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Chemical Compound Review

A-Factor     (4R)-4-(hydroxymethyl)-3-(6...

Synonyms: A Factor, SureCN6026457, CHEBI:73982, CPD-10135, AR-1C7319, ...
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Disease relevance of A Factor


Psychiatry related information on A Factor

  • A factor analysis showed impairments in power of concentration and speed of working memory, independent of a history of intravenous drug usage (IVDU), depression, fatigue, or symptom severity [6].
  • A factor analysis of depressive symptoms from the group was performed to derive a depression severity score [7].
  • A factor analysis of tic symptoms in Gilles de la Tourette's syndrome [8].
  • A factor analytic approach used with the Hamilton depression scores showed that depressive retardation symptoms were the most responsive to sleep deprivation in the premenstrual dysphoric disorder subjects [9].
  • A factor analysis of the entire item set of the DSM-III criteria was conducted to determine the extent to which the factors that emerged corresponded to the 11 personality disorders and three clusters included in DSM-III [10].

High impact information on A Factor

  • A factor in conditioned medium from B. subtilis cells engineered to produce SpollR during growth triggered processing in protoplasts of B. subtilis cells that had been engineered to produce SpollGA and pro-sigma E [11].
  • A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly [12].
  • This factor is required for active transcription of an hsp 70 gene in addition to RNA polymerase II and another general transcription factor, the A factor [13].
  • A factor, RF-S, was partially purified from human S phase cells based on its ability to activate DNA replication in extracts from G1 cells [14].
  • The mutant is also defective in the production of A-factor, an early extracellular cell-density signal [15].

Chemical compound and disease context of A Factor


Biological context of A Factor


Anatomical context of A Factor


Associations of A Factor with other chemical compounds

  • In the signal relay leading to streptomycin production in S. griseus, the A-factor signal is transferred from the A-factor receptor to the upstream activation sequence of a regulatory gene, strR, in the streptomycin biosynthetic gene cluster via an A-factor-dependent protein that serves as a transcription factor for strR [31].
  • This glycoprotein present in plasma is involved in platelet adhesion at the site of vascular injury and serves as the carrier of antihaemophilic A factor (FVIII) [32].
  • A factor isolated from rabbit reticulocyte white ghosts by Triton X-100 treatment blocks protein synthesis at the elongation-termination stage [33].
  • Though butalactin is structurally related to 'signal molecules' such as A-factor, the anthracycline inducing factors and the virginiae butanolides, it does not show inducing activity for antibiotic production or aerial mycelium formation in the indicator strain [34].
  • (1) A factor analysis identified two factors that describe an involvement/commitment dimension (Factor 1) and a positive/negative change dimension (Factor 2) [35].

Gene context of A Factor

  • A factor was found which inhibited the IL-2-induced proliferation of mitogen-stimulated human T cells and the IL-1-induced proliferation of C3H/Hej mouse thymocytes, but not IL-1-induced fibroblast proliferation [36].
  • A factor of inducing IgE from a filarial parasite is an agonist of human CD40 [37].
  • A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt [38].
  • A factor stimulating transcription of the testis-specific Pgk-2 gene recognizes a sequence similar to the binding site for a transcription inhibitor of the somatic-type Pgk-1 gene [39].
  • A factor binding to the B-myb CHR was identified in fractionated HeLa nuclear extract and found to interact with the minor groove, as previously shown by in vivo footprinting for the cyclin A CHR [40].

Analytical, diagnostic and therapeutic context of A Factor


  1. A factor discriminating between the wild-type and a mutant polyomavirus enhancer. Kovesdi, I., Satake, M., Furukawa, K., Reichel, R., Ito, Y., Nevins, J.R. Nature (1987) [Pubmed]
  2. Fertilization: a uterine glycosaminoglycan stimulates the conversion of sperm proacrosin to acrosin. Wincek, T.J., Parrish, R.F., Polakoski, K.L. Science (1979) [Pubmed]
  3. Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. Van Damme, J., Opdenakker, G., Simpson, R.J., Rubira, M.R., Cayphas, S., Vink, A., Billiau, A., Van Snick, J. J. Exp. Med. (1987) [Pubmed]
  4. Changing area socioeconomic patterns in U.S. cancer mortality, 1950-1998: Part II--Lung and colorectal cancers. Singh, G.K., Miller, B.A., Hankey, B.F. J. Natl. Cancer Inst. (2002) [Pubmed]
  5. Linkage group V of platyfishes and Swordtails of the genus Xiphophorus (Poeciliidae): linkage of loci for malate dehydrogenase-2 and esterase-1 and esterase-4 with a gene controlling the severity of hybrid melanomas. Morizot, D.C., Siciliano, M.J. J. Natl. Cancer Inst. (1983) [Pubmed]
  6. Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease. Forton, D.M., Thomas, H.C., Murphy, C.A., Allsop, J.M., Foster, G.R., Main, J., Wesnes, K.A., Taylor-Robinson, S.D. Hepatology (2002) [Pubmed]
  7. Modification of DSM-IV criteria for depressed preschool children. Luby, J.L., Mrakotsky, C., Heffelfinger, A., Brown, K., Hessler, M., Spitznagel, E. The American journal of psychiatry. (2003) [Pubmed]
  8. A factor analysis of tic symptoms in Gilles de la Tourette's syndrome. Alsobrook, J.P., Pauls, D.L. The American journal of psychiatry. (2002) [Pubmed]
  9. Early versus late partial sleep deprivation in patients with premenstrual dysphoric disorder and normal comparison subjects. Parry, B.L., Cover, H., Mostofi, N., LeVeau, B., Sependa, P.A., Resnick, A., Gillin, J.C. The American journal of psychiatry. (1995) [Pubmed]
  10. The factor structure of self-report DSM-III axis II symptoms and their relationship to clinicians' ratings. Hyler, S.E., Lyons, M., Rieder, R.O., Young, L., Williams, J.B., Spitzer, R.L. The American journal of psychiatry. (1990) [Pubmed]
  11. Extracellular signal protein triggering the proteolytic activation of a developmental transcription factor in B. subtilis. Hofmeister, A.E., Londoño-Vallejo, A., Harry, E., Stragier, P., Losick, R. Cell (1995) [Pubmed]
  12. A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly. Ruskin, B., Zamore, P.D., Green, M.R. Cell (1988) [Pubmed]
  13. A Drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene. Parker, C.S., Topol, J. Cell (1984) [Pubmed]
  14. Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase. D'Urso, G., Marraccino, R.L., Marshak, D.R., Roberts, J.M. Science (1990) [Pubmed]
  15. The guanosine nucleotide (p)ppGpp initiates development and A-factor production in myxococcus xanthus. Harris, B.Z., Kaiser, D., Singer, M. Genes Dev. (1998) [Pubmed]
  16. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor. Ohnishi, Y., Kameyama, S., Onaka, H., Horinouchi, S. Mol. Microbiol. (1999) [Pubmed]
  17. Hemolytic Uremic Syndrome: A Factor H Mutation (E1172Stop) Causes Defective Complement Control at the Surface of Endothelial Cells. Heinen, S., Józsi, M., Hartmann, A., Noris, M., Remuzzi, G., Skerka, C., Zipfel, P.F. J. Am. Soc. Nephrol. (2007) [Pubmed]
  18. Nucleotide sequence of afsB, a pleiotropic gene involved in secondary metabolism in Streptomyces coelicolor A3(2) and "Streptomyces lividans". Horinouchi, S., Suzuki, H., Beppu, T. J. Bacteriol. (1986) [Pubmed]
  19. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-Ar. Pittman, B., Gueorguieva, R., Krupitsky, E., Rudenko, A.A., Flannery, B.A., Krystal, J.H. Alcohol. Clin. Exp. Res. (2007) [Pubmed]
  20. Maternal thiamine deficiency. A factor in intrauterine growth retardation. Butterworth, R.F. Ann. N. Y. Acad. Sci. (1993) [Pubmed]
  21. Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo. Herbert, J., Bono, F., Herault, J., Avril, C., Dol, F., Mares, A., Schaeffer, P. J. Clin. Invest. (1998) [Pubmed]
  22. Cbfa1 in bone development. Komori, T., Kishimoto, T. Curr. Opin. Genet. Dev. (1998) [Pubmed]
  23. A factor that positively regulates cell division by activating transcription of the major cluster of essential cell division genes of Escherichia coli. Wang, X.D., de Boer, P.A., Rothfield, L.I. EMBO J. (1991) [Pubmed]
  24. Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene. Mauxion, F., Jamieson, C., Yoshida, M., Arai, K., Sen, R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  25. Early promoter-binding factor from vaccinia virions. Yuen, L., Davison, A.J., Moss, B. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  26. A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. Van Damme, J., Van Beeumen, J., Opdenakker, G., Billiau, A. J. Exp. Med. (1988) [Pubmed]
  27. A factor from plasma-derived human serum that inhibits the growth of the mammary cell line MCF-7: characterization and purification. Dell'Aquila, M.L., Pigott, D.A., Bonaquist, D.L., Gaffney, E.V. J. Natl. Cancer Inst. (1984) [Pubmed]
  28. Urate crystal-induced chemotactic factor: isolation and partial characterization. Spilbert, I., Gallacher, A., Mehta, J.M., Mandell, B. J. Clin. Invest. (1976) [Pubmed]
  29. Stimulation of the proliferation of human bone cells in vitro by human monocyte products with interleukin-1 activity. Gowen, M., Wood, D.D., Russell, R.G. J. Clin. Invest. (1985) [Pubmed]
  30. A factor from neurons induces partial immobilization of nonclustered acetylcholine receptors on cultured muscle cells. Axelrod, D., Bauer, H.C., Stya, M., Christian, C.N. J. Cell Biol. (1981) [Pubmed]
  31. A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus. Horinouchi, S., Beppu, T. Mol. Microbiol. (1994) [Pubmed]
  32. Estimation of the carbohydrate moiety of von Willebrand factor in the plasma of patients with subtypes 2a and 2b of von Willebrand disease. de Romeuf, C., Samor, B., Mazurier, C. Thromb. Haemost. (1995) [Pubmed]
  33. Interaction between membrane functions and protein synthesis in reticulocytes: specific cleavage of 28-S ribosomal RNA by a membrane constituent. Wreschner, D., Melloul, D., Herzberg, M. Eur. J. Biochem. (1978) [Pubmed]
  34. Butalactin, a new butanolide antibiotic. Taxonomy, fermentation, isolation and biological activity. Franco, C.M., Borde, U.P., Vijayakumar, E.K., Chatterjee, S., Blumbach, J., Ganguli, B.N. J. Antibiot. (1991) [Pubmed]
  35. A sociometric test to identify emergent leader and member roles: phase I. Brusa, J.A., Stone, M.H., Beck, A.P., Dugo, J.M., Peters, L.N. International journal of group psychotherapy. (1994) [Pubmed]
  36. Inhibitor of interleukin-2 in rheumatoid synovial fluid. Miossec, P., Kashiwado, T., Ziff, M. Arthritis Rheum. (1987) [Pubmed]
  37. A factor of inducing IgE from a filarial parasite is an agonist of human CD40. Imai, S., Tezuka, H., Furuhashi, Y., Muto, R., Fujita, K. J. Biol. Chem. (2001) [Pubmed]
  38. A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt. Matsushita, N., Sogawa, K., Ema, M., Yoshida, A., Fujii-Kuriyama, Y. J. Biol. Chem. (1993) [Pubmed]
  39. A factor stimulating transcription of the testis-specific Pgk-2 gene recognizes a sequence similar to the binding site for a transcription inhibitor of the somatic-type Pgk-1 gene. Goto, M., Masamune, Y., Nakanishi, Y. Nucleic Acids Res. (1993) [Pubmed]
  40. Cell cycle-regulated repression of B-myb transcription: cooperation of an E2F site with a contiguous corepressor element. Liu, N., Lucibello, F.C., Zwicker, J., Engeland, K., Müller, R. Nucleic Acids Res. (1996) [Pubmed]
  41. Protein binding to the abscisic acid-responsive element is independent of VIVIPAROUS1 in vivo. Busk, P.K., Pagès, M. Plant Cell (1997) [Pubmed]
  42. A factor IX-deficient mouse model for hemophilia B gene therapy. Wang, L., Zoppè, M., Hackeng, T.M., Griffin, J.H., Lee, K.F., Verma, I.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  43. Crystal structure of Pseudomonas aeruginosa PAK pilin suggests a main-chain-dominated mode of receptor binding. Hazes, B., Sastry, P.A., Hayakawa, K., Read, R.J., Irvin, R.T. J. Mol. Biol. (2000) [Pubmed]
  44. Hyperalimentation-associated jaundice: an example of a serum factor inducing cholestasis in rats. Latham, P.S., Menkes, E., Phillips, M.J., Jeejeebhoy, K.N. Am. J. Clin. Nutr. (1985) [Pubmed]
  45. Partial purification and characterization of a growth factor present in goat's colostrum. Similarities with platelet-derived growth factor. Brown, K.D., Blakeley, D.M. Biochem. J. (1984) [Pubmed]
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