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Chemical Compound Review

BUTOPHEN     azanium2-butan-2-yl-4,6- dinitro-phenolate

Synonyms: Selective, Sinox W, Dow selective, AG-G-36661, CTK5B9633, ...
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Disease relevance of Subitex


Psychiatry related information on Subitex

  • CONCLUSIONS: Selective antagonism of 5-HT3 receptors suppresses the gastric component of phase-3 motor activity and simultaneously suppresses plasma motilin peaks [6].
  • Memory and intelligence were assessed with a battery of neuropsychological tests, including the Russell revision of the Wechsler Memory Scale, the Selective Reminding Test, and subtests of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) [7].
  • OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are recommended for treatment of affect lability, impulsivity, and aggression in patients with borderline personality disorder [8].
  • We used the Free and Cued Selective Reminding Test and the Rey Auditory Verbal Learning Test to evaluate two aspects of memory function thought to be sensitive to the effects of aging: learning (acquisition) and delayed recall (forgetting) [9].
  • BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are efficacious in the treatment of a variety of fear or anxiety disorders [10].

High impact information on Subitex


Chemical compound and disease context of Subitex


Biological context of Subitex

  • IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to Trichinella spiralis infection [21].
  • Isotype specificity of FcR can be reversed on nonactivated Mø by immune lymphokines, and IgG2a immune complexes are more effective triggers of the respiratory burst in activated Mø. Selective enhancement of IgG2a FcR by Mø activation could account for efficacy of homologous ab in mediating cytotoxicity in some systems [22].
  • (a) Selective stimulation of azurophil granule secretion by the Na-ionophore Monensin, or nonselective stimulation by FMLP after cytochalasin B pretreatment elicited marked pinocytic activity in parallel with azurophil granule release, whereas FMLP alone, selective for specific granules, elicited little fluid pinocytosis [23].
  • CONCLUSIONS: Selective in vivo and in vitro activation of the contact system in susceptible Lewis rats suggests that this pathway is one determinant of genetic susceptibility to granulomatous enterocolitis and systemic complications [24].
  • Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation [25].

Anatomical context of Subitex


Associations of Subitex with other chemical compounds


Gene context of Subitex


Analytical, diagnostic and therapeutic context of Subitex


  1. Composition of human colonic mucin. Selective alteration in inflammatory bowel disease. Podolsky, D.K., Isselbacher, K.J. J. Clin. Invest. (1983) [Pubmed]
  2. Pathogenesis of Shigella diarrhea. XVI. Selective targetting of Shiga toxin to villus cells of rabbit jejunum explains the effect of the toxin on intestinal electrolyte transport. Kandel, G., Donohue-Rolfe, A., Donowitz, M., Keusch, G.T. J. Clin. Invest. (1989) [Pubmed]
  3. Protective immunity in bancroftian filariasis. Selective recognition of a 43-kD larval stage antigen by infection-free individuals in an endemic area. Freedman, D.O., Nutman, T.B., Ottesen, E.A. J. Clin. Invest. (1989) [Pubmed]
  4. An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis. Cho, J.J., Hocher, B., Herbst, H., Jia, J.D., Ruehl, M., Hahn, E.G., Riecken, E.O., Schuppan, D. Gastroenterology (2000) [Pubmed]
  5. Letter: Selective IgA deficiency. Dalderup, L.M., Freni, S.C., Bras, G., Bronckhorst, F.B. Lancet (1976) [Pubmed]
  6. 5-hydroxytryptamine-3 receptors are involved in the initiation of gastric phase-3 motor activity in humans. Wilmer, A., Tack, J., Coremans, G., Janssens, J., Peeters, T., Vantrappen, G. Gastroenterology (1993) [Pubmed]
  7. Deficits in short-term memory in posttraumatic stress disorder. Bremner, J.D., Scott, T.M., Delaney, R.C., Southwick, S.M., Mason, J.W., Johnson, D.R., Innis, R.B., McCarthy, G., Charney, D.S. The American journal of psychiatry. (1993) [Pubmed]
  8. SSRI treatment of borderline personality disorder: a randomized, placebo-controlled clinical trial for female patients with borderline personality disorder. Rinne, T., van den Brink, W., Wouters, L., van Dyck, R. The American journal of psychiatry. (2002) [Pubmed]
  9. Memory function in normal aging. Petersen, R.C., Smith, G., Kokmen, E., Ivnik, R.J., Tangalos, E.G. Neurology (1992) [Pubmed]
  10. The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine. Burghardt, N.S., Sullivan, G.M., McEwen, B.S., Gorman, J.M., LeDoux, J.E. Biol. Psychiatry (2004) [Pubmed]
  11. Immunological memory. Gray, D. Annu. Rev. Immunol. (1993) [Pubmed]
  12. Selective postoperative inhibition of gastrointestinal opioid receptors. Taguchi, A., Sharma, N., Saleem, R.M., Sessler, D.I., Carpenter, R.L., Seyedsadr, M., Kurz, A. N. Engl. J. Med. (2001) [Pubmed]
  13. A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. The French Study Group on Selective Decontamination of the Digestive Tract. Gastinne, H., Wolff, M., Delatour, F., Faurisson, F., Chevret, S. N. Engl. J. Med. (1992) [Pubmed]
  14. Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation. Bass, H., Mosmann, T., Strober, S. J. Exp. Med. (1989) [Pubmed]
  15. Alloreactive cytolytic T cell clones with dual recognition of HLA-B27 and HLA-DR2 antigens. Selective involvement of CD8 in their class I--directed cytotoxicity. Aparicio, P., Jaraquemada, D., López de Castro, J.A. J. Exp. Med. (1987) [Pubmed]
  16. Correspondence re: Yasuyuki Sugiyama et al., Selective growth inhibition of human lung cancer cell lines bearing a surface glycoprotein gp160 by 125I-labeled anti-gp160 monoclonal antibody. McLaughlin, W.H., Epperly, M.W., Bloomer, W.D. Cancer Res. (1989) [Pubmed]
  17. Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin. Murayama, T., Ui, M. J. Biol. Chem. (1985) [Pubmed]
  18. Characterization of human type I and type II IMP dehydrogenases. Carr, S.F., Papp, E., Wu, J.C., Natsumeda, Y. J. Biol. Chem. (1993) [Pubmed]
  19. Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. Jeyaseelan, R., Poizat, C., Wu, H.Y., Kedes, L. J. Biol. Chem. (1997) [Pubmed]
  20. Microsatellite instability of selective target genes in HNPCC-associated colon adenomas. Woerner, S.M., Kloor, M., Mueller, A., Rueschoff, J., Friedrichs, N., Buettner, R., Buzello, M., Kienle, P., Knaebel, H.P., Kunstmann, E., Pagenstecher, C., Schackert, H.K., Möslein, G., Vogelsang, H., von Knebel Doeberitz, M., Gebert, J.F. Oncogene (2005) [Pubmed]
  21. IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to Trichinella spiralis infection. Dessein, A.J., Parker, W.L., James, S.L., David, J.R. J. Exp. Med. (1981) [Pubmed]
  22. Macrophage activation selectively enhances expression of Fc receptors for IgG2a. Ezekowitz, R.A., Bampton, M., Gordon, S. J. Exp. Med. (1983) [Pubmed]
  23. Linkage of azurophil granule secretion in neutrophils to chloride ion transport and endosomal transcytosis. Fittschen, C., Henson, P.M. J. Clin. Invest. (1994) [Pubmed]
  24. Selective kallikrein-kinin system activation in inbred rats differentially susceptible to granulomatous enterocolitis. Sartor, R.B., DeLa Cadena, R.A., Green, K.D., Stadnicki, A., Davis, S.W., Schwab, J.H., Adam, A.A., Raymond, P., Colman, R.W. Gastroenterology (1996) [Pubmed]
  25. Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. Sánchez, I., Hassinger, L., Sihag, R.K., Cleveland, D.W., Mohan, P., Nixon, R.A. J. Cell Biol. (2000) [Pubmed]
  26. Mutual recognition of parental and F1 lymphocytes. Selective abrogation of cytotoxic potential of F1 lymphocytes by parental lymphocytes. Shearer, G.M., Polisson, R.P. J. Exp. Med. (1980) [Pubmed]
  27. Migratory behavior of lymphocytes with specific reactivity to alloantigens. II. Selective recruitment to lymphoid cell allografts and their draining lymph nodes. Emeson, E.E. J. Exp. Med. (1978) [Pubmed]
  28. Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. II. Selective inactivation of hapten-reactive suppressor T cells by hapten-nonimmunogenic copolymers of D-amino acids, and its application to the study of suppressor T-cell effect on helper T-cell development. Hamaoka, T., Yoshizawa, M., Yamamoto, H., Kuroki, M., Kitagawa, M. J. Exp. Med. (1977) [Pubmed]
  29. Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein. Davitz, M.A., Low, M.G., Nussenzweig, V. J. Exp. Med. (1986) [Pubmed]
  30. Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen. Rickard, D.J., Hofbauer, L.C., Bonde, S.K., Gori, F., Spelsberg, T.C., Riggs, B.L. J. Clin. Invest. (1998) [Pubmed]
  31. Branched chain amino acid oxidation in cultured rat skeletal muscle cells. Selective inhibition by clofibric acid. Pardridge, W.M., Casanello-Ertl, D., Duducgian-Vartavarian, L. J. Clin. Invest. (1980) [Pubmed]
  32. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity. Wallace, J.L., Bak, A., McKnight, W., Asfaha, S., Sharkey, K.A., MacNaughton, W.K. Gastroenterology (1998) [Pubmed]
  33. Early Onset of Selective Serotonin Reuptake Inhibitor Antidepressant Action: Systematic Review and Meta-analysis. Taylor, M.J., Freemantle, N., Geddes, J.R., Bhagwagar, Z. Arch. Gen. Psychiatry (2006) [Pubmed]
  34. How to keep up with the medical literature: III. Expanding the number of journals you read regularly. Haynes, R.B., McKibbon, K.A., Fitzgerald, D., Guyatt, G.H., Walker, C.J., Sackett, D.L. Ann. Intern. Med. (1986) [Pubmed]
  35. Plasma cholesterol regulates soluble cell adhesion molecule expression in familial hypercholesterolemia. Sampietro, T., Tuoni, M., Ferdeghini, M., Ciardi, A., Marraccini, P., Prontera, C., Sassi, G., Taddei, M., Bionda, A. Circulation (1997) [Pubmed]
  36. Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2. De Blasi, A., Parruti, G., Sallese, M. J. Clin. Invest. (1995) [Pubmed]
  37. Endothelin ETA and ETB receptors cause vasoconstriction of human resistance and capacitance vessels in vivo. Haynes, W.G., Strachan, F.E., Webb, D.J. Circulation (1995) [Pubmed]
  38. Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1. McGuire, T.F., Trump, D.L., Johnson, C.S. J. Biol. Chem. (2001) [Pubmed]
  39. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b. Al-Shami, A., Mahanna, W., Naccache, P.H. J. Biol. Chem. (1998) [Pubmed]
  40. Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2. Jones, S.A., Dewald, B., Clark-Lewis, I., Baggiolini, M. J. Biol. Chem. (1997) [Pubmed]
  41. Intravenous pyelography: the case against its routine use. Mushlin, A.I., Thornbury, J.R. Ann. Intern. Med. (1989) [Pubmed]
  42. Selective vagal denervation of the atria eliminates heart rate variability and baroreflex sensitivity while preserving ventricular innervation. Chiou, C.W., Zipes, D.P. Circulation (1998) [Pubmed]
  43. Characterization of atrioventricular nodal behavior and ventricular response during atrial fibrillation before and after a selective slow-pathway ablation. Blanck, Z., Dhala, A.A., Sra, J., Deshpande, S.S., Anderson, A.J., Akhtar, M., Jazayeri, M.R. Circulation (1995) [Pubmed]
  44. Retrospective analysis of selective lymphadenectomy in apparent early-stage endometrial cancer. Cragun, J.M., Havrilesky, L.J., Calingaert, B., Synan, I., Secord, A.A., Soper, J.T., Clarke-Pearson, D.L., Berchuck, A. J. Clin. Oncol. (2005) [Pubmed]
  45. beta-Adrenergic and muscarinic receptors in developing rat parotid glands. Selective effect of neonatal sympathetic denervation. Ludford, J.M., Talamo, B.R. J. Biol. Chem. (1980) [Pubmed]
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