High impact information on Hydrophidae

• Sequence analysis of a cDNA encoding a PLA2 from the sea-snake Aipysurus laevis [1].
• We recently showed that the only neurotoxin (a three-finger toxin) gene found in the sea snake A. eydouxii has a dinucleotide deletion, resulting in the loss of neurotoxic activity [2].
• The effect of tryptophan modification on the structure and function of a sea snake neurotoxin [3].
• We expressed functional nAChRs that contains segments or single residues of the Elapidae nAChR ligand binding domain and tested the effect of short-chain alpha-neurotoxin erabutoxin-a (ETX-a) from the Erabu sea snake Laticauda semifasciata on the acetylcholine-induced currents as measured by two-microelectrode voltage clamp [4].
• The method was applied to a study of erabutoxin b molecule, a neurotoxic protein from a sea snake, to analyze the microenvironments of its single tryptophan and tyrosine residues [5].

Biological context of Hydrophidae

• Comparative analysis of gene expression mechanisms between group IA and IB phospholipase A2 genes from sea snake Laticauda semifasciata [6].
• Amino acid sequence of the alpha- and beta-globin chains of the Erabu sea snake (Laticaudia semifasciata) [7].
• Two phospholipase A(2) (PLA(2)) genes classified into group IA were cloned from the genomic library of the sea snake Laticauda semifasciata [8].

Anatomical context of Hydrophidae

• Steroid synthesis in the adrenal gland of the sea snake Hydrophis cyanocinctus: the metabolism of exogenous precursors [9].

Associations of Hydrophidae with chemical compounds

• A major toxin was isolated from the venom of the sea snake Pelamis platurus (yellow-bellied sea snake) by Sephadex G-50 and carboxymethylcellulose column chromatography [10].
• 1. Erabutoxins, a, b and c, neurotoxic proteins of a sea snake Lacticauda semifasciata, were guanidinated with O-methylisourea [11].
• A 2.4-kb genomic clone, which encodes the precursor of a snake neurotoxin, erabutoxin c, was isolated from the liver of the sea snake, Laticauda semifasciata [12].
• Effect of Laticauda semifasciata (sea snake) venom on chloride transport across the frog skin [13].
• The amino groups of Laticauda semifasciata III (LsIII) purified from the venom of a sea snake, Laticauda semifasciata, were acetylated with acetic anhydride [14].

Gene context of Hydrophidae

• Since previous studies suggested the potential mobility of snoRNA genes during evolution, we propose that intron insertions or deletions of snoRNA genes occurred with the evolutionary divergence between the sea snake and land snake neurotoxins [15].
• Phylogenetic relationships of terrestrial Australo-Papuan elapid snakes (subfamily Hydrophiinae) based on cytochrome b and 16S rRNA sequences [16].
• From the peak areas of the 3 chains obtained by CM 52 column chromatography, and the peak sizes of the 3 bands separated by SDS gel electrophoresis, it was concluded that the sea snake hemoglobin is composed of a hybrid tetramer, alpha2betabeta' [17].
• A toxic phospholipase A2 (PLA2-H1), isolated from the venom of the sea snake Hydrophis cyanocinctus, was tested for its ability to induce myonecrosis and histopathological changes in albino rats and mice [18].
• In order to investigate the presence or absence of NGF, five sea snake venoms were selected [19].

Analytical, diagnostic and therapeutic context of Hydrophidae

• The effects of sea snake venom (SSV) on renal function were studied in two groups of anesthetized experimental dogs pretreated with intravenous infusion of 4.2 gm% NaHCO3 solution [20].

References