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Chemical Compound Review

Falicard     2-(3,4-dimethoxyphenyl)-5-[2- (3,4...

Synonyms: Calaptin, Corpamil, Finoptin, Hormitol, Ikapress, ...
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Disease relevance of VERAPAMIL


Psychiatry related information on VERAPAMIL


High impact information on VERAPAMIL


Chemical compound and disease context of VERAPAMIL


Biological context of VERAPAMIL


Anatomical context of VERAPAMIL

  • To study this issue we examined the [Ca2+]i and ATP content of lipid cells and Vmax of Na(+)-K(+)-ATPase and Ca2+ ATPase of membrane preparation and Na(+)-Ca2+ exchange of membrane vesicles of adipocytes from normal rats, 6 week CRF, CRF normocalcemic parathyroidectomized (CRF-PTX) and CRF, and normal rats treated with verpamil (CRF-V, normal-V) [22].
  • The precise mechanism of action of verapamil hydrochloride remains unclear, but could include effects on T-cell migration and activation, on antigen-presenting cells, and/or on other cells [14].
  • Verapamil hydrochloride is an organic calcium antagonist that is known to decrease the contraction of smooth muscle [23].
  • Orally administered verapamil hydrochloride (80 mg every 8 hours) or a placebo was given to 109 patients after coronary artery bypass grafting in a randomized, double-blind manner to test the efficacy of verapamil in preventing postoperative atrial dysrhythmias [24].
  • Isoptin (alpha-isopropyl-alpha-(N-methyl-N-homoveratryl)-gamma-amino-propyl-3,4-dimethoxyphenylacetonitril-hydrochloride)--a calcium antagonist--inhibits mitogenic stimulation of lymphocytes [25].

Associations of VERAPAMIL with other chemical compounds


Gene context of VERAPAMIL

  • With verapamil SR 480 mg/day, 91% of patients had reductions in SBP and DBP greater than 20 and 15mm Hg, respectively [30].
  • The underlying philosophy combines flexible docking (software Yeti) for the identification of the binding mode(s) and 6D-QSAR (software Quasar) for their quantification [31].
  • Using a 4D-QSAR approach (software Quasar) allowing for multiple-conformation, orientation, and protonation-state ligand representation as well as for the simulation of local induced-fit phenomena, we have validated a family of receptor surrogates for the neurokinin-1 (NK-1) receptor system [32].
  • METHODS AND MATERIALS: The 180 patients with Gleason score 8- 10 adenocarcinoma of the prostrate were treated with 3DCRT at the Univer sity of Michigan Health System, University of California-San Francisco, or Fox Chase Cancer. Eligible patients had T1-T4 NO or NX MO adenocarci noma with a pretreatment PSA [33].
  • The underlying technology (software Quasar and Raptor, respectively) specifically allows for induced fit, solvation phenomena and entropic effects [34].

Analytical, diagnostic and therapeutic context of VERAPAMIL


  1. Verapamil prophylaxis of migraine. A double-blind, placebo-controlled study. Solomon, G.D., Steel, J.G., Spaccavento, L.J. JAMA (1983) [Pubmed]
  2. Clinical and biochemical effects of verapamil administration to schizophrenic patients. Pickar, D., Wolkowitz, O.M., Doran, A.R., Labarca, R., Roy, A., Breier, A., Narang, P.K. Arch. Gen. Psychiatry (1987) [Pubmed]
  3. Oral verapamil inhibits platelet thrombus formation in humans. L-Lacoste, L., Lam, J.Y., Hung, J., Waters, D. Circulation (1994) [Pubmed]
  4. Effects of intracoronary verapamil administration in a sheep model of acute myocardial ischemia and reperfusion. Korn, R.L., Pollock, J.V., Spath, J.A. Circ. Res. (1988) [Pubmed]
  5. Twice-daily administration of oral verapamil in the treatment of essential hypertension. Frishman, W., Charlap, S., Kimmel, B., Saltzberg, S., Stroh, J., Weinberg, P., Monuszko, E., Wiezner, J., Dorsa, F., Pollack, S. Arch. Intern. Med. (1986) [Pubmed]
  6. Comparison of the electrophysiologic effects of oral sustained-release and intravenous verapamil in patients with paroxysmal supraventricular tachycardia. Lai, W.T., Voon, W.C., Yen, H.W., Chang, J.S., Sheu, S.H., Hwang, Y.S., Chiu, H.F. Am. J. Cardiol. (1993) [Pubmed]
  7. Use of isoptin for counteracting the effect of methol on cardiac activity in experimental animals. Domahidi, J., Péter, K., Farkas, J. Acta physiologica Hungarica. (2000) [Pubmed]
  8. Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila. Sahly, I., Bar Nachum, S., Suss-Toby, E., Rom, A., Peretz, A., Kleiman, J., Byk, T., Selinger, Z., Minke, B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  9. Cardiovascular effects of verapamil in patients with essential hypertension. Schmieder, R.E., Messerli, F.H., Garavaglia, G.E., Nunez, B.D. Circulation (1987) [Pubmed]
  10. Medical therapy, symptoms, and the distress the cause: relation to quality of life in patients with angina pectoris and/or hypertension. Hollenberg, N.K., Williams, G.H., Anderson, R. Arch. Intern. Med. (2000) [Pubmed]
  11. Angiotensin-converting enzyme inhibitors, calcium channel blockers, and breast cancer. Meier, C.R., Derby, L.E., Jick, S.S., Jick, H. Arch. Intern. Med. (2000) [Pubmed]
  12. Hypertensive black men and women. Quality of life and effects of antihypertensive medications. Black Hypertension Quality of Life Multicenter Trial Group. Croog, S.H., Kong, B.W., Levine, S., Weir, M.R., Baume, R.M., Saunders, E. Arch. Intern. Med. (1990) [Pubmed]
  13. Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy. Bakris, G.L., Copley, J.B., Vicknair, N., Sadler, R., Leurgans, S. Kidney Int. (1996) [Pubmed]
  14. Topically applied verapamil hydrochloride inhibits tuberculin-induced delayed-type hypersensitivity reactions in human skin. McFadden, J., Bacon, K., Camp, R. J. Invest. Dermatol. (1992) [Pubmed]
  15. Preliminary clinical experience with calcium antagonists in atherosclerosis. Verapamil in Hypertension Atherosclerosis Study Investigators. Magnani, B., Dal Palù, C., Zanchetti, A. Drugs (1992) [Pubmed]
  16. Verapamil SR and trandolapril combination therapy in hypertension--a clinical trial of factorial design. German Hypertension Study Group. Scholze, J., Zilles, P., Compagnone, D. British journal of clinical pharmacology. (1998) [Pubmed]
  17. Ventricular fibrillation following adenosine administration. A case report. Ben-Sorek, E.S., Wiesel, J. Arch. Intern. Med. (1993) [Pubmed]
  18. Double-blind crossover randomized trial of intravenously administered verapamil. Its use for atrial fibrillation and flutter following open heart surgery. Hwang, M.H., Danoviz, J., Pacold, I., Rad, N., Loeb, H.S., Gunnar, R.M. Arch. Intern. Med. (1984) [Pubmed]
  19. Improving control of hypertension by an integrated approach -- results of the 'Manage it well!' programme. Szirmai, L.A., Arnold, C., Farsang, C. J. Hypertens. (2005) [Pubmed]
  20. Bioequivalence of controlled-release calcium antagonists. Schall, R., Müller, F.R., Müller, F.O., Luus, H.G. Clinical pharmacokinetics. (1997) [Pubmed]
  21. Cardiovascular action of verapamil in the dog with particular reference to myocardial contractility and atrioventricular conduction. Angus, J.A., Richmond, D.R., Dhumma-Upakorn, P., Cobbin, L.B., Goodman, A.H. Cardiovasc. Res. (1976) [Pubmed]
  22. Elevated cytosolic calcium of adipocytes in chronic renal failure. Ni, Z., Smogorzewski, M., Massry, S.G. Kidney Int. (1995) [Pubmed]
  23. The effect of verapamil on the lower esophageal sphincter pressure in normal subjects and in achalasia. Becker, B.S., Burakoff, R. Am. J. Gastroenterol. (1983) [Pubmed]
  24. Verapamil prophylaxis for postoperative atrial dysrhythmias: a prospective, randomized, double-blind study using drug level monitoring. Ferraris, V.A., Ferraris, S.P., Gilliam, H., Berry, W. Ann. Thorac. Surg. (1987) [Pubmed]
  25. Inhibition by isoptin (a calcium antagonist) of the mitogenic stimulation of lymphocytes prior to the S-phase. Blitstein-Willinger, E., Diamantstein, T. Immunology (1978) [Pubmed]
  26. Utility of a transdermal delivery system for antihypertensive therapy. Part 1. Sclar, D.A., Skaer, T.L., Chin, A., Okamoto, M.P., Gill, M.A. Am. J. Med. (1991) [Pubmed]
  27. A comparison of the effects of nifedipine and verapamil on exercise performance in patients with mild to moderate hypertension. Halperin, A.K., Icenogle, M.V., Kapsner, C.O., Chick, T.W., Roehnert, J., Murata, G.H. Am. J. Hypertens. (1993) [Pubmed]
  28. Influence of methacrylic and acrylic acid polymers on the release performance of weakly basic drugs from sustained release hydrophilic matrices. Tatavarti, A.S., Mehta, K.A., Augsburger, L.L., Hoag, S.W. Journal of pharmaceutical sciences. (2004) [Pubmed]
  29. A comparison of the antihypertensive effectiveness of a combination of moexipril or sustained-release verapamil with low-dose hydrochlorothiazide. Chrysant, S.G., Stimpel, M. Journal of clinical pharmacology. (1996) [Pubmed]
  30. Comparative efficacy, safety and pharmacokinetics of verapamil SR vs verapamil IR in hypertensive patients. Fuenmayor, N.T., Faggin, B.M., Cubeddu, L.X. Drugs (1992) [Pubmed]
  31. Combining protein modeling and 6D-QSAR. Simulating the binding of structurally diverse ligands to the estrogen receptor. Vedani, A., Dobler, M., Lill, M.A. J. Med. Chem. (2005) [Pubmed]
  32. Multiple-conformation and protonation-state representation in 4D-QSAR: the neurokinin-1 receptor system. Vedani, A., Briem, H., Dobler, M., Dollinger, H., McMasters, D.R. J. Med. Chem. (2000) [Pubmed]
  33. 3D conformal radiation therapy (3DCRT) for high grade prostate cancer: a multi-institutional review. Fiveash, J.B., Hanks, G., Roach, M., Wang, S., Vigneault, E., McLaughlin, P.W., Sandler, H.M. Int. J. Radiat. Oncol. Biol. Phys. (2000) [Pubmed]
  34. In silico prediction of harmful effects triggered by drugs and chemicals. Vedani, A., Dobler, M., Lill, M.A. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  35. Verapamil in prophylactic therapy of migraine. Markley, H.G., Cheronis, J.C., Piepho, R.W. Neurology (1984) [Pubmed]
  36. Drug loading onto ion-exchange microspheres: Modeling study and experimental verification. Abdekhodaie, M.J., Wu, X.Y. Biomaterials (2006) [Pubmed]
  37. Comparison of two calcium blockers on hemodynamics, left ventricular mass, and coronary vasodilatory in advanced hypertension. Diamond, J.A., Krakoff, L.R., Goldman, A., Coplan, N., Gharavi, A., Martin, K., Goldsmith, R., Henzlova, M.J., Machac, J., Phillips, R.A. Am. J. Hypertens. (2001) [Pubmed]
  38. Newborn myocardial protection after prolonged prearrest cooling: a calcium overload phenomenon? Shum-Tim, D., Tchervenkov, C.I., Lough, J.O., Chiu, R.C. Ann. Thorac. Surg. (1994) [Pubmed]
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