial sections were either incubated with anti-CA IV/FITC or processed for endothelial ATPase reaction [40].

Analytical, diagnostic and therapeutic context of Nuvacon


  1. Incidence of left-ventricular thrombosis after acute transmural myocardial infarction. Serial evaluation by two-dimensional echocardiography. Asinger, R.W., Mikell, F.L., Elsperger, J., Hodges, M. N. Engl. J. Med. (1981) [Pubmed]
  2. Loss of tumor marker-immunostaining intensity on stored paraffin slides of breast cancer. Jacobs, T.W., Prioleau, J.E., Stillman, I.E., Schnitt, S.J. J. Natl. Cancer Inst. (1996) [Pubmed]
  3. Constitutive variability in the pharmacokinetics of the natural retinoid, all-trans-retinoic acid, and its modulation by ketoconazole. Rigas, J.R., Francis, P.A., Muindi, J.R., Kris, M.G., Huselton, C., DeGrazia, F., Orazem, J.P., Young, C.W., Warrell, R.P. J. Natl. Cancer Inst. (1993) [Pubmed]
  4. A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia. van Baal, J.W., Milano, F., Rygiel, A.M., Bergman, J.J., Rosmolen, W.D., van Deventer, S.J., Wang, K.K., Peppelenbosch, M.P., Krishnadath, K.K. Gastroenterology (2005) [Pubmed]
  5. HIV-1 suppression during acute scrub-typhus infection. Watt, G., Kantipong, P., de Souza, M., Chanbancherd, P., Jongsakul, K., Ruangweerayud, R., Loomis-Price, L.D., Polonis, V., Myint, K.S., Birx, D.L., Brown, A.E., Krishna, S. Lancet (2000) [Pubmed]
  6. Reevaluation of the ultrastructural pathology of experimental Creutzfeldt-Jakob disease. Serial studies of the Fujisaki strain of Creutzfeldt-Jakob disease virus in mice. Liberski, P.P., Yanagihara, R., Asher, D.M., Gibbs, C.J., Gajdusek, D.C. Brain (1990) [Pubmed]
  7. Rates of global and regional cerebral atrophy in AD and frontotemporal dementia. Chan, D., Fox, N.C., Jenkins, R., Scahill, R.I., Crum, W.R., Rossor, M.N. Neurology (2001) [Pubmed]
  8. Salivary cortisol concentrations before and after carbon-dioxide inhalations in children. Coplan, J.D., Moreau, D., Chaput, F., Martinez, J.M., Hoven, C.W., Mandell, D.J., Gorman, J.M., Pine, D.S. Biol. Psychiatry (2002) [Pubmed]
  9. Neuropsychological function in female victims of intimate partner violence with and without posttraumatic stress disorder. Stein, M.B., Kennedy, C.M., Twamley, E.W. Biol. Psychiatry (2002) [Pubmed]
  10. Do children with developmental dyslexia have an implicit learning deficit? Vicari, S., Finzi, A., Menghini, D., Marotta, L., Baldi, S., Petrosini, L. J. Neurol. Neurosurg. Psychiatr. (2005) [Pubmed]
  11. T-cell receptors. Serial engagement proposed. Davis, M.M. Nature (1995) [Pubmed]
  12. Hypercalcemia due to endogenous overproduction of active vitamin D in identical twins with cat-scratch disease. Bosch, X. JAMA (1998) [Pubmed]
  13. Doxorubicin cardiotoxicity. Serial endomyocardial biopsies and systolic time intervals. Friedman, M.A., Bozdech, M.J., Billingham, M.E., Rider, A.K. JAMA (1978) [Pubmed]
  14. 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Dubinsky, M.C., Yang, H., Hassard, P.V., Seidman, E.G., Kam, L.Y., Abreu, M.T., Targan, S.R., Vasiliauskas, E.A. Gastroenterology (2002) [Pubmed]
  15. Platelet activation in acute cerebral ischaemia. Serial measurements of platelet function in cerebrovascular disease. Dougherty, J.H., Levy, D.E., Weksler, B.B. Lancet (1977) [Pubmed]
  16. Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. Lipshultz, S.E., Lipsitz, S.R., Sallan, S.E., Dalton, V.M., Mone, S.M., Gelber, R.D., Colan, S.D. J. Clin. Oncol. (2005) [Pubmed]
  17. Hyperinsulinemia during oral glucose tolerance test is associated with increased neointimal tissue proliferation after coronary stent implantation in nondiabetic patients: a serial intravascular ultrasound study. Takagi, T., Yoshida, K., Akasaka, T., Kaji, S., Kawamoto, T., Honda, Y., Yamamuro, A., Hozumi, T., Morioka, S. J. Am. Coll. Cardiol. (2000) [Pubmed]
  18. Early noninvasive identification of failed reperfusion after intravenous thrombolytic therapy in acute myocardial infarction. Stewart, J.T., French, J.K., Théroux, P., Ramanathan, K., Solymoss, B.C., Johnson, R., White, H.D. J. Am. Coll. Cardiol. (1998) [Pubmed]
  19. Benign Myoclonic Epilepsy in Infancy (BMEI): A Longitudinal Electroclinical Study of 22 Cases. Darra, F., Fiorini, E., Zoccante, L., Mastella, L., Torniero, C., Cortese, S., Meneghello, L., Fontana, E., Bernardina, B.D. Epilepsia (2006) [Pubmed]
  20. Pharmacokinetic and pharmacodynamic assessment of co-amoxiclav in the treatment of melioidosis. Chierakul, W., Wangboonskul, J., Singtoroj, T., Pongtavornpinyo, W., Short, J.M., Maharjan, B., Wuthiekanun, V., Dance, D.A., Teparrukkul, P., Lindegardh, N., Peacock, S.J., Day, N.P., Chaowagul, W., White, N.J. J. Antimicrob. Chemother. (2006) [Pubmed]
  21. Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitis. White, B., Moore, W.C., Wigley, F.M., Xiao, H.Q., Wise, R.A. Ann. Intern. Med. (2000) [Pubmed]
  22. Control mechanisms for physiological hypertrophy of pregnancy. Mone, S.M., Sanders, S.P., Colan, S.D. Circulation (1996) [Pubmed]
  23. Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy? Bader, P., Kreyenberg, H., Hoelle, W., Dueckers, G., Handgretinger, R., Lang, P., Kremens, B., Dilloo, D., Sykora, K.W., Schrappe, M., Niemeyer, C., Von Stackelberg, A., Gruhn, B., Henze, G., Greil, J., Niethammer, D., Dietz, K., Beck, J.F., Klingebiel, T. J. Clin. Oncol. (2004) [Pubmed]
  24. Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma. Stoecklein, N.H., Luebke, A.M., Erbersdobler, A., Knoefel, W.T., Schraut, W., Verde, P.E., Stern, F., Scheunemann, P., Peiper, M., Eisenberger, C.F., Izbicki, J.R., Klein, C.A., Hosch, S.B. J. Clin. Oncol. (2004) [Pubmed]
  25. Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect. Childs, R.W., Clave, E., Tisdale, J., Plante, M., Hensel, N., Barrett, J. J. Clin. Oncol. (1999) [Pubmed]
  26. Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Stevens, A.A., Goldman-Rakic, P.S., Gore, J.C., Fulbright, R.K., Wexler, B.E. Arch. Gen. Psychiatry (1998) [Pubmed]
  27. Role of compensatory enlargement and shrinkage in transplant coronary artery disease. Serial intravascular ultrasound study. Lim, T.T., Liang, D.H., Botas, J., Schroeder, J.S., Oesterle, S.N., Yeung, A.C. Circulation (1997) [Pubmed]
  28. Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl. Walker, D.W., Benzer, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  29. How does angioplasty work? Serial analysis of human iliac arteries using intravascular ultrasound. Losordo, D.W., Rosenfield, K., Pieczek, A., Baker, K., Harding, M., Isner, J.M. Circulation (1992) [Pubmed]
  30. A Serial Analysis of Gene Expression (SAGE) database analysis of chemosensitivity: comparing solid tumors with cell lines and comparing solid tumors from different tissue origins. Stein, W.D., Litman, T., Fojo, T., Bates, S.E. Cancer Res. (2004) [Pubmed]
  31. Prospective serial evaluation of myocardial perfusion and lipids during the first six months of pravastatin therapy: coronary artery disease regression single photon emission computed tomography monitoring trial. Schwartz, R.G., Pearson, T.A., Kalaria, V.G., Mackin, M.L., Williford, D.J., Awasthi, A., Shah, A., Rains, A., Guido, J.J. J. Am. Coll. Cardiol. (2003) [Pubmed]
  32. Impact of pregnancy on abacavir pharmacokinetics. Best, B.M., Mirochnick, M., Capparelli, E.V., Stek, A., Burchett, S.K., Holland, D.T., Read, J.S., Smith, E., Hu, C., Spector, S.A., Connor, J.D. AIDS (2006) [Pubmed]
  33. Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: a serial intravascular ultrasound study. Takagi, T., Akasaka, T., Yamamuro, A., Honda, Y., Hozumi, T., Morioka, S., Yoshida, K. J. Am. Coll. Cardiol. (2000) [Pubmed]
  34. Plasma and cerebrospinal fluid pharmacokinetics of intravenous oxaliplatin, cisplatin, and carboplatin in nonhuman primates. Jacobs, S.S., Fox, E., Dennie, C., Morgan, L.B., McCully, C.L., Balis, F.M. Clin. Cancer Res. (2005) [Pubmed]
  35. Effects of CYP3A inhibition on the metabolism of cilostazol. Suri, A., Forbes, W.P., Bramer, S.L. Clinical pharmacokinetics. (1999) [Pubmed]
  36. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Rosty, C., Ueki, T., Argani, P., Jansen, M., Yeo, C.J., Cameron, J.L., Hruban, R.H., Goggins, M. Am. J. Pathol. (2002) [Pubmed]
  37. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection. Steinmetz, O.M., Panzer, U., Kneissler, U., Harendza, S., Lipp, M., Helmchen, U., Stahl, R.A. Kidney Int. (2005) [Pubmed]
  38. Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro. Nijsten, M.W., Olinga, P., The, T.H., de Vries, E.G., Koops, H.S., Groothuis, G.M., Limburg, P.C., ten Duis, H.J., Moshage, H., Hoekstra, H.J., Bijzet, J., Zwaveling, J.H. Crit. Care Med. (2000) [Pubmed]
  39. In vivo administration of interferon gamma does not cause marrow aplasia in mice with a targeted disruption of FANCC. Kurre, P., Anandakumar, P., Grompe, M., Kiem, H.P. Exp. Hematol. (2002) [Pubmed]
  40. Immunohistochemical localization of carbonic anhydrase IV in capillaries of rat and human skeletal muscle. Sender, S., Gros, G., Waheed, A., Hageman, G.S., Sly, W.S. J. Histochem. Cytochem. (1994) [Pubmed]
  41. Human ehrlichiosis in adults after tick exposure. Diagnosis using polymerase chain reaction. Everett, E.D., Evans, K.A., Henry, R.B., McDonald, G. Ann. Intern. Med. (1994) [Pubmed]
  42. Serial follow-up after optimized ultrasound-guided deployment of Palmaz-Schatz stents. In-stent neointimal proliferation without significant reference segment response. Mudra, H., Regar, E., Klauss, V., Werner, F., Henneke, K.H., Sbarouni, E., Theisen, K. Circulation (1997) [Pubmed]
  43. Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study. Mintz, G.S., Popma, J.J., Pichard, A.D., Kent, K.M., Satler, L.F., Wong, C., Hong, M.K., Kovach, J.A., Leon, M.B. Circulation (1996) [Pubmed]
  44. Cardioversion of nonrheumatic atrial fibrillation. Reduced thromboembolic complications with 4 weeks of precardioversion anticoagulation are related to atrial thrombus resolution. Collins, L.J., Silverman, D.I., Douglas, P.S., Manning, W.J. Circulation (1995) [Pubmed]
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