Disease relevance of A Factor

• A factor discriminating between the wild-type and a mutant polyomavirus enhancer [1].
• A factor prsent in uterine flushings of gilts stimulates the conversion of highly pruified boar proacrosin to acrosin [2].
• A factor that promotes the growth of certain B cell hybridomas and of plasmacytomas is shown to be produced by normal human fibroblasts and by a line of human osteosarcoma cells (MG-63) after treatment with IL-1 or TNF [3].
• METHODS: A factor-based area socioeconomic index was linked to 1950-1998 county mortality data to generate annual lung and colorectal cancer mortality rates for each area socioeconomic group [4].
• A factor controlling the extent of development of inherited melanomas was demonstrated to be associated only with LG V loci, implying predominant control by a single gene, which probably determines the completeness of differentiation of macromelanophores in hybrids [5].

Psychiatry related information on A Factor

• A factor analysis showed impairments in power of concentration and speed of working memory, independent of a history of intravenous drug usage (IVDU), depression, fatigue, or symptom severity [6].
• A factor analysis of depressive symptoms from the group was performed to derive a depression severity score [7].
• A factor analysis of tic symptoms in Gilles de la Tourette's syndrome [8].
• A factor analytic approach used with the Hamilton depression scores showed that depressive retardation symptoms were the most responsive to sleep deprivation in the premenstrual dysphoric disorder subjects [9].
• A factor analysis of the entire item set of the DSM-III criteria was conducted to determine the extent to which the factors that emerged corresponded to the 11 personality disorders and three clusters included in DSM-III [10].

High impact information on A Factor

• A factor in conditioned medium from B. subtilis cells engineered to produce SpollR during growth triggered processing in protoplasts of B. subtilis cells that had been engineered to produce SpollGA and pro-sigma E [11].
• A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly [12].
• This factor is required for active transcription of an hsp 70 gene in addition to RNA polymerase II and another general transcription factor, the A factor [13].
• A factor, RF-S, was partially purified from human S phase cells based on its ability to activate DNA replication in extracts from G1 cells [14].
• The mutant is also defective in the production of A-factor, an early extracellular cell-density signal [15].

Chemical compound and disease context of A Factor

• The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor [16].
• Hemolytic Uremic Syndrome: A Factor H Mutation (E1172Stop) Causes Defective Complement Control at the Surface of Endothelial Cells [17].
• The nucleotide sequence of afsB from Streptomyces coelicolor A3(2), a pleiotropic gene which positively controls the biosynthesis of A-factor and the pigmented antibiotics actinorhodin and undecylprodigiosin in S. coelicolor A3(2) and "Streptomyces lividans," was determined [18].
• Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-Ar [19].
• Maternal thiamine deficiency. A factor in intrauterine growth retardation [20].

Biological context of A Factor

• A factor X peptide duplicating the inter-EGF sequence Leu83-Leu88-(Gly) blocked the binding of 125I-factor Xa to these cells in a dose-dependent manner (IC50 = 110+/-21 nM) [21].
• A factor fundamental to bone formation has been identified [22].
• A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli [23].
• A factor with apparently indistinguishable sequence specificity can be induced in many other cell types, where it is used to regulate inducible gene expression [24].
• A factor, present in transcriptionally active extracts prepared from purified vaccinia virus particles, binds to vaccinia early promoter sequences [25].

Anatomical context of A Factor

• A factor able to induce an early local inflammation in rabbit skin was detected in the supernatant of mitogen-stimulated human blood leukocytes [26].
• A factor from plasma-derived human serum that inhibits the growth of the mammary cell line MCF-7: characterization and purification [27].
• A factor with chemotactic properties for neutrophils and mononuclear cells was extracted from the lysosomal fraction of both human and rabbit neutrophils that had been allowed to phagocytose monosodium urate crystals [28].
• A factor produced by monocytes that affects osteoblast activity may be important in the coupling of osteoclast and osteoblast actions [29].
• A factor from neurons induces partial immobilization of nonclustered acetylcholine receptors on cultured muscle cells [30].

Associations of A Factor with other chemical compounds

• In the signal relay leading to streptomycin production in S. griseus, the A-factor signal is transferred from the A-factor receptor to the upstream activation sequence of a regulatory gene, strR, in the streptomycin biosynthetic gene cluster via an A-factor-dependent protein that serves as a transcription factor for strR [31].
• This glycoprotein present in plasma is involved in platelet adhesion at the site of vascular injury and serves as the carrier of antihaemophilic A factor (FVIII) [32].
• A factor isolated from rabbit reticulocyte white ghosts by Triton X-100 treatment blocks protein synthesis at the elongation-termination stage [33].
• Though butalactin is structurally related to 'signal molecules' such as A-factor, the anthracycline inducing factors and the virginiae butanolides, it does not show inducing activity for antibiotic production or aerial mycelium formation in the indicator strain [34].
• (1) A factor analysis identified two factors that describe an involvement/commitment dimension (Factor 1) and a positive/negative change dimension (Factor 2) [35].

Gene context of A Factor

• A factor was found which inhibited the IL-2-induced proliferation of mitogen-stimulated human T cells and the IL-1-induced proliferation of C3H/Hej mouse thymocytes, but not IL-1-induced fibroblast proliferation [36].
• A factor of inducing IgE from a filarial parasite is an agonist of human CD40 [37].
• A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt [38].
• A factor stimulating transcription of the testis-specific Pgk-2 gene recognizes a sequence similar to the binding site for a transcription inhibitor of the somatic-type Pgk-1 gene [39].
• A factor binding to the B-myb CHR was identified in fractionated HeLa nuclear extract and found to interact with the minor groove, as previously shown by in vivo footprinting for the cyclin A CHR [40].

Analytical, diagnostic and therapeutic context of A Factor

• A factor that bound to the ABRE in electrophoretic mobility shift assays was present at the same developmental stages as rab28 mRNA and had binding characteristics similar to those observed by in vivo footprinting [41].
• A factor IX-deficient mouse model for hemophilia B gene therapy [42].
• A factor complicating vaccination is that different bacterial strains produce distinct, and sometimes highly divergent, pilin variants [43].
• A factor in serum was found to produce cholestatic changes in the bile flow of rats on intravenous infusion [44].
• A factor in goat's colostrum which stimulates DNA synthesis and cell proliferation in Swiss 3T3 fibroblasts has been purified approx. 350-fold by a sequence of acid precipitation, cation-exchange chromatography and gel filtration [45].

References