Disease relevance of Sleep-Wake Transition Disorders

• Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in elderly patients with hypertension [1].
• Taking the effectiveness and the safety into consideration, the usefulness was assessed as 86.2%, 57.1%, 53.9% and 72.8% for treating nocturnal leg cramps, cervical spondylosis, thalamic pain and carpal tunnel syndrome, respectively [2].

High impact information on Sleep-Wake Transition Disorders

• OBJECTIVE--This study compared the efficacy and safety of quinine sulfate, vitamin E, and placebo in the treatment of nocturnal leg cramps [3].
• Treatment of nocturnal leg cramps. A crossover trial of quinine vs vitamin E [3].
• CONCLUSIONS--Quinine sulfate, but not vitamin E, is superior to placebo in the treatment of nocturnal leg cramps [3].
• Verapamil vs quinine in recumbent nocturnal leg cramps in the elderly [4].
• CONCLUSIONS: Magnesium was not effective for the treatment of nocturnal leg cramps [5].

Chemical compound and disease context of Sleep-Wake Transition Disorders

• In an open-labeled trial with eight elderly patients (aged 62 to 87 years) suffering from nocturnal leg cramps refractory to treatment with quinine sulfate, we ruled out other active disease processes and substituted verapamil hydrochloride therapy (120 mg at bedtime) [6].
• Treatment with vitamin B complex significantly reduced the frequency, intensity, and duration of nocturnal leg cramps [1].
• Diltiazem for nocturnal leg cramps [7].
• BACKGROUND: Quinine is a common treatment for nocturnal leg cramps but has potential side effects [8].

Biological context of Sleep-Wake Transition Disorders

• A 45-year-old woman with longstanding rheumatoid arthritis experienced wheezing, severe anxiety, breathlessness, cough, orthopnea, mild fever, chills, and pleuritic chest discomfort after taking a single dose of quinine for nocturnal leg cramps [9].

References