Disease relevance of Asperger Syndrome

• Subsequently neither haloperidol nor a second antipsychotic drug altered the core features of Asperger's syndrome, despite suppressing the movement disorder [1].

Psychiatry related information on Asperger Syndrome

• Patients with autistic disorder and PDD NOS did significantly better than those with Asperger's disorder [2].
• Tests were administered to children with a diagnosis of Autistic Disorder (AutD; n = 20), Asperger's Disorder (AspD; n = 28), Attention Deficit/Hyperactivity Disorder (Inattentive Type) (ADHD; n = 35), Mental Retardation (Mild) (MR; n = 34), Anxiety Disorder (AnxD; n = 14), or No Psychological Disorder (NPD; n = 36) [3].

High impact information on Asperger Syndrome

• Cortical Serotonin 5-HT2A Receptor Binding and Social Communication in Adults With Asperger's Syndrome: An in Vivo SPECT Study [4].
• Open-label risperidone for Asperger's disorder: negative symptom spectrum response [5].
• Eleven adult patients with autism or Asperger's disorder were randomized to single dose sumatriptan (6 mg SQ) and placebo challenges, separated by a one-week interval [6].
• Forty-two adults with PDDs (autistic disorder, N = 22; Asperger's disorder, N = 6; and PDD not otherwise specified [NOS], N = 14) participated in a 12-week, open-label, systematic trial of sertraline [2].
• An eight-year-old boy with Asperger's syndrome was given haloperidol to control agitation and aggressive outbursts [1].

Chemical compound and disease context of Asperger Syndrome

• Increased presynaptic dopamine function in Asperger syndrome [7].
• METHOD: Selective review of the literature detailing data pertaining to symptoms and disorders sometimes encountered in connection with autism or Asperger syndrome [8].
• This study examined the effect of m-chlorophenylpiperazine (m-CPP) on repetitive behaviours and prolactin response in 11 adults with autism or Aspergers disorder and 8 age- and gender-matched healthy controls via randomized double-blind, m-CPP and placebo challenges [9].
• OBJECTIVE: To report a case of aripiprazole-responsive adult Asperger disorder [10].
• The medical charts of 15 children and adolescents (aged 6-16 yr) with Asperger syndrome, autism, or PDD not otherwise specified treated with citalopram were retrospectively reviewed [11].

Anatomical context of Asperger Syndrome

• It is suggested that all three suffer from a Marfan-like disorder of connective tissue and, more speculatively, that this has led to anomalous development of midline brain structures with consequent social handicaps characteristic of Asperger's syndrome [12].

Gene context of Asperger Syndrome

• Rheumatoid arthritis in a patient with Asperger's syndrome and IDDM [13].
• ADHD, Asperger syndrome, and high-functioning autism [14].
• Fahr's disease and Asperger's syndrome in a patient with primary hypoparathyroidism [15].
• Two groups of individuals, one with high-functioning autism and the other with Asperger syndrome were tested using Happé's Strange Stories Test of a more advanced theory of mind (Happé, 1994) [16].
• The assertions of the children with Asperger syndrome were generally not different than those of the children with SLI or normal development except for a higher proportion of assertions involving own internal state [17].

References