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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Type A Personality

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Disease relevance of Type A Personality

  • Hispanics had lower serum uric acid levels and greater central obesity than Anglos; they were less likely to have a Type A personality, less physically active at work, and more likely to be a current smoker than Anglos [1].

Psychiatry related information on Type A Personality


High impact information on Type A Personality

  • If decreases in HDL are not in the same causal pathway, then the apparent association between type A personality and risk of MI is due to confounding, principally by HDL [3].
  • Although debrisoquine hydroxylase (CYP2D6) capacity has been associated with personality, no study has specifically investigated its association with personality Type A and B. Therefore the aim of this research was to study the impact of CYP2D6 on Type A and B personality [4].
  • A factor analysis identified seven factors related to personality traits; the three most important were hardiness, positive affect/optimism and Type A personality [5].
  • The association between the total theta power change and "calm" score was found to be insignificant if the type-A personality variable was added to their regression model [6].
  • Type A personality may strike at the heart of CAD [7].

Chemical compound and disease context of Type A Personality


Gene context of Type A Personality

  • This suggests the possibility of a 'hypertensive coronary-prone personality'. Because of their excellent antihypertensive response to chronic beta-blocker therapy, it is conceivable that high renin patients benefit most from the cardioprotective potential of beta-blocker-based antihypertensive therapy [9].


  1. Cardiovascular risk factors and impaired glucose tolerance: the San Luis Valley Diabetes Study. Burchfiel, C.M., Hamman, R.F., Marshall, J.A., Baxter, J., Kahn, L.B., Amirani, J.J. Am. J. Epidemiol. (1990) [Pubmed]
  2. Multiple risk factors for coronary artery disease: behavioral factors in preventive cardiology. Pearson, T.A. Am. J. Cardiol. (1987) [Pubmed]
  3. Psychosocial risk factors and nonfatal myocardial infarction. O'Connor, N.J., Manson, J.E., O'Connor, G.T., Buring, J.E. Circulation (1995) [Pubmed]
  4. Relationship between Type A and B personality and debrisoquine hydroxylation capacity. Gan, S.H., Ismail, R., Wan Adnan, W.A., Zulmi, W., Kumaraswamy, N., Larmie, E.T. British journal of clinical pharmacology. (2004) [Pubmed]
  5. Self-rated health among university students in relation to sense of coherence and other personality traits. von Bothmer, M.I., Fridlund, B. Scandinavian journal of caring sciences. (2003) [Pubmed]
  6. EEG power spectrum changes due to listening to pleasant music and their relation to relaxation effects. Kabuto, M., Kageyama, T., Nitta, H. Nippon eiseigaku zasshi. Japanese journal of hygiene. (1993) [Pubmed]
  7. Type A personality may strike at the heart of CAD. Allen, T.W. The Journal of the American Osteopathic Association. (1992) [Pubmed]
  8. Anxiety, type A personality and endocrine responses to surgery. Salmon, P., Pearce, S., Smith, C.C., Manyande, A., Heys, A., Peters, N., Rashid, J. The British journal of clinical psychology / the British Psychological Society. (1989) [Pubmed]
  9. Personality, coronary-prone behaviour and adrenergic factors in essential hypertension: possible implications for cardiac prevention. Perini, C., Müller, F., Bühler, F.R. Activitas nervosa superior. (1982) [Pubmed]
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